Posted by admin on Apr 30, 2024 in |
An easy, precise and accurate spectroscopic technique for the simultaneous estimation of nicotinamide and metronidazole in semi-solid dosage form and in bulk form has been developed. The present method involves the addition of 0.1M hydrochloric acid solution, followed by dilution with water and subjecting the resulting solution to UV spectroscopic assessment. Absorption maximum was found to lie at about 262 nm and 317 nm for nicotinamide and metronidazole respectively. The calibration curve showed linearity as per line equation y=0.0029x + 0.0001 with an R2value of0.9937 for nicotinamide and y = 0.0072 x + 0.0063 with an R2 value of 0.9933 for metronidazole. Validation was performed as per ICH guidelines for linearity, accuracy and precision. The assay result was in a good arrangement with the label claim. The mean Sandell’s sensitivity values for metronidazole and nicotinamide, respectively, were 0.354 g/cm2 and 0.134 g/cm2, showing that the approach is very sensitive and practical for measuring both...
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Posted by admin on Apr 30, 2024 in |
A simple, rapid, precise, sensitive and reproducible Reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the quantitative analysis of Tepotinib in presence of its impurities (1&2) in pharmaceutical dosage form. Chromatographic separation of Tepotinib and its known impurities were achieved on Waters Allianace-e 2695 by using Inertsil ODS C18 250×4.6mm 5µ column and the mobile phase containing (0.01M) KH2PO4 PH-2.5&Acetonitrile in the ratio of 50:50% v/v. The flow rate was 1.0ml/min; detection was carried at 263nm using a photodiode array detector at ambient temperature. The calibration range was 10-60µg/ml for Tepotinib, 2.5-15µg/ml for Imp-1& 3.75-22.5µg/ml for Imp-2. %Relative standard deviation of peak areas of all the measurements less than 2%. Recovery was obtained between 98-102%. Stability studies were also performed with known impurities the drug showed maximum degradation in alkaline stress condition. The proposed method was validated according to ICH guidelines. The results obtained were within the acceptable limits. The proposed method was found to be simple, economical, precise, accurate & robust for quantitative analysis...
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Posted by admin on Apr 30, 2024 in |
Endocrine-disrupting chemicals are environmental pollutants that have been associated with a wide range of diseases, including breast cancer, the most prevalent cancer in women worldwide, according to the WHO. Among the different cancers affecting the female population, breast cancer has the highest incidence and mortality rate. The incidence of breast cancer is 100 times higher in women than in men. The incidence of breast cancer is alarmingly high, so the need for a novel approach with fewer side effects is currently needed to improve the quality of life of the patients. Catharanthus roseus is a plant species belonging to the Apocynaceae family that is used worldwide in phytotherapy. The indolic alkaloids (vincristine and vinblastine) isolated from C. roseus are approved and used in clinical trials. The interest of the study lies in the comparison of indole alkaloids (vincristine and vinblastine) against breast cancer targets through in-silico studies. The work of the study lies upon downloading target and ligand. The targets that are associated with breast cancer were downloaded from...
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Posted by admin on Apr 30, 2024 in |
Periodontitis is a widespread oral gum infection having multiple antibiotics for the treatment, but large oral doses and the emergence of antibiotic resistance constrain their usage. The goal of this study was to develop and characterize buccal mucoadhesive patches made of clindamycin and polymers for the treatment of Periodontitis. Patches were developed by solvent casting method using Clindamycin Hydrochloride, an herbal constituent of Curcumin, and polymers like Polyvinyl Alcohol, and Hydroxy Ethyl Cellulose. Eight trial patches were developed by keeping the drug ratio constant and varying the concentration of different polymers. The optimized patch concentration was chosen to formulate the buccal mucoadhesive patch to treat periodontitis. Optimization was conducted by Design Expert Software (DoE) using 23 full factorial designs by taking three independent variables as factors and two dependent variables in-vitro Drug release (Y1) and Drug content (Y2). Prepared buccal mucoadhesive patches were flexible and showed the highest efficacy in the inhibition of oral microorganism species like Porphyromonas, Streptococcus, Actinomyces, and Candida albicans. The optimized patch was analyzed for...
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Posted by admin on Apr 30, 2024 in |
The demand for Mouth Dissolving Tablet has been increasing for the last decade particularly in geriatric, peadiatric and patient with some sort of disabilities in swallowing. Mouth dissolving tablets are those tablets which when placed in mouth get dissolved rapidly in saliva without the need of liquid and can be swallowed. European pharmacopeia adopted the term Oro-dispersible tablet for MDTs. Mouth dissolving tablets are also known as Fast melting tablets. Oro-dispersible tablets, fast dissolving tablets or melt in mouth tablets. This article reviews the potential benefits offered by MDTs as a oral drug delivery system for various kinds of patients suffering from different diseases and disabilities. Desired characteristics and challenges for developing fast disintegrating drug delivery systems, quality control tests, various techniques used in the preparation of fast disintegrating drug delivery systems like lyophilization technologies, tablet molding method, sublimation techniques, spray drying techniques, direct compression method. It also reviews the patented technologies for fast dissolving tablets, advantages and disadvantages of different technologies for preparing fast disintegrating dosage form, future...
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