Posted by admin on May 31, 2024 in |
The present study was conducted with an objective to evaluate the in-vitro antioxidant and hepatoprotective activity of three different medicinal plants. Due to the adverse effects of therapeutic agent with better hepatoprotective activity in modern medicine several plants have been screened for the aforesaid activity during last few decades detailed literature survey revealed that leaves of Aegles marmelos, Lawsonia innermis and Murraya koenigii plants were traditionally used for their liver protective activity. When healthcare providers refer to liver disease, they’re usually referring to chronic conditions that do progressive damage to your liver over time. Chronic liver diseases are not uncommon worldwide and are characterized by progressive evolution from steatosis to chronic hepatitis, fibrosis, cirrhosis and hepatocellular carcinoma. There is growing evidence that free radicals and reactive oxygen species play an important role in the progression of liver diseases and thus plants with free radical scavenging activity could play a crucial role in preventing the progression of liver disorders. The results of the present study demonstrate that, all 3 plants...
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Posted by admin on May 31, 2024 in |
Tuberculosis remains a challenge globally affecting the health of several individuals globally. The emergence of drug resistant tuberculosis has further increased the threat. Despite having several drugs available the peril of the mycobacterium continues to loom. Across the globe several scientists are putting in efforts to come up with newer drugs with novel mechanism of action and belonging to several old as well as newer chemical classes. This review article delves in detail on each of the newer drugs discovered for the treatment and control of the disease. It begins with highlighting the progress of the diseases and its treatment over the years and then probes in-depth into the novel molecules of drugs discovered for the same. This article thus is a concise landscape which underlines the need of novel drug molecules and further highlights the potential of these newer drugs to combat tuberculosis by controlling the spread, shortening its treatment period, and making the treatment affordable to...
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Posted by admin on May 31, 2024 in |
Amoxicillin Trihydrate is an extensively used antibiotic, and the accurate determination of its content in bulk and pharmaceutical dosage forms is of greatest importance. This thesis focuses on the development and validation of a High-Performance Thin-Layer Chromatography (HPTLC) method for the analysis of Amoxicillin Trihydrate. The study begins with an inclusive review of the existing analytical methods for Amoxicillin Trihydrate, highlighting the advantages and limitations of each technique. HPTLC is selected as the method of choice due to its simplicity, cost-effectiveness, and potential for routine analysis in pharmaceutical laboratories. The Chromatographic separation was carried out on Merck, Germany, TLC plates of silica gel 60 F254, 10 cm x10 cm using n-Hexane: ethyl acetate in the ratio of 7:3 (% v/v) as a mobile phase followed by densitometric measurements at 230 nm. The following method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification, and specificity according to the ICH (International Conference on Harmonization) guidelines. The calibration curve and results were found to be linear...
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Posted by admin on May 31, 2024 in |
Day by day it is challenging to prepare a chemical reagent against antimicrobial resistant pathogenic for pharmaceutical and food sector. There are several types of quantum dots are invented among them Sulfur Quantum Dots (SQDs) a new type of luminescent quantum dots which is prepared from unused sublimed sulfur can be replaced for these purposes. SQDs are highly water soluble, low toxicity and have an antimicrobial and antioxidant activity. There are several uses of this quantum dots, but in this review the synthesis method and their comparison, antibacterial and antifungal activity and antioxidant activity are described from its invention to present state. SQDs with packaging film exhibited effective antimicrobial effects especially against foodborne microorganisms caused by the production of reactive oxygen species (ROS). SQDs could be a potential agent for food packaging, disinfectant for fabric and increase the shelf life of...
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Posted by admin on May 31, 2024 in |
Levodopa suffers from low oral bioavailability and less than 1% of the drug reaches the brain because of its peripheral degradation. This study aimed to prepare a nasal in-situ gel of levodopa and carbidopa to provide prolonged drug release, improve bioavailability, and increase drug uptake by the brain. Preliminary studies were carried out using different polymers. The concentration of polymer to be employed for the development of the formulations was deduced by carrying out placebo studies (F1-F12). All the batches were assessed for various parameters such as pH, viscosity, gelation time, and mucoadhesive strength. Out of 12 placebos, F11 which is pH and ion dual activated in-situ formulation showed satisfactory results. Therefore, F11 formulation was selected to prepare levodopa and carbidopa nasal in-situ gel. Drug incorporated formulation was found to have a viscosity of 2870.13 cps, assay of 95.7% of levodopa and 100.83% of carbidopa, and gelation time of 35 s, and the in-vitro drug release of levodopa and carbidopa after 8 h is 95.7% and 99.38%, respectively. Ex-vivo...
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