Posted by admin on Aug 31, 2024 in |
In the pharmaceutical industry, combinatorial chemistry has emerged as a novel approach, facilitating the synthesis of multiple compounds simultaneously rather than focusing on individual compound. The quick production of the chemical means that this technology reduces the time and expense involved in drug research. In this review article, the topic of combinatorial chemistry is discussed in general terms, along with the concepts of combinatorial libraries, methodologies and applications. This technique significantly lowering the cost involved in new drug research and increases the chances of finding new lead molecules. Most commonly used combinatorial techniques are solid phase synthesis, Parallel synthesis, mixed combinatorial synthesis and solution phase synthesis. Combinatorial chemistry is useful for the efficient detection of big molecules as well as the production of tiny molecules and peptides. The aim of this project is to give a fundamental overview of combinatorial chemistry, outlining the evolution of key methods and a few...
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Posted by admin on Aug 31, 2024 in |
Medicinal plants are important for pharmacological research and drug development. Aim and Objective: The aim and objectives of present study was to evaluate the wound healing activity of seed oil of Azadirachta indica in Excision and Incision wound models in rats. Result Discussion: The study thus demonstrated the wound healing activity of Neem seed oil and found to be effective in the functional recovery of the wound. It promotes wound contraction of excision wound as compared to control...
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Posted by admin on Aug 31, 2024 in |
A non-nucleoside reverse transcriptase inhibitor (NNRTI) is Nevirapine. Zidovudine and Lamivudine are antiretroviral medications that are members of the nucleoside analogue class. Combination of three drugs commonly used in the management of the Human Immunodeficiency Virus (HIV) infection. Nevirapine exhibits a decent initial release, while Zidovudine and Lamivudine demonstrate sustained release in the produced trilayer and bilayer tablets. The outcome demonstrates that the release profile is not affected by layer separation and is highly dependent on the drug to polymer ratio. The results show that the release can be effectively controlled for up to 12 hours using a 1:1 ratio of zidovudine and HPMC and a 1:1 ratio of lamivudine and ethyl cellulose. It is clear that formulation F1, out of all formulations, has the best sustained release, drug content, and highest regression values. Nevirapine fits best in first order release of Zidovudine in all of the F1–F6...
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Posted by admin on Aug 31, 2024 in |
“Similia Similibus Curentur,” is the therapeutic law of nature on which Homoeopathy is based. This means “Let like be treated by likes,” with a holistic and dynamic concept. As mentioned in aphorisms no. 6 and 7 (Organon of Medicine, 6th edition of Master Hahnemann) for selection the similimum, the homoeopathic physician forms a portrait of the patient after taking the history and framing “Totality of the Symptoms” with an organized placement of all the subjective and objective symptoms. The prevalence of Osteoarthritis in India is 22% to 39%. It’s a second most common Rheumatological problem facing by population with frequent joint pain, limitation in joint movement which disturbs day to day life. It was estimated as 10 th leading cause of non-fatal burden. Osteoarthritis of knee joint cause mobility impairments commonly found in aged and obese female. After Diabetes and Hypertension Osteoarthritis of the knee is a very common disease these days. Homoeopathic medicines have minute materialistic drug substance in to the potentised form and so it’s safe, and...
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Posted by admin on Aug 31, 2024 in |
The role of rhizospheric symbiotic Arbuscular Mycorrhizal (AM) fungus, non-AM fungus and bacteria in biochemical metabolites production of E. latifolia L. seedlings was analysed. The seedlings were inoculated with AM fungal strain (Glomus species), non-AM fungus (Trichoderma harzianum, Th-13) and bacteria (Pseudomonas species, Ps-1) in combined form (both, dual and triple/tripartite consortium) and analysed for their effect on the total bioactive chemical metabolites production of the target plant species. Qualitative estimation of the secondary metabolites in the said species was done and the following compounds were present viz. alkaloids, tannins, flavonoids, lignin etc. Quantitative estimation of phenolics, flavonoids, anti radical scavenging activity were observed using DPPH assay. The plant carbon and Phosphorus content were also analysed. The maximum phenolic content was obtained in the ethanolic extracts of T3 (173±0.025 mg/g) treated seedlings and the maximum flavonoid content was obtained in the ethanolic extracts of T8 (85.42±0.015 mg/g). Analyses of the free radical scavenging activity revealed that, the highest % inhibition activity was showed by T4 treatment (95.58±0.02) and the...
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