Posted by admin on Nov 30, 2024 in |
Background- Depression is a mental health condition with various symptoms including low energy, disrupted sleep, and suicidal ideation. Antidepressants have negative side effects and can cause drug interactions. Curcuma longa, a herbal extract, has shown potential in treating depression due to its antioxidant and anti-inflammatory properties. A study is planned to evaluate its antidepressant activity. Aim and Objective: To study the anti-depressant activity of Curcuma longa rhizome using animal models and to find out its mechanism of action. Materials and Methods: Ethanolic extraction using Soxhlet apparatus, forced swimming test, open field behavior. Results: Curcuma longa rhizome possess antidepressant property. Conclusion: The study investigated the effectiveness of Curcuma longa rhizome in treating depression. Two doses of the ethanol extract were tested in mice, and their behaviour was assessed in various tests. The extract showed antidepressant action by increasing serotonin, norepinephrine and dopamine levels in the brain and antagonizing the GABA receptor. No sleep-promoting compounds were found in the...
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Posted by admin on Nov 30, 2024 in |
Among all the organic compounds, heterocyclic compounds are the most common and varied class. It has been possible to synthesis a considerable number of heterocyclic molecules thus far. Heterocyclic compounds are getting more and more prevalent due to extensive synthetic study and their synthetic utility. In the realm of medical chemistry, these molecules are useful in several ways. Some common uses include dyes, disinfectants, corrosion inhibitors, antioxidants, and copolymer production. An effective strategy for synthesizing recently identified heterocyclic compounds and their moieties always has some distinctive features. The importance of heterocyclic compounds in curative chemistry has been shown through their neoteric advancements. These compounds exhibit biological activities such as anti-convulsant, anti-HIV, antiviral, anti-allergic, anti-cancer, anti-inflammatory, and antifungal properties. This article gives comprehensive information about these heterocyclic...
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Posted by admin on Nov 30, 2024 in |
Artabotrys thomsonii is a medicinal plant used in the African pharmacopoeia for the treatment of various diseases. It was therefore important to assess its potential risk to human and animal health. This study highlights the acute and sub-acute effects of the toxicological profile of A. thomsonii leaves aqueous extract. The extract was prepared using the traditional protocol, then administered orally to Wistar rats at a single dose of 2000mg/kg for acute test, and of 100, 200 and 400mg/kg once a day for 28 days for sub-acute test. In acute toxicity, no behavioral disturbances were observed in treated animals compared with the control. The lethal dose 50 was estimated to be greater than 2000mg/kg and the extract was noted to possess low toxicity. Similarly, no significant changes in body mass, relative organ mass, hematological or biochemical parameters were observed after 28 days of repeated administration of the extract. Furthermore, administration of the extract did not alter motor coordination or develop anxiety in sub-acute treatment. Histological sections revealed that A. thomsonnii...
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Posted by admin on Nov 30, 2024 in |
Black rice is a rice species, Oryza sativa Linne (Gramineae), which is sticky, high in nutrients, and primarily grown in Asia. In recent years, the health benefits of black rice varieties have been reported due to the presence of a bioactive compound, anthocyanin, which has highly potent activity with high macronutrients. The present study aimed to evaluate and quantify the metabolites, focusing on describing the structure of Cyanidin-3-O-glucoside (CY3G) as a biomarker of anthocyanin present in the extract of black rice. Four different black rice varieties black rice extracts of Poireiton (BREP), Kokngangbi (BREK), Amubi (BREA), and Sempak (BRES) were collected, and phytochemical analyses performed using different standard methods. Compared to other black rice varieties, Amubi, BREA has the highest phenolic (63.23±0.76 mg/g GAE), flavonoid (28.09±0.68 mg/g QE), and anthocyanin (17.69±0.45 mg C/g DEW) content. It also exhibited the highest potent antioxidant activity, with IC50 values of 29.1 ± 1.11 mg/ml in the ABTS assay and 98.83 ± 0.61 mg/ml in the DPPH assay. The FTIR spectroscopy analysis result...
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Posted by admin on Nov 30, 2024 in |
Urolithiasis, commonly known as kidney stone disease, is a prevalent and painful condition resulting from the formation of calculi in the urinary system. This review aims to elucidate the antiurolithiatic properties of medicinal plants, focusing on urolithiasis and stone formation mechanisms. The ethnopharmacological approaches to managing kidney stones highlight the historical and cultural significance of using medicinal plants. Focusing on the ethnobotanical practices in Uttarakhand, it provides a comprehensive list of plants traditionally employed for kidney stone treatment. Specific emphasis is given to the medicinal plants of prime importance, detailing their phytochemical properties and therapeutic efficacy. Furthermore, it reviews global studies on kidney stone treatment, emphasizing pharmacological research and clinical evidence supporting the use of these plants. The interrelation between urolithiasis and non-communicable diseases, such as heart disease, is explored to underline the broader health...
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