Posted by admin on Oct 31, 2024 in |
The present research focused to decide the premier dosage of methanol extract of Lepidagathis fasciculata whole plant extract and examining the α-amylase and α-glucosidase inhibitors of diabetic rats utilized to execute stronger command of hyperglycemia allowed for the blood glucose to be lowered in these animals. In streptozotocin-induced rats, the anti-hyperglycemic effects of oral administration of various doses of methanol extract revealed that the highest dose considerably lowered blood glucose levels analyzed to further dosage. Additionally, ethyl acetate and n-butanol fractions showed a better anti hyperglycaemic impact than n-hexane and chloroform fractions, according to the results of the repeated administration of methanol fractions. In addition, the in-vitro studies results demonstrated that the consequences of methanol extract and its fraction onα-amylase and α-glucosidase enzyme exercises could be controlled with low concentrations of ethyl acetate and n-butanol measured to different fractions and Acarbose, which was utilized as a positive control. These results suggested that the presence of polyphenolic active ingredients allowed the mobile coarse extract (methanol) and its vital fractions (ethyl...
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Posted by admin on Oct 31, 2024 in |
Background/Aims: Polypharmacy, the concurrent use of multiple medications by a single patient, is common in modern healthcare to manage multiple comorbidities. While it helps address complex health conditions, it also brings significant challenges, such as increased risks of drug interactions and adverse effects, including the development of enteric ulcerlesions in the gastrointestinal tract. Methods: This research paper examines the complex relationship between polypharmacy and enteric ulcer formation through a comprehensive literature review. It investigates the mechanisms behind enteric ulcer development and the impact of polypharmacy on gastrointestinal physiology. Results: By analyzing the interactions and consequences of multiple medications on gastrointestinal health, this paper provides valuable insights for clinicians. These insights are aimed at optimizing medication regimens to reduce the risk of enteric ulcers and enhance patient outcomes. This paper aims to clarify the paradox of polypharmacy in relation to enteric ulcer formation. It highlights the complex interactions between multiple medications and gastrointestinal health, offering guidance for healthcare professionals. This guidance is essential for balancing the therapeutic benefits of polypharmacy...
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Posted by admin on Oct 31, 2024 in |
Background: Migraine is a common neurological disorder that presents significant challenges in treatment. Effective management is crucial due to debilitating nature of the condition. Aim: This meta-analysis aims to evaluate efficacy of both pharmacological and non-pharmacological interventions in managing migraine symptoms. Methods: The analysis included 13 studies focusing on various interventions for migraine management. Both pharmacological treatments and non-pharmacological approaches were assessed for their effectiveness. The efficacy of these interventions was measured using statistical methods, including weight difference, standardized mean difference (SMD), and mean difference (MD). Funnel plot analyses were conducted to check for publication bias. Results: Pharmacological interventions showed substantial efficacy compared to placebo, with a significant weight difference of 100.0%, a Z-value of 17.58, and a P-value of less than 0.00001. Non-pharmacological interventions also demonstrated significant effectiveness, with a Z-value of 11.62 and a P-value of less than 0.00001. However, there was considerable heterogeneity among the studies, as indicated by the following statistics: for MD, Chi² = 24.65 with 13 degrees of freedom and a P-value of...
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Posted by admin on Oct 31, 2024 in |
Oral Lichen Planus (OLP) is a rare chronic autoimmune mucocutaneous inflammatory disease characterized by painful oral lessions. Immunosuppressive agent Tacrolimus monohydrate is one of the effective therapy options for OLP as it possesses benefits such as greater safety and efficacy at lower doses over currently employed topical corticosteroids. From amongst its topical dosage forms, mucoadhesive oral gels of Tacrolimus monohydrate have advantages such as prolonged residence time, enhancement of absorption and therapeutic efficacy compared to the topical ointments. Considering this, the current work was aimed at formulating oral mucoadhesive gels of Tacrolimus monohydrate using PEG gel bases and mucoadhesive polymers. Firstly, non medicated mucoadhesive gels consisting of PEG gel bases and mucoadhesive polymers were formulated and evaluated for their appearance, feel, viscosity, pH, spreadability, tube extrudability and mucoadhesive strength. The combinations of PEG gel bases having PEG4000+PEG400 in 1:4, PEG 4000+PEG400 in 1:8 and PEG 6000+PEG400 in 1:4 were selected for incorporation of Tacroliimus monohydrate (0.1%) due to their ideal performance in maintaining the requisite gel characteristics at 400C...
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Posted by admin on Oct 31, 2024 in |
There are a variety of treatment options for melanoma, but the high resistance of tumor cells to conventional therapies makes it necessary to develop new anticancer agents that will have decline toxic effects and greater effectiveness, thereby providing an incentive for the development of new treatments that can be used alone or in combination with other drugs. The flavonoids are phenolic phytoconstituents that have been shown to be efficacious in preventing a wide series of cancers, both in-vitro assays and in animal models, including in melanoma cells. Flavonoids, like naringenin, quercetin and apigenin, among others, have gained significant attention in recent years due to the fact that they possess a wide range of properties, including anti-inflammatory, antioxidant, and antiviral properties. However, its anti-carcinogenic effect, which affects the control of cell proliferation and cell-cycle sequence, induction of apoptosis, and suppression of tumor angiogenesis, may be the most significant. Although flavonoids have exhibited promising results both in-vitro as well as in-vivo, there are some concerns regarding their application to biological environments,...
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