Posted by admin on Aug 31, 2024 in |
An overview of the drug discovery and development process in brief helps scientists whose work could be important in deciding the process to properly design their research report for the successful translation of preclinical research to human subjects. The idea for the drug’s discovery and development may have come from a variety of sources, including the demands of the market at the time, clinical and scholarly research, the commercial environment, etc. In order to control the marketing of drugs, each pharmaceutical industry is required to abide by the laws, rules, and regulations of their respective nation. The majority of newly developed medications on the market today are synthetic. The process of developing new medications is expensive due to the significant expenses linked to research and development as well as clinical trials. Information regarding drugs, the development process, and regulating bodies in Europe, Japan, the USA, and India are provided in this...
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Posted by admin on Aug 31, 2024 in |
The Nigella sativa seeds were collected from Cuddalore and powdered thoroughly by using mortor and pestle. The Nigella sativa seeds were individually extracted with different solvents such as ethanol, methanol, acetone and water. The antibacterial activity of seed extracts were tested against the 6 ATCC pathogens such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Clostridium sporogenes, Bacillus spizizenii and Pseudomonas aeruginosa using Muller Hinton agar. The ethanol extract of Nigella sativa seed showed maximum activity against Klebsiella pneumoniae (12 mm) and Bacillus spizizenii (12 mm). The methanol extract of Nigella sativa seed exhibited minimum activity against Clostridium sporogenes (8mm), Escherichia coli (8mm), Pseudomonas aeruginosa (8mm) and highest activity against Klebsiella pneumoniae (20mm). The acetone extract of Nigella sativa seed showed highest activity against Escherichia coli (20mm). The aqueous extract of Nigella sativa seed showed maximum inhibitory activity against Klebsiella pneumoniae (23mm). Among the 4 solvent extracts, water extracts of Nigella sativa seed showed maximum inhibition. The GC-MS analysis of the Nigella sativa seed extract was carried out and it...
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Posted by admin on Aug 31, 2024 in |
Cigarette smoking and excessive chronic alcohol consumption are accepted risk factors for the causation of various diseases and disorders. Globally 2.5 billion alcoholics and 2.0 billion smokers exist (WHO, 2018). The comorbidity of alcohol and cigarette smoking is highly prevalent. This study is designed to investigate the influence of green tea an effective therapeutic agent to treat the damage caused by the co-use of cigarette smoking and alcohol in humans. Green tea, a water infusion prepared from the dried leaves of Camellia sinensis, is one of the most popular beverages in the world. The major tea catechins are Epigallocatechin-3-gallate (EGCG), Epicatechin (EC), Epicatechin gallate (ECG), Epigallocatechin (EGC). This study had a participation of 150 healthy adult male volunteers between 35 to 65 years of age and weighing between 70 to 85 kg. In this study, EGCG catechin metabolites were detected in the plasma and urine of human volunteers after supplementation of green tea. The served green tea showed the concentrations of various catechins especially EGCG (81.24%), ECG (1.13%), EGC...
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Posted by admin on Aug 31, 2024 in |
Hyperlipidemia is a systemic disease, which is characterized by elevated lipid levels in blood including total cholesterol (TC), total glyceride (TG), low density lipoprotein cholesterol (LDL-c) and so on. It is one of the major risk factors leading to fatty liver, cardiovascular diseases and atherosclerosis and become the first killer of human health. The present study involves synthesis of some novel heterocycles of benzoxazole derivatives containing Oxadiazole and amino triazole and its evaluation of in-vivo and in-silico molecular docking for determining antihyperlipidemic activity. The chemical structures of newly synthesized compounds were evaluated by spectrum of IR, 1HNMR, and LC-MS. The molecular docking studies for the synthesized compounds with PCSK9 showed energy levels ranging from -8 to -10kcal/mol. The compound VD1which shows least binding energy taken for in-vivo antihyperlipidemic activity study. The antihyperlipidemic activity was evaluated by high fat diet induced hyperlipidaemia model and the compound VD1 showed significant reduction in serum lipid parameters as that of standard drug...
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Posted by admin on Aug 31, 2024 in |
Dineśavallīor Vēṁpātais a very popular Ᾱyurvēda herb used in South India for skin related ailments. In Kerala it is used in different formulations either as single drug or in combinations. There are no direct references to dineśavallī or Vēṁpāta in any bŗhatrayī or laghutrayī. From the previous studies it is confirmed that dineśavalli of south India is equated with ‘Ratanjot’– a herbal dye of North India and from the literature review, roots of Arnebia and Alkanna which is sold as ‘Ratanjot’. Dineshavalli (Vēṁpāta) is assumed to be sourced from Ventilago madraspatana Gaertn. belonging to Rhamnaceae family. But some allied species such as Ventilago bombaiensis Dalzell. and Ventilago denticulata Willd. are also termed as Vēṁpāta locally. Present study reviews the major classical texts of Ayurveda and peer reviewed articles to reveal the botanical identity, chemical constituents, pharmacological properties and its therapeutic efficacy of Dineśavallī or Vēṁpāta for the better...
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