Posted by admin on Mar 31, 2024 in |
Hepatitis B, Diabetes, Alcoholic and Non-alcoholic Fatty Liver Disease, Cholangiocarcinoma, Cholangioleiomyopathies, and other risk factors for hepatic illness are all becoming more harmful nowadays. In animals, the dysfunction of melatonin levels and an unbalanced circadian rhythm can control physiological processes and cellular mechanisms during periods of rest and activity. The Suprachiasmatic Nucleus (SCN) in the Hypothalamus of the Brain and Melatonin production in the pineal gland control circadian rhythms and clock gene expressions. The main purpose of the study is to summarise the most recent research on the molecular mechanisms underlying Circadian Rhythm, including the core clock genes and melatonin release, and their relationship to chronic liver diseases. Also covered were the future methods for studying Circadian Rhythm’s Chronopharmacological Aspects for the Treatment of Hepatic...
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Posted by admin on Mar 31, 2024 in |
The aim of the article is to formulate and evaluate emulsion also perform comparative study with marketed formulation. Emulsion is a heterogeneous system consisting of at least one immiscible liquid dispersed in another in the form of droplets. Emulsion is prepared with castor oil and liquid paraffin. One marketed formulation was taken for comparison. Identification tests, evaluation tests and stability studies were performed. The emulsion was evaluated by the parameters like pH, viscosity and organoleptic properties. The stability study was performed by testing pH and viscosity. The results of the study showed the good organoleptic properties, pH,...
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Posted by admin on Mar 31, 2024 in |
Thespesia populnea Linn., a member of the Malvaceae family also known as Portia tree, a plant commonly found in coastal and tropical regions of India. Its therapeutic properties have been recognized in ayurvedic medicine, which has been validated by modern scientific research. This paper highlights the chemical constituents and pharmacological profile of Thespesia populnea. The plant has shown remarkable potential as an anti-inflammatory, antidiabetic, antimicrobial, antipsoriatic, antidiarrheal, anti-implantation, anticancer, and alzheimer’s disease management agent etc. Its extracts also exhibit a synergistic activity with oxytetracycline, a commonly used antibiotic. Additionally, the plant is used as a natural dye for various fabrics, a source of biodiesel and an anti-corrosive agent. Phytochemical analysis has exposed the presence of alkaloids, sesquiterpenoids, fatty acids, polysterol, glycosides and alkane in various extracts of the plant. These bioactive compounds are responsible for the diverse pharmacological activities exhibited by Thespesia populnea. The review provides advanced evidence to support the traditional knowledge of Thespesia populnea and highlights its potential as a source of novel drugs for various diseases....
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Posted by admin on Mar 31, 2024 in |
A simple, sensitive, robust and specific high performance liquid chromatographic (HPLC) method was developed and validated for the simultaneous determination metformin and levothyroxine in human plasma. In the current study, the analysis was performed on Phenomenex Luna 5µ C18 100A (250 x 4.6mm, 5 micron) column using acetonitrile: methanol: 0.03M phosphate buffer (pH 2- 3.5) 50:10:40 v/v/v as mobile phase at flow rate 1.0 mL/min. The analytes were monitored with UV-PDA detector at 251nm. In this developed method Metformin and Levothyroxine elutes at a retention time of 2.698 and 5.929 min respectively. The proposed method is having linearity in the concentration range from 5 to 50μg/mL of Metformin and Levothyroxine. The current method was validated with respect to linearity; precision, lowest limit of detection (LOD) and lowest limit of quantification (LOQ), accuracy and recovery according to the USP guidelines. The system consisted of a pump (Shimadzu, prominence, HPLC), with 20µl sample injector, along with a PDA detector at a wavelength of 251nm. Data was compiled using Shimadzu LC Solution...
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Posted by admin on Mar 31, 2024 in |
Medical device, a device or instrument or apparatus or that is used to treat or prevent or diagnose or mitigate or cure the disease or to replace the structure of the body parts mimicking the natural function. The medical device sector started to grow rapidly in the last 8 years. Developed countries like the USA, European Union, and Japan concentrated on this sector to increase their production capability, and regulations were stringent to prevent unlawful happenings. India still lags in the development of the medical device sector. Earlier the rules and regulations for medical devices in India were followed the same as the drugs and cosmetics, which raised various questions regarding the regulatory process of medical devices. Very later the Medical Device Act 2017 was introduced which explained the manufacture, import, export & clinical investigation regulatory process required for a medical device. The Medical Device Act 2017 is framed as competent with the other national authority regulators and internal medical device regulator forums. This paper discusses the Medical Device...
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