Posted by admin on Feb 28, 2023 in |
Nabumetone (NBT), a non-steroidal anti-inflammatory drug used to treat rheumatoid arthritis, is rapidly metabolized in the liver and is well known for its side effects along with its sensitivity to light; thus, it limits the formulation of a such drug when considered for skin formulations. Recently introduced a new type of carrier for bioavailability benefits and patient compliance, the “transfersomes”. Due to its elastic nature, which can deform and squeeze themselves because of their flexibility through narrow pores of stratum corneum, the transfersomes were prepared by use of phospholipid and sodium cholate, tween 80 as edge activators. The NBT loaded transfersomes were optimized by the three factors and two levels Box-Behnken design using Design-Expert software (version 12). Independent formulation variables such as concentrations of a phospholipid, concentration of sodium cholate, and tween 80 were evaluated. The prepared TFs were evaluated with respect to particle size, % entrapment efficiency, and % drug release. The optimized batch F1 was formulated by incorporation into a Carbopol-940 gel base. The prepared NBT-loaded TFs...
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Posted by admin on Feb 28, 2023 in |
Pain is the most common reason for physician consultation. Among the currently available analgesic drugs, opioids are the most efficacious but have many unacceptable adverse effects. Melatonin has been found to have antinociceptive potential in many animal and clinical studies that need further evaluation. The study aimed to assess the antinociceptive effect of melatonin alone and in combination with pethidine. Twenty Swiss albino mice were divided into four groups, each containing five animals receiving respective drugs. Tail flick and tail clip methods were used to assess antinociceptive effect of the drug. The reaction time of each animal in each group was taken at 0 min, 30 min, 60 min, 90 min and 120 min and the experiment was conducted on day 0, day 7, day 14 and day 28. Mean reaction time averaged over day 0, day 7, day 14 and day 28 was used to make inter-group comparisons. The mean reaction time increased in all groups except group I, in both tail flick and tail clip methods suggesting...
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Posted by admin on Feb 28, 2023 in |
Background and Aim: The prevalence of DM worldwide is estimated to be 415 million, which is anticipated to surpass 642 million in the next 25 years. Good glycaemic control reduces the incidence of complications associated with diabetes and thus improves microvascular diseases. Complexity can be regarded as the root cause of low adherence and thus result in interactions. This study aimed to evaluate the complexity of medication regimens in patients diagnosed with diabetes mellitus and its impact on medication adherence and glycaemic control. Methodology: A hospital-based cross-sectional study was conducted on 265 patients with diabetes in NIMS Medicity, Kerala, for 6 months, and the association between predictive and outcome variables was analyzed. Results: The final analysis included 265 diabetic patients who met the inclusion criteria. Around 66.03% of patients showed a high level of patient-specific MRCI, while 3% had high diabetes-specific MRCI. Almost 26.4% of patients showed high compliance with diabetic medications. Most patients included in the study (66%) showed poor glycemic control. The patients with severe patient-specific MRCI...
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Posted by admin on Feb 28, 2023 in |
People throughout the world have long used various fruits, leaves, and plant parts as nutraceuticals and valuable sources of herbal treatments. Apples (Malus domestica) are a popular fruit with a high level of medicinal efficacy, whose seeds have also demonstrated a very high therapeutic and nutritional value when ingested in the right amount and form (apple seed flour or oil). Found in cold temperate regions worldwide and in the states of Jammu and Kashmir, Himachal Pradesh, Uttaranchal, Uttar Pradesh and Arunachal Pradesh in India. Malus domestica fruit, peels and seeds, when extracted in alcohol or acetone medium, show a high content of proteins, fatty acids, dietary fibres, polyphenols, vitamins and minerals, polysaccharides, phytosterols, pentacyclic triterpenes and cyanogenic glycosides (amygdalin). Polyphenols like proanthocyannidin, catechin, quercetin, phloridzin are very effective in treating hyperglycemia, cholesterol, neuropsychiatric diseases, cancer, and gastrointestinal disorders. Another cytotoxic component present in the seeds is amygdalin, which shows anti-proliferative and anti-inflammatory properties. Other than this, pectin, a polysaccharide (peel and seeds), phytosterols (leaves, stem, root, seeds), pentacyclic triterpenes...
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Posted by admin on Feb 28, 2023 in |
A simple, accurate, and precise dual-wavelength spectrophotometric method was developed to determine Paracetamol and Piroxicam in combined pharmaceutical dosage form simultaneously. The principle for the dual wavelength method is “the absorbance difference between two points on the mixture spectra is directly proportional to the concentration of the component of interest”. The pre‐requisite for the dual wavelength method is the selection of two such wavelengths where the interfering component shows the same absorbance. In contrast, the component of interest shows a significant difference in absorbance with concentration. The wavelengths selected for paracetamol were 257nm, whereas the wavelengths selected for the determination of Piroxicam were 353nm. 0.5M NaOH was taken as a solvent. The regression analysis of Beer’s plots showed good correlation in a concentration range of 2‐10 μg/ml for paracetamol and 2‐10 μg/ml for Piroxicam. The accuracy method was found to be between 97.33‐101.5%. The method’s precision (intra‐day, inter‐day, and repeatability) was found within limits. The proposed method was successfully applied to determine these drugs in commercial...
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