Posted by admin on Jun 30, 2024 in |
This research investigates the anti-inflammatory potential of Azadirachta indica-loaded microsponges gel, presenting a novel therapeutic approach. The microsponges gel, formulated with Azadirachta indica, aim to enhance drug delivery efficiency for improved anti-inflammatory effects. The microsponges gel is formulated using Carbopol 934P (1% w/v) to optimized encapsulated microsponge. Prepared formulation was evaluated for pH, spreadability, viscosity, and ex-vivo drug deposition study. Characterization studies, in-vitro release assessments, and anti-inflammatory assays contribute to a comprehensive evaluation of the formulated microsponge gel. Preliminary results demonstrate successful formulation of Azadirachta indica-loaded microsponge gel. Characterization studies confirm the structure and composition. In-vitro release studies reveal sustained drug release, and initial anti-inflammatory assays indicate promising activity. This study underscores the potential of Azadirachta indica-loaded microsponge gel as a promising anti-inflammatory therapeutic strategy. The formulation’s sustained release profile and demonstrated efficacy in anti-inflammatory assays pave the way for further investigation and potential clinical...
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Posted by admin on Jun 30, 2024 in |
Food safety is at risk from several variables, including physical, chemical, and biological risks. In this context, biological risks are of utmost significance. The bacteria among them are crucial in producing food deterioration and food-borne illnesses. Additionally, a novel strategy has been applied in recent years that relies on pro-biotic and post-biotic to inhibit the increase of pathogenic microbes and the mediated corruption they cause because of their potent antimicrobial characteristics. The word “postbiotic” designates soluble elements produced by live bacteria or released following bacterial lysis, including enzymes, peptides, teichoic acids, muropeptides produced by peptidoglycans, polysaccharides, cell surface proteins, and organic acids. Postbiotics have a significant potential to be employed in the pharmaceutical, food, and nutraceutical sectors to improve health and disease prevention due to a variety of signaling substances that may have antioxidant, immune-modulatory, anti-inflammatory, antihypertensive, and antiproliferative effects. The current investigation was to determine the antagonistic potential of the secreted probiotic filtrates, also known as postbiotics, generated from some microorganisms against pathogenic microbes such as Candida albicans,...
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Posted by admin on Jun 30, 2024 in |
Natural products have achieved approval globally for assisting healthcare and also disease obstruction. Alkaloids are an important group of diversely distributed, chemically, biologically and commercially significant natural product which have various organic compounds that give different pharmacological activities. The most important and initial step in medicinal plant is extraction because the bioactive compounds need to be extracted from the plant and various techniques are involved like ultrasound assisted extraction, microwave assisted extraction, supercritical fluid extraction, solid phase extraction, liquid-liquid extraction, enzyme assisted extraction etc. alkaloids are obtained from plant, bacteria, fungi and animals. In this paper we gather information about plant alkaloids, classification of plant alkaloids with their different types of extraction techniques, chemical structure and biological sources. Natural products have achieved approval globally for assist healthcare and also disease obstruction. Alkaloids are an important group of diversely distributed, chemically, biologically and commercially significant natural product which have various organic compounds that give different pharmacological activities. Wide range of alkaloids is present in different parts of plants. Different parts...
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Posted by admin on Jun 30, 2024 in |
A simple, precise yet novel UV spectrophotometric method has been developed for the simultaneous estimation of luliconazole and eugenol. Two methods, namely the simultaneous equation method and the absorbance ratio method were tried for simultaneous analysis. Since the simultaneous equation method gave the best recovery; the simultaneous method was developed for the estimation of both drugs. The wavelength of interest is the wavelength maxima of both drugs; λmax of luliconazole 296 nm and λmax of eugenol 282 nm. The correlation coefficient value (r2) was found to be 0.99 for linearity studies both in methanol and phosphate buffer. Validation studies of the developed method were conducted as per ICH guidelines. The method was precise since the percent relative standard deviation was less than 2 and accurate since the percent recovery was between 99.42% and 105.16%. The developed method can be further used for simultaneous analysis of the drugs in bulk and formulation by UV spectroscopy. The development of a suitable analytical method for quantitative estimation is essential for assay and...
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Posted by admin on Jun 30, 2024 in |
Diabetic Peripheral Neuropathy (DPN) is a prevalent and debilitating complication of diabetes mellitus, impacting the global well-being of millions. This review provides a concise overview of the key aspects related to DPN, including its pathophysiology, diagnostic approaches, and current pharmacotherapeutic interventions. The pathophysiology involves intricate mechanisms driven by hyperglycemia-induced oxidative stress, inflammation, and metabolic dysfunction, resulting in peripheral nerve damage. Diagnosis relies on a combination of clinical and electrophysiological assessments. Pharmacotherapy, a pivotal component in DPN management, encompasses analgesics, anticonvulsants, and neurotrophic agents, aiming to alleviate symptoms and impede disease progression. The abstract underscores the need for a multidisciplinary approach and ongoing research to enhance the understanding and treatment of DPN, ultimately improving the quality of life for individuals affected by this...
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