Posted by admin on Jul 31, 2024 in |
Objectives: Valvular Heart Disease (VHD) is an important cause of cardiovascular morbidity and mortality worldwide. The aim of this study was to establish the frequency of VHD on the basis of echocardiographic parameters, assess etiological factors, quantify the clinical spectrum and evaluate the medical management of VHD. Methods: This observational cross-sectional study was conducted for a period of 5 months from May to September 2021 at a tertiary care hospital in Tamil Nadu. A total of 101 patients, both in-patients and out-patients visiting the cardiology department were included for the study. Results: Among the 101 participants, the mean age was 55.43 ± 14.91 with 55.4% of them being males. The most common etiology was found to be degenerative (75.2%). The most commonly encountered valve lesions included mitral regurgitation (67.3%) followed by aortic regurgitation (36.6%), tricuspid regurgitation (33.7%) and mitral stenosis (21.8%). The prevalence of VHD and VHD of degenerative etiology increased with age >40. The occurrence of VHD symptoms was also higher with age >40 (P<0.001). Conclusion: The major...
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Posted by admin on Jul 31, 2024 in |
“Costus igneus,” popularly known as the “insulin plant,” is a herb that has been used for medicinal purposes in Southeast Asia since ancient times. It is just recently that the plant was imported to India, and in the southern region of the country, it is being grown as an appealing plant. In addition to other phytochemicals, the insulin plant contains elements such as steroids, alkaloids, flavonoids, triterpenes, glycosides, and saponins. Diabetes mellitus is being treated using the leaves of this plant by incorporating them into the diet of the patient. “A leaf a day keeps diabetes away” is the mantra that the plant has adopted. A wide variety of pharmacological effects can be observed, including those that are anti-inflammatory, anti-proliferative, antibacterial, anti-urolithiasis, and anti-diabetic, amongst others. Therefore, the purpose of this review study is to evaluate the many medicinal characteristics of the “insulin plant,” also known as Costus igneus, to make it possible for it to be utilized in future research and to assist...
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Posted by admin on Jul 31, 2024 in |
Fresh Aloe vera plant leaves were brought from botanical garden and sample was identified and brought to the laboratory in the Department of Zoology, Patkar-Varde College, Goregaon (W), Mumbai. 50 grams of leaves were then grounded with 50ml of distilled water in sterilized pestle and mortar. The yield will be calculated based on weight of the extract compared to the weight of the pulp of the leaves. Forty-eight (48) Sprague- dawley rats (average weight 150 – 250 g) of either sex were used for the experiment. The ETH and PAS drug and Aloe vera juice were given to respective groups daily for 28 days. At the end of the study animals were anesthetized and were sacrificed by cervical decapitation. Blood was collected via cardiac puncture and studied for WBC: White blood cell count, LYM: Lymphocytes, MID: Indicates the combined value of the other types of white blood cells not classified as lymphocytes or granulocytes, NEUT: Neutrophils, RBC: Red blood cell count, HGB: Hemoglobin, HCT: Hematocrit and PLT: The platelet counts...
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Posted by admin on Jul 31, 2024 in |
A Liquid Chromatography-Mass Spectrometry (LC-MS/MS) method was used for quantification of potential genotoxic impurities (PGI) in the Darunavir propylene glycolate drug substance (API). Chromatographic separation was achieved using a column UPLC BEH C18, 1.7 μm (100×2.1mm), with a Mobile-phase-A was ammonium bi carbonate and Mobile-phase-B was acetonitrile in gradient elution mode at a flow rate of 0.3 ml/min and injection volume is 2.0 µL. Quantification of impurities was carried out using triple quadrupole mass detection with electrospray ionization in multiple reaction monitoring mode. The method was fully validated with good linearity over the concentration range of 0.23 to 1.69 μg/g of the Darunavir propylene glycolate test concentration for all Genotoxic impurities. The correlation coefficient obtained in each case was 0.999. The recoveries were found satisfactory over the range between 98.1 to 101.4% for all selected impurities. A novel selective, highly sensitive and hyphenated analytical method using LC-MS/MS coupled with negative electrospray ionization has been developed for quantification of genotoxic impurities like Nitro benzene sulfonic acid and Methyl-4-amino benzene sulfonate...
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Posted by admin on Jul 31, 2024 in |
Systemic fungal infections, including opportunistic and endemic mycoses, pose a significant threat to immunocompromised individuals. Mucormycosis, caused by zygomycetes, is particularly devastating, characterized by tissue necrosis and diverse clinical manifestations. Risk factors such as immunodeficiency and underlying diseases contribute to its incidence. Through a comprehensive literature analysis, this review examines existing data on mucormycosis biomarkers. Treatment typically involves aggressive antifungal therapy and surgical debridement. Promising biomarkers like galactomannan and mannan are identified for early detection and monitoring, crucial for improving diagnostic accuracy and facilitating timely interventions. Pursuing biomarkers for systemic mycoses is crucial for enhancing infection management. Early detection through biomarkers has the potential to decrease morbidity and mortality associated with mucormycosis, ultimately improving outcomes for vulnerable...
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