Posted by admin on Apr 30, 2024 in |
Buccal drug delivery is the most suited route for local as well as systemic delivery of drugs. The purpose of this study was to develop and optimize formulations of mucoadhesive tablets of Cilnidipine with an objective to enhance therapeutic efficacy, bioavailability and was developed to administer into the unconscious and less-co-operative patients. Cilnidipine buccal tablets were prepared by direct compression method using various concentrations of mucoadhesive-polymers such as Carbopol and Hydroxyl propyl methylcellulose (HPMC) the Prepared Tablets were evaluated for their weight variation, Hardness, thickness, Friability, swelling-index, drug content uniformity and in-vitro release studies. The infra-red (IR) spectra showed no interaction, and Physico-chemical characteristics were found within the limit. Swelling index increases with increasing concentration of polymers. The formulation F8 showed a promising Bio adhesive strength and in-vitro drug release of 98.29% for 8 hrs thus can be selected as an optimized formulation of mucoadhesive buccal...
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Posted by admin on Apr 30, 2024 in |
The utilisation of electroceuticals in the treatment of Parkinson’s disease is the predominant topic of discussion in this review. Electroceuticals, which are frequently referred to as “bioelectronics medicine,” are the result of the utilisation of electrical impulses for the goal of therapeutic treatment. It has been investigated if electroceuticals could serve as an alternative or adjuvant to the conventional pharmaceutical therapies that are used in the treatment of Parkinson’s disease. The purpose of this review is to conduct a comprehensive analysis of the existing literature concerning a variety of electroceutical modalities. These modalities include deep brain stimulation (DBS), vagus nerve stimulation (VNS), and transcutaneous nerve stimulation (TNS), amongst others. An analysis is performed to determine the efficacy and safety of various methods, as well as to determine their limitations and potential future research areas. While the review comes to the conclusion that electroceuticals have the potential to be an advantageous addition to the arsenal of Parkinson’s disease treatments, it is important to note that further research is required to...
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Posted by admin on Apr 30, 2024 in |
The objective of chronotherapy is to optimize medical treatments taking into account the body’s circadian rhythms. Drug delivery systems that precisely control the release rates or target drugs to a specific site have an enormous impact on the health care system. Over the past few years, pharmaceutical industry has focused its research in the development of various Chrono therapeutic delivery systems. By choosing the optimal time to achieve the desired effect, treatment opportunities may arise, and undesirable side effects minimized. Hence, the long-term interest of both the public and the industry is to develop new and more effective methods on the current study focus – Chrono pharmaceuticals. The present article covers findings about the effects of biorhythms on various disorders, and their implications for drug therapy and also the design of novel chrono pharmaceutical drug delivery systems that might be able to release the therapeutic agents at predetermined...
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Posted by admin on Apr 30, 2024 in |
Children under five years of age, with severe or cerebral malaria, cannot consume oral medication especially if they are vomiting or are unconscious. In such situations they are given an injectable drug until they can tolerate oral medication. The situation is bad in Sub-Saharan Africa, especially in rural areas as children are sometimes referred to the closest referral health care facility for proper management. The aim of this study was therefore to conduct a pilot study to estimate the bioavailability of lumefantrine (LF) when administered as a rectal enema, and compare it with a commercially available oral suspension, in rabbits. The study was conducted on six healthy rabbits in an open randomized, crossover three sequence, single dose study, where each rabbit received rectal and oral formulations. The oral formulation was administered under fed and fasted conditions. A two-week washout period was allowed between the experiments. LF was quantified in rabbit plasma using ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Results showed that the relative bioavailability of rectal LF was...
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Posted by admin on Apr 30, 2024 in |
The present study involves the formulation development and in-vitro evaluation of benidipine hydrochloride buccal tablets. Designed to prolong the time of release of drug and also to enhance the better bio-availability of the drug. Benidipine hydrochloride is a long-acting calcium channel blocker. It exerts its antiangial, antihypertensive action through blocking the influx of ca ions through voltage gated L-type ca channels to the pheripheral vascular smooth muscle cells, coronary smooth muscle cells and to the myocardial cells. And having biological half life 1-2 hrs, extensive protein binding need to formulate an dosage form. Benidipine hydrochloride buccal tablets were prepared by using direct compression method. Total eight formulations were prepared by using different polymers viz., Sodium alginate, Chitosan, Carbopol 934, HPMC, in various ratios. The nature of the polymer influences the physical and release characteristics of the buccal tablets. Preformulation studies were carried out before formulation design. Preformulation results showed good flow properties and all results are within specified limits. Compatibiity for drug and excipient was carried by FT-IR and...
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