Posted by admin on Oct 31, 2024 in |
Objectives: Lovastatin is an antilipidemic medication categorised as a statin, which exhibits limited absorption when taken orally owing to its low solubility and inconsistent dissolution rate. The primary objective of this research was to improve the drug’s solubility and dissolving rate, as well as gain insight into its oral bioavailability. Materials and Methods: A precipitation-ultrasonication process was used to formulate Lovastatin nanosuspensions, with PVP k30, PEG 6000, and Tween 80 serving as stabilisers. The nanosuspensions that were created were analysed to determine their polydispersity index (PDI), particle size, surface shape, zeta potential, and in-vitro release rate. Results: The optimised formulation exhibited a particle size of 185±0.56 nm, a zeta potential of -27.8 mV, and a PDI of 0.042±0.32, indicating excellent stability. The morphological analysis revealed that the particles had nanoscale dimensions. The drug content was determined to be within the range of 73-94%. The in vitro analysis demonstrated a significantly accelerated drug release within a one-hour timeframe. Stability investigations revealed that the optimised formulation P2 exhibited greater stability when...
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Posted by admin on Oct 31, 2024 in |
New Schiff base metal ion complexes are synthesized and characterized by Mass, TGA, DTA, FTIR, UV-Visible, Conductivity, Magnetic properties, SEM, TEM EDX, and Elemental Analysis. The complexes have the general formula [ML2.H2O], where L=3-{(Z)-[(2-aminophenyl) methylidene] amino}-4-chlorobenzoic acid, and M= Mn (II), Co (II), Ni (II), Cu(II), Zn (II), Pt(II), and Pd(II). The Schiff base’s imino, amine, and carboxylic groups form a bond, the bands observed in the FTIR of the complexes. UV-Visible spectra of the complexes show that they are colour except for Zn (II) complexes. The parameters like the Nephelauxetic effect, covalence parameter b1/2, and co-valence (δ%) are calculated. The complexes are covalent. The central metal ions have eight coordination numbers, and the ligand behaves as bidentate. According to SEM TEM, EDX, and elemental analysis of the complexes, the size of prepared nanoparticles is 16-84 nm. The mass spectra of the ligand and complexes match the theoretically estimated values of Schiff bases and complexes. According to TGA and DTA complexes decompose when temperature rises, and two coordinated water...
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Posted by admin on Oct 31, 2024 in |
Background: Epilepsy is a common neurological disorder which results in significant morbidity. Epilepsy accounts for a significant proportion of the world’s disease burden, affecting around 50 million people worldwide. Aims: In this study, evaluate anti-epileptic drug for seizure control in Emergency room and effectiveness of various anti-epileptic drugs in terms of time to Seizure control. To assess the treatment satisfaction measured using the Treatment Satisfaction with Medicines Questionnaire (SATMED-Q). Materials & Methods: A Prospective observational study of 18 months duration carried out in patients presenting with seizure at Emergency department during the study period. The study began after the approval of study protocol by the Institutional Review Board. Statistical analysis was done using Microsoft Excel Office 2019 and rechecked with SPSS (version 25.0). P value <0.05 was considered as statistically significant. Result: Total 121 patients presented with seizure in Emergency, were recruited in the study during study period. About 98 patients completed the study and 23 were lost to follow-up. Out of 121 patients 80 (66%) were males and...
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Posted by admin on Oct 31, 2024 in |
Spinal anaesthesia is most frequently used for transurethral prostatectomy (TURP), because it permits early recognition of TURP syndrome. However, many elderly patients can have coexisting cardiac or pulmonary disease so, it is important to limit the distribution of spinal block in such patients. Aim and Objectives: To evaluate the efficacy and effect of addition of fentanyl 25 μg (0.5 ml) intrathecally to bupivacaine 5mg (0.5%) (1ml) and low dose bupivacaine 7.5mg (0.5%) (1.5 ml) alone for TURP. Methodology: It was a comparative prospective study under which 60 subjects were enrolled and divided into 2 groups of 30 patients each. Group A will receive Low dose bupivacaine 7.5mg (0.5%) (1.5 ml) Group B will receive bupivacaine 5mg (0.5%) (1ml) and fentanyl 25 μg (0.5). Results: Sensory block duration is higher in group B patients while time of onset of sensory block is low in Group B patients (1.18 + 0.31) in compare to Group A (1.59 + 0.34), similar findings were observed for motor block. In Group A complications of...
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Posted by admin on Oct 31, 2024 in |
Urtica dioica L. and Urtica dioica L. angustifolia are commercialized as the same plant under the name stinging nettles (Ortiga) but, to our knowledge, the antibacterial properties of the variety angustifolia are unknown. The antibacterial activity of Urtica dioica L., collected in the State of Mexico, was compared with that of Urtica dioica L. variety angustifolia, acquired in a market in Mexico City. The extracts were obtained by consecutive maceration of leaves in hexane, dichloromethane, methanol, and water for 48 h, dilutions of 5-0.03 mg/mL of each were added to culture plates with 4 x 106 Colony-forming units (CFU)/mL, resazurin, and Müeller-Hinton medium 3X. The cultures were incubated for 22 h/37°C. The bacteria employed were as follows: Salmonella typhimurium, Shigella flexneri, Salmonella typhi, Proteus mirabilis, Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. Each extract was evaluated on three occasions in triplicate. 1% Dimethyl sulfoxide (DMSO) and a solution of Penicillin-Streptomycin were used as negative and positive control, respectively. In terms of Urtica dioica L., the hexanic and dichloromethanic extracts...
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