Posted by admin on Oct 31, 2024 in |
Cosmetics have been in high demand since ancient times until today. Lipsticks are a type of cosmetic used to enhance their appearance and protect the lips. Generally, waxes, oils, emollients, pigments, and varieties of dye or colouring agents are used to prepare lipsticks. Synthetic colours and other ingredients are hazardous to the human skin and body. Substituting synthetic ingredients with natural substances will decrease the side effects of lipsticks. Also, natural ingredients protect lips from cracking and drying out, etc. With this objective, a study was performed to formulate lipsticks using natural colour extracted from leaves of Amaranthus gangeticus L. It is a popular leafy vegetable in north-east India, and it possesses different pharmacological activities. The phytochemical screening of the extract showed the presence of alkaloids, glycosides, and tannins, which increase the nutritional value of the herb. A total of six formulations were prepared with different concentrations of colour extract and evaluated with parameters such as melting point, breaking point, spreadability, surface anomalies, stability, irritation test, etc. The formulations...
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Posted by admin on Oct 31, 2024 in |
Aim: The aim of the present study was to compare the efficacy of two different doses of labetalol for controlling these hemodynamic responses to laryngoscopy and tracheal intubation in controlled hypertensive patients. Material and Methods: Present study conducted on 90 patients posted for various elective surgeries under general anesthesia at our institute. Study populations were randomly divided into 3 groups. Group L1: Received Inj Labetalol 0.15 mg/kg iv 5 min before intubation, Group L2: Received Inj. Labetalol 0.3 mg/kg iv 5 min before intubation and Group C: Received 0.9% normal saline iv 5 min before intubation. Heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded prior to induction, at time of intubation and various intervals after intubation. Results: The control in HR, SBP, DBP, MAP and RPP was statistically significant between Group L1 and Group L2 at 3 min, 5 min post intubation. There was significant difference in HR throughout study time between L1 C and L2 C. Conclusion: Labetalol in both doses is...
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Posted by admin on Oct 31, 2024 in |
Recently, there has been increasing interest in donkey’s milk. Donkeys’ milk is a good alternative source for infant nutrition in the case of cow milk protein allergy and substitute to human milk. The main aim of this study was to evaluate and compare the proximate composition and physico-chemical properties of Andalusian breed donkey milk with different species mainly buffalo, cow and goat milk obtained from Kamareddy district of Telangana state. The milk samples were analyzed for proximate composition like fat, protein, carbohydrate, ash and total solids, physico-chemical properties such as pH, specific gravity, titratable acidity and viscosity. It was observed from the results that among all the species buffalo and goat milk showed higher levels of all the constituents than that of cow and donkey milk. The specific gravity, titratable acidity, ash, and protein content of buffalo milk showed higher than donkey milk, but had a lower lactose level than donkey, goat and cow milk. All the tested parameters were similar in buffalo and goat milk except lactose which...
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Posted by admin on Oct 31, 2024 in |
This review paper compares medical device regulations across the United States (US), Canada, Europe, India, and Japan. It offers an understanding of the many regulatory frameworks that control the approval processes for medical devices, the Competent Authorities, the rules and regulations, the licensing or registration processes, the classification systems for devices, and the quality management/GMP standards. The US adheres to rigorous approval procedures, encompassing quality system regulations and stringent reporting standards. Health Canada’s regulatory system entails pre-market scrutiny, post-market surveillance, and compliance measures. India’s regulatory landscape requires urgent enhancements to streamline guidelines and implementation strategies. In the European Union (EU), products must meet essential conditions to obtain CE marking for market entry. Japan employs the PMDA & MHLW for safety reviews, approvals, and post-market monitoring. This comparative study underscores the importance of harmonizing global regulatory standards and highlights areas for future improvement. This study outlines key findings and implications, serving as a valuable resource for stakeholders navigating international medical device...
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Posted by admin on Oct 31, 2024 in |
Hepatocellular carcinoma (HCC) is a widespread and lethal cancer type that affects people worldwide. Growth factor signalling pathways are critical in non-alcoholic fatty acid liver disease (NAFLD) and HCC as they activate a cascade of events that disrupt normal liver function. Therefore, these pathways offer a promising therapeutic strategy for NAFLD associated HCC. Several studies have found that fibroblast growth factor (FGF) levels are increased in patients with HCC. The FGF family comprises 22 proteins that can be classified as paracrine, intracrine, or endocrine factors. Most FGFs transmit signals through transmembrane tyrosine kinase FGF receptors. The main FGF in HCC progression includes: FGF8, FGF19 and FGF21, holds potential for HCC treatment. The FGF inhibitors: Lenvatinib, H3B-6527, BLU9931, CXF-009 and FGF401 have shown promising effects, yet our knowledge against HCC is limited. This review summarizes recent research in types of FGF, FGF signalling and FGF inhibitors as therapeutic targets in HCC....
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