Posted by admin on Sep 30, 2024 in |
In this comprehensive review, the medicinal properties of Tulsi are thoroughly explored, highlighting its esteemed therapeutic uses that are widely regarded as safe, cost-effective and efficacious owing to its abundant availability. Tulsi a member of the genus Ocimum and a revered medicinal plant native to India has garnered significant recognition and reverence for its profound healing capabilities across generations. Its roots, leaves, and seeds boast a diverse array of medicinal properties, offering a broad spectrum of benefits to human health. Renowned for its anti-aging, immunomodulatory, antimicrobial, and anticancer properties, Tulsi has earned the esteemed title of the ‘Queen of Herbs’ in India symbolizing its paramount importance in traditional Ayurvedic and Unani medicinal practices. Characterized by its distinct square stem and aromatic essence, Tulsi holds a prominent place in Ayurvedic medicine with its extracts frequently utilized in remedies for ailments ranging from common colds and headaches to gastrointestinal disorders, cardiovascular ailments, poisoning, and even...
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Posted by admin on Sep 30, 2024 in |
Drug-delivery systems designed for specific targets allow drugs to be precisely delivered to areas affected by diseases. Various carriers are used to deliver drugs, including immunoglobulins, serum proteins, synthetic polymers, liposomes, niosomes and microspheres. In the last decade, there has been a considerable amount of interest directed towards the advancement of surfactant-based vesicles (known as Niosomes) for the purpose of improving drug delivery. Niosomes are self-assembled vesicular nanocarriers that are produced when cholesterol, non-ionic surfactant, or other amphiphilic compounds are hydrated & having a range of applications, including brain-targeted delivery and cutaneous delivery. Similarly to liposomes, niosomes can carry lipophilic and hydrophilic cargoes due to their bilayer structure. A vast number of research articles have been published on their manufacturing methods and applications in pharmaceuticals and cosmetics. Furthermore, niosomes may be created using simple procedures, need lower production costs, and are viable for extended periods of time, thus eliminating the fundamental limitations of liposomes. This review provides an overview of the present status of niosomal research, including the development...
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Posted by admin on Sep 30, 2024 in |
The review paper comprehensively explores the immunomodulatory potential of Bauhinia variegata flower extract, a traditional medicinal plant renowned for its therapeutic properties. With a focus on its rich history in traditional medicine systems and its diverse pharmacological activities, the paper delves into the botanical and chemical composition of the extract, highlighting key bioactive compounds such as flavonoids, alkaloids, tannins, and phenolic compounds. It meticulously outlines the morphological characteristics of Bauhinia variegata flowers and its traditional medicinal uses, shedding light on its significant role in treating various health ailments. Moreover, the paper meticulously examines the intricate mechanisms underlying the extract’s immunomodulatory effects, including modulation of cytokines, activation of immune cells, antioxidant activity, and regulation of immune signaling pathways. Through in-vitro, in-vivo, and ex-vivo studies, the extract’s ability to enhance immune responses, alleviate inflammation, and mitigate immune-related disorders is thoroughly elucidated. Furthermore, the review offers a glimpse into future perspectives, advocating for continued research to identify specific bioactive compounds, elucidate underlying mechanisms of action, explore synergistic interactions with other drugs, and...
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Posted by admin on Sep 30, 2024 in |
Background: Neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteraemia in the first month of life. Any newborn with bacterial sepsis is at risk of meningitis, but late onset sepsis(LOS) has been fairly associated with meningitis from 3% to 30%.Most common organisms causing neonatal meningitis in developing countries are Gram negative bacteria (GNB) like Klebsiella pneumoniae and Escherichia coli. Objective: To detect microbiological profile of CSF and blood culture and its Antibiotic sensitivity test (AST) in LOS. Methodology: All the Positive sepsis screen patients with clinical suspicion of LOS, CSF and Blood sample were taken for culture and AST and CSF analysis. Result: During the study period 150 neonates 49 (32.6%) were diagnosed with meningitis. 42 were positive for Gram staining of CSF. From 42, CSF culture was positive in 38(25.33%) Neonatal meningitis were more common in male (61.2%) in preterm (73.4%) and in low birth weight (<2500gms) babies (87.7%). 61(40.66%) shows blood culture positive. Klebsiella pneumoniae was the predominant...
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Posted by admin on Sep 30, 2024 in |
Thrombocytosis is defined as platelet count greater than 400, 000/mm3. Thrombocytosis can be either primary or secondary. Meropenem is a parenteral carbapenem antibiotic that has great bactericidal activity against almost all significant aerobes and anaerobes. Common adverse effects such as pain at the injection site, skin rash, transitory metabolic disorders such as increased liver enzyme levels, increased creatinine blood levels, or increased urea levels, or hematological disorders (thrombocytosis, eosinophilia) may be observed. Thrombocytosis due to Meropenem is relatively rare and here we report one such case of Meropenem induced thrombocytosis in a 26-year-old patient post cesarean delivery. A 26-year-old primigravida with 38 weeks gestation presented in labour for four hours. Her investigations revealed hemoglobin of 10.3, deranged LFT and thrombocytopenia. A provisional diagnosis of primigravida with 38 weeks gestation with Fetal Growth Restrictionwith jaundice, thrombocytopenia (TTP) in latent phase of labour was made. Later, the patient was taken up for emergency caesarean in view of fetal distress. Postoperatively the patient was given injectable ceftriaxone and metronidazole. Patient developed high grade fever (101 -103 F) on day 4 for...
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