Posted by admin on Aug 31, 2024 in |
Metabolic syndrome is the most widely and prevailing health concern globally. It is a cluster of biochemical and physiological abnormalities that involve obesity, insulin resistance, dyslipidemia, and hypertension. Several studies have reported that the prevalence of the overall metabolic syndrome rate in adults is about 25% (approx. 31% in women and 18.5% in men) in India. Whereas the global prevalence is about 20-25% in 2020. The direct relationship between diet and health leads to various scientific studies to find the significant relation and their specific beneficial functions. Certain foods are thought to have physiological effects in the management of metabolic syndrome by assisting the body’s hemostasis mechanism. The present paper reviews different features of nutraceuticals and functional foods and their influence on the management of metabolic syndrome. Also, it overviews numerous functional ingredients in different food sources and their possible health...
Read More
Posted by admin on Aug 31, 2024 in |
Osteoarthritis in the hip creates a major cause of pain and functional limitation. Acupuncture is an effective treatment for reducing inflammation and protecting muscles and produce pain control associated with disorder. Acupuncture is a proven, comprehensive method that helps to restore normal body function. The aim of this study is to find out the effect of acupuncture for relieving chronic hip pain. Here we report a 45-year-old female presenting with swelling, redness and pain on the right hip and with left hip congenital dislocation and eventually diagnosed as right hip osteoarthritis. X-ray showed superior congenital dislocation of left hip. The patient was treated with the selected acupoints ST44, ST36, UB 32, UB 35, UB 40, GB 32, LI4, LI11, DU20, P6, UB60, UB11, and GB34 for half an hour in alternate day for one week and then 15 days once followed for 6 months. VAS was used to measure pain. After treatment, the patient showed improvement in pain and functional ability. The patient is under regular check...
Read More
Posted by admin on Aug 31, 2024 in |
The primary cause of death for women with gynaecological cancer diagnoses is ovarian cancer. It is also, generally speaking, the sixth most common cause of death for women. The majority of cases had advanced diagnoses, which worsens the disease’s prognosis. The limited predictive value of the current screening tests adds even more suffering to the situation. The most important early detection techniques, which have not had a discernible positive impact on the morbidity or death of this malignancy, are comprehensive gynaecological evaluation, transvaginal ultrasonography, and laboratory markers such as the cancer antigen-125 (CA-125) assay. However, anti-angiogenic bevacizumab and Poly (ADP-ribose) polymerase (PARP) inhibitors have gained pace in the management of this condition. Traditionally, the treatment regimen involves surgery and platinum-based chemotherapy. Although the exact etiology of ovarian cancer is unknown, there are several factors that have been found to raise the risk of the illness. Experts understand that DNA alterations, or mutations, occur in ovarian cancer-causing cells when they originate within or close to the ovaries. The instructions that...
Read More
Posted by admin on Aug 31, 2024 in |
Cytochrome P450 2D6 (CYP2D6) is an essential enzyme that affects the safety and effectiveness of a broad range of medications through its metabolism. We provide here an extensive in-silico investigation of new drug candidates that target CYP2D6. To find putative CYP2D6 inhibitors, we used virtual screening, structure-based drug design, molecular docking, and simulation approaches in the Biovia Discovery Studio 2022 framework. By maintaining ADMET and TOPKAT filters, a broad variety of small molecules were subjected to virtual screening. After that, the two chosen compounds, cmp1 and cmp13, were used in molecular docking studies against the 4WNU and 4XRZ proteins to evaluate binding affinities and interactions. For 2815 compounds, ADMET and TOPKAT profiling were done to get non-toxic molecules. The non-toxic molecules after filtrations were taken for the docking studies followed by molecular dynamic simulation of the best complex. The best two molecules after ADMET and TOPKAT profiling were taken for docking studies, where these results demonstrated several intriguing therapeutic options with high binding affinities and favorable interactions of compound cmp1...
Read More
Posted by admin on Aug 31, 2024 in |
Oyster mushrooms are considered functional foods due to their structure. Our work focused on assessing the antioxidant power and determining the secondary metabolite content of mushroom teas formulated from the best-known, cultivated and eaten species. We carried out an ethnonutritional survey, and the species selected were used for the rest. We implemented a mixing plan after which 13 formulations were selected to prepare the various herbal teas. Pleurotus pulmonarius, Pleurotus ostreatus and Pleurotus floridanus were the most cultivated, known, and consumed species. DPPH test revealed that T5, T6 and T2 exhibited the best CI50: 17.39 ± 0.35b, 17.65 ± 1.20b, and 18.93 ± 0.31bc respectively compared to the standard which had a CI50 of: 3.09 ± 1.56a. In the FRAP test, T3, T9 and T11 displayed the best IC50 values: 7.72 ± 2.51b, 10.16 ± 0.14c, 11.00 ± 0.17cd, respectively, while the standard had an IC50 of 1.80 ± 1.06a. In the hydrogen peroxide test, T1, T3 and T4 had the best CI50 values: 23.44 ± 2.94b, 24.98 ±...
Read More
