Posted by admin on Apr 30, 2024 in |
The need to deliver pharmaceuticals to patients quickly and with minimal side effects has driven pharmaceutical companies to invest in the development of novel drug delivery systems. Solid dose forms, such as pills, are difficult for pediatric and geriatric patients to swallow. The best treatment for this issue is a mouth dissolving pill that dissolves or disintegrates quickly in the oral cavity. Additionally, they produce a pleasant tongue sensation. ODT has benefits like enhanced Bioavailability, rapid action, and patient compliance. As a result, mouth-dissolved tablets are a desirable substitute for liquid and traditional tablet dose forms. In recent past, several manufacturing technologies such as sublimation technique, spray drying technique etc. are employed to overcome the limitations of conventional tablet dosage forms. The mouth dissolving tablets must undergo a variety of evaluations after they are created in order to ensure their long-term stability and improved therapeutic...
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Posted by admin on Apr 30, 2024 in |
Wound infections persist as a significant and persistent challenge within the realm of healthcare, posing numerous detrimental consequences that extend far beyond the affected individuals. These infections, characterized by the infiltration of harmful microorganisms into wounds, encompass a multifaceted predicament that engenders slower healing periods, heightened morbidity rates, and an onerous financial burden on healthcare systems worldwide. Bacteriophages often known as phages, are viruses that selectively target and eradicate bacteria, making them a potentially effective alternative or supplementary treatment for wound infections. This article gives a general summary of what is currently known about using bacteriophages topically to treat wound infections. It goes through the fundamentals of phage treatment, looks at the benefits and drawbacks of phage use, examines the preclinical and clinical data that is now available, and identifies future research paths in this area. The review highlights the potential of bacteriophage-based therapeutics to transform the treatment of wound infections and provides information on the crucial factors to take into account for effective...
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Posted by admin on Apr 30, 2024 in |
Around the world, cancer frequently leads to death. Lung cancer is the primary cause of cancer-related deaths globally. Through in-silico analysis, this study sought to assess the anticancer effectiveness of myricetin on human lung cancer cells. The study’s goal is to assess how well myricetin adheres to the Lipinski rule of 5. To evaluate the ADMET properties (Absorption, Distribution, Metabolism, Excretion, Toxicity) for myricetin. To predict the target-ligand interaction. The results from these studies supported that the myricetin follows the Lipinski rule of 5 and ADMET properties. Myricetin has a better H bond interaction. The results of the in-silico analysis used in this work serve as encouraging evidence for the prediction of the mechanism by which myricetin acts to cause apoptosis via the EGFR pathway. The results from the molecular docking study suggested that myricetin inhibited critical tumorigenic effects through apoptosis. Thus myricetin could be further explored as a promising chemotherapeutic agent in lung cancer...
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Posted by admin on Apr 30, 2024 in |
Testicular toxicity has been associated with long-term paracetamol usage. Moringa oleifera is known to eliminate toxins from organs and restore functionality. This study seeks to ascertain the potency of moringa in ameliorating paracetamol-induced testicular toxicity. Forty nine (49) Sprague-Dawley rats were randomly assigned into seven (7) groups composed of 7 rats each treated for 5 weeks. One group served as the control, while 3 other groups were administered graded doses of paracetamol, then the other 3 groups were administered graded doses of paracetamol and 1600mg/kg of moringa extracts simultaneously. The animals were sacrificed 24 hours after the administration of last dose using anaesthesia. The testes and epididymis were harvested, while blood was obtained via ocular puncture. The moringa extract mitigated the paracetamol-induced dose-dependent decrease in sperm count and sperm morphology. Paracetamol toxicity on hormonal milieu was suppressed by the moringa extract treatment, yielding hormonal values closer to those obtained in the control group. The moringa extract treatment controlled the oxidative stress biomarkers as their values were not as variant...
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Posted by admin on Apr 30, 2024 in |
Objectives: To study potentiation of hypoglycaemic effect of Glimepiride with combination of Selenium, Zinc, Vitamin C and Vitamin E on Streptozotocin induced diabetic rats and to compare potentiating hypoglycaemic effect of above-mentioned drugs with that of standard diabetic control group. Methods: Study was carried out in Research Laboratory, Department of Pharmacology, BIMS, Belagavi. Albino rats weighing 200-250g were used. Streptozotocin was administered intraperitoneally for induction of type 2 diabetes. Each diabetic rat was fed orally with test drugs once daily for 21 days. Blood glucose levels were monitored on first day and at end of study. Results: Administration of glimepiride caused a decrease in blood glucose levels which is statistically significant (Group 2 vs 3, p=0.004).Combination of glimepiride, selenium, vitamin C and E decreased blood glucose levels to lower level than glimepiride alone (Group 3 vs 4, p = 0.016). Combination of glimepiride, zinc, vitamin C and E decreased blood glucose levels to lower level than glimepiride alone (Group 3 vs 5, p = 0.006). Combination of glimepiride, selenium,...
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