Posted by admin on Sep 30, 2024 in |
Aim: The aim of present work is to analytical estimation and process validation of conventional tablet dosage form of Meloxicam. Materials and Methods: Tablets were prepared by wet granulation method. Then coating is done as film coating. Results and Discussion: Melting point, pH of drug was measured in triplicate and mean was notedi.e.253°C, 3.9. The maximum absorption was found to be 350 nm by UV. Various tests like Angle of repose, Bulk density, tapped density, Carr’s Index and Hausner’s ratio are performed at blend stage. Dissolution test and assay is performed of all the three batches. A kinetics study is performed for all the three batches and the result was found satisfactory. Conclusion: Results of the performed tests are to be assessed & summarized to confirm that the procedures followed consistently meet its pre-determined specifications and quality attributes. No maximum variation is found in results. So, our product is...
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Posted by admin on Sep 30, 2024 in |
All three versatile heterocyclic compounds (PCB) are majorly contributing to the field of medicine due to their unique medicinal activities like antimicrobial, anti-inflammatory, anticancer, antioxidant, analgesic, anti-diabetic, anti-viral, anti-ulcer, anti-HIV, and as an anti-protozoal agent (Fig. 1). Many novel PCB analogs are already being used commercially as medicines. Further, the structure-activity relationship and the recent medicinal significance of all three (pyrimidine, coumarin, and benzimidazole) derivatives were discussed. Finally, this comprehensive update may attract synthetic chemists and biologists for further design and development of a novel...
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Posted by admin on Sep 30, 2024 in |
The study was aimed at development of voglibose mouth dissolving tablets which can disintegrate or dissolve rapidly once place in the oral cavity. Voglibose is alpha glycosidase inhibitor, drug which is used in a treatment of type 2 diabetes mellitus. The tablets were prepared with different super disintegrant like crospovidone, sodium starch glycolate and lactose at different concentrations. The blend was evaluated for angle of repose, bulk density, tapped density, carr’s index, Hausner’s ratio and IR studies. The tablets were evaluated for hardness, friability, weight variation, content uniformity test, disintegration test, wetting time. The most satisfactory formulation F6 showed minimum disintegration time of 31 sec and release maximum amount of drug in shortest duration of time in 10 min. it was found to be stable during short term stability studies. Compatibility studies confirmed the absence of any interaction between Voglibose and the selected excipients. The optimized formulation exhibited excellent disintegration time and dissolution profile, meeting the pharmacopoeia requirements for MDTs. Furthermore, sensory evaluation revealed improved palatability compared to conventional...
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Posted by admin on Sep 30, 2024 in |
The local tribes have used Phyllanthus virgatus for Malnutrition, Contagious infections, Inflammations (Gond Tribe), Hepatitis, Cold, Stomach-ache, Gonorrhoea, Fever, Headache, and septic ailments (Chenchus and Yanadis), etc. The gold nanoparticles have a highly specific surface area, and their unique physiochemical characteristics include catalytic activities, optimal properties, antimicrobial activity, etc. Aqueous leaf extract of Phyllanthus virgatus is used to synthesize gold Nanoparticles. The confirmation of biosynthesis of gold nanoparticles was characterized using UV Spectrophotometer, with the maximum scale observed at 551nm. SEM and EDX characterized the morphology of Gold Nanoparticles used to detect the presence of the element gold. The synthesized Nanoparticles were observed to be roughly spherical with a range of 2-50 µm. The dynamic light technique measured the hydrodynamic diameter (28.7nm) and a Zeta potential (-18.6mV). The FTIR analogue shows that the functional group assigned as=C-H, C-C, O-H, –C=C- and –C=O capping agents. The synthesized nanoparticles have shown strong inhibitory action against pathogenic microbial Strains using the Disc diffusion method. Bacillus cereus exhibited more significant results than other...
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Posted by admin on Sep 30, 2024 in |
Look-alike ampoules of tranexamic acid and local anaesthetic heavy bupivacaine are available, leading to accidental administration. We aimed to investigate India-specific incidents of intrathecal tranexamic acid (TXA) administration during spinal anaesthesia to identify manufacturing issues. Our secondary aim was to determine the availability of any national drug error reporting and monitoring system for hospitals in India. The author investigated published ten reports (11 patients) from India of TXA administration intrathecally in place of heavy bupivacaine. In all mistakes of look-like TXA and local anaesthetic (LA) (heavy 0.5% bupivacaine), ampoules were present in operating rooms. We found three manufacturers who designed, manufactured, and supplied identical TXA and heavy bupivacaine ampules. In addition, there was also a similarity of TXA and LA ampoules among different manufacturers. We searched PubMed and Google Scholar for any publication on India’s national medication error reporting system for hospitals. There was no publication on the national medication safety system involving hospitals. Our study shows intrathecal TXA errors occurred in east-to-west and north-to-south locations. However, there is...
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