Posted by admin on Nov 30, 2024 in |
Diltiazem HCl is a newer class of antiarrhythmic agent and available in market tablets as a controlled and extended-release formulation. The release pattern is influenced by atmosphere, pH, the presence of food and other physiological conditions of GI tract. This is possible by formulating and osmotic tablets. A controlled porosity osmotic tablet of diltiazem HCl was formulated by incorporating leachable polymer Eudragit in a PEG-400 semipermeable coating membrane. The core tablet was prepared using the drug, mannitol, MCC, PVP K-30, talc and mg. stearate. The core tablet was evaluated using bulk and tapped density, carr’s index, angle of repose, hardness, weight variation, in-vitro dissolution. The thickness of PEG-400 coating was optimized to give a desired release of drug. The drug release study was done by USP-II dissolution apparatus (paddle). 23 factorial design used to optimized the formulation. The release pattern was concluded from kinetics models as a zero-order release. Osmotic tablet of diltiazem can be successfully formulated using diltiazem HCl (120mg), HPMCK100M (100mg), PEG 400(20%), mannitol (3.5mg) giving 6%...
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Posted by admin on Nov 30, 2024 in |
Wound healing remains a significant challenge in modern medicine, necessitating the exploration of innovative therapeutic strategies. Centella asiatica, a widely recognized medicinal herb, has garnered attention for its potential wound healing properties. This study aimed to investigate the efficacy of a Centella asiatica transdermal patch in promoting wound healing. These results suggest that the Centella asiatica transdermal patch holds promise as a novel therapeutic intervention for promoting wound healing. Further research is warranted to elucidate the underlying mechanisms of action and optimize the formulation of the patch for clinical application. This study contributes to the growing body of evidence supporting the use of herbal remedies in wound management and underscores the potential of Centella asiatica as a valuable adjunctive therapy in wound healing. This study investigates the wound healing activity of a transdermal patch containing a combination of Centella asiatica and Liquorice extracts. The patch was formulated and evaluated for its efficacy in promoting wound healing using in-vitro and in-vivo assays. Overall, this study suggests that the Centella asiatica...
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Posted by admin on Nov 30, 2024 in |
The multifaceted applications of X-ray instrumentation across industrial, medical, forensic, and security domains. In industrial settings, X-ray instrumentation serves as a cornerstone for non-destructive testing, ensuring product quality and streamlining manufacturing processes. In the medical field, these instruments play a pivotal role in diagnostic imaging, offering crucial insights for effective healthcare interventions. Forensic applications benefit from the detailed analysis provided by X-ray instrumentation, aiding in evidence examination and crime investigation. Additionally, X-ray technology strengthens security measures by facilitating swift and accurate detection of potential threats in baggage and parcels. The continuous evolution of X-ray instrumentation promises ongoing innovations, shaping advancements in industrial processes, medical diagnostics, forensic investigations, and security protocols. Contributing to various branches of science and technology, as technology advances the versatility of X-rays continues to expand, making them an invaluable tool across the fields. The abstract highlights the transformative impact of X-ray instrumentation across diverse sectors, emphasizing its historical significance and continued relevance...
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Posted by admin on Nov 30, 2024 in |
Introduction: Malaria is a seasonal disease and endemic in Chhattisgarh, as a large number of cases and deaths are reported from the tribal-dominated districts of Chhattisgarh. The distribution of these malaria parasites can vary across different regions of India due to climate, geography, mosquito vector species present, human population dynamics, and socio-economic conditions. Aims and Objectives: This study was carried out to analyse the trends in the prevalence of malaria parasites from 2018 to 2022in a tertiary care center. Materials and Methods: Retrospective Data from five annual cross-sectional Rapid diagnostic tests for malaria antigen were analysed from a combined sample of 27,844 individuals suspected of malaria. Data collected included demographic profile and test results of malaria parasites by Rapid diagnostic test. Results: The overall malaria prevalence rate detected during the study period was 1.39%. P. falciparum species showed predominance, with a pinnacle of 96.1% (100) in 2020. Malaria cases were found to be more associated with young adults (31.95%) males (62.88%) with peak positivity rate recorded in month of...
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Posted by admin on Nov 30, 2024 in |
Diabetes mellitus can lead to impaired healing of wounds and can cause life-long complications. Curcumin is reported as one of the promising therapeutic agents in the management of impaired wound healing in diabetics. This study aimed to formulate a wound-healing ointment from the extracted curcumin and evaluate its efficacy among diabetes-induced rats. The extract was subjected to organoleptic evaluation, phytochemical screening, pre-formulation studies, and thin layer chromatography. Three trial formulations of ointment were prepared with varying concentrations of the extract. Prior to wound excision, alloxan monohydrate (110 mg/kg) was administered intraperitoneally among thirty male Sprague Dawley rats to induce diabetes. The trial formulations of ointment were then applied in all treatment and control diabetic rat (FBG of > 200 mg/dL) groups for 14 days. The wound-healing activity was assessed through the following parameters: percent wound closure (PWC), period of epithelialization (PE), percentage of scar formed (PSF), and histopathological analysis. Among the trial formulations, 10% extracted curcumin ointment exhibited the highest PWC, fastest rate of wound closure, shortest PE, and...
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