Posted by admin on Apr 30, 2024 in |
A new HPLC method has been developed and validated for the simultaneous estimation of Rifampicin and Isoniazid, offering a reliable and efficient approach for their analysis. The method employs a mobile phase composed of pH 3.5 phosphate buffer, methanol, and water in a 45:30:25 ratio. It demonstrates a linear response for both drugs within specific concentration ranges, allowing for accurate quantification. Detection is performed at 239 nm, with retention times of 2.8 minutes for Rifampicin and 3.7 minutes for Isoniazid. Accuracy studies have shown excellent recovery rates within ICH guidelines, ensuring the reliability of the results. Notably, the method exhibits high precision with RSD values within acceptable limits, indicating its reproducibility. It has also been found to be simple, rapid, robust, and reproducible, making it well-suited for routine use. This validated HPLC method holds significant potential for both pharmaceutical and clinical applications, enabling accurate and efficient analysis of Rifampicin and Isoniazid in bulk and tablet dosage...
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Posted by admin on Apr 30, 2024 in |
In response to the increasing popularity and greater demand for medicinal plants, several conservation groups recommend cultivating wild medicinal plants. Green Tea is among the most ancient and popular therapeutic beverages worldwide. This product is made from the plant leaf called “Camellia sinensis.” It can be prepared as a drink, which can have many systemic health effects or an “extract” can be made from the leaves for medicine. Green tea contains thousands of bioactive ingredients, which are almost contributed by polyphenols, which play a key role in preventing and treating many diseases. This literature review aimed to illustrate the phytoconstituent and marketed products of the plant “Green...
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Posted by admin on Apr 30, 2024 in |
Diabetes Mellitus is characterized as metabolic chronic disease spreading all over the world ata high pace. Due to its speedily wide population spreading it is termed as 3rd most populated country in the world since the number of individuals diagnosed with diabetes is just behind population of China and India. To date treatment therapy concerning diabetes majorly responds to insulin-dependent mechanisms. A newer activity regarding renal glucose mechanism highlights a novel treatment to curtail diabetes. Filtered glucose gets transported through the kidney, when reaches proximal tubules further reabsorbed through sodium glucose co-transporter-2 [SGLT-2] and elevates blood glucose level. SGLT-2 inhibition provokes a new treatment for diabetes and Empagliflozin, a novel, potent SGLT-2 inhibitor class drug and compare to other drugs of this class, Empagliflozin exerts a favorable once-daily dose and negligible risk of hypoglycemia. On the other hand, Sitagliptin is a DPP-4 inhibitor and has a significant role in the improvement of activity of GLP-1 situated in the myocardium pathway, an incretin hormone which got released from intestinal L...
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Posted by admin on Mar 31, 2024 in |
Background: Fatigue is a common symptom in patients with advanced kidney disease, with implications for quality of life and clinical outcome. Fatigue is one of the most frequent complaints of dialysis patients and is associated with impaired health related quality of life (HRQOL). Aim: To monitor and measure the severity of fatigue in dialysis and non-dialysis patients of chronic kidney disease. Methodology: This prospective study was performed in the Department of Nephrology in SVIMS, Tirupati, over a period of 6 months. In this study, Fatigue Severity Scale was used with help of questionnaire form. Results: A total of 30 patients were recruited in this study based on their type of dialysis and we categorized subjects based on Gender, Age, Occupation, CKD Stage, dialysis per week, family history, complications and duration of CKD. We found that average fatigue score in Non-Dialysis subjects is 4.80±1.989, Hemodialysis subjects is 4.20±1.033, Peritoneal dialysis is 2.80±1.476. Conclusion: Our study concludes that patient having comorbidity condition like only Hypertension and Hypertension with Diabetes mellitus were...
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Posted by admin on Mar 31, 2024 in |
Sarcocephalus latifolius have a wide range of medicinal applications. This study evaluated the neurobehavioural activity of crude Leaf extract of Sarcocephalus latifolius on wistar rats and the effect on the histoarchitecture of the temporal lobe. Sixteen adult Wistar rats were divided into four groups of four rats each. Group A served as the negative control and received distilled water, B and C served as the experimental group and received 100mg/kg and 150mg/kg of the extract, while D served as the positive control and received 2.5mg/kg of diazepam. The administration lasted for two weeks and the neurobehavioural activity of the extract was explored using elevated plus maze. After the test the rats were sacrificed and the brain harvested, fixed and processed using normal histological techniques. In the elevated plus maze, the experimental group showed increased open entry, when compared to the negative control but less than the positive control, which is a measure of its anxiolytic activity. The extracts altered the microanatomy of the temporal lobe, in dose dependent manner....
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