Posted by admin on Mar 31, 2024 in |
Indian spices and medicinal herbs are well known throughout the world. Both have many different physiological and pharmacological characteristics. The current biomedical research is mostly concentrated on finding chemicals extracted from natural sources that are pharmacologically efficient and have little to no side effects for application in food production and preventative medicine. Pepper (Piper nigrum) is a common spice found in both Eastern and Western cuisine. It helps in digestion and weight loss by encouraging the breakdown of fat cells and has a remarkable antioxidant and antibacterial impact. Numerous independent researchers have conducted experiments that show pepper and its main ingredient, piperine, to have a variety of physiological effects. In-vitro studies have shown that piperine can prevent oxidative damage by suppressing or inhibiting harmful free radicals and oxygen compounds that are reactive. Apart from anti-oxidant property, analgesic, anti-inflammatory, anti-diarrheal, antispasmodic, antidepressant, immunomodulatory, anticonvulsant, anti-thyroid, antibacterial, antifungal, hepato-protective, insecticidal, and larvicidal activities are just a few of the potential pharmacological effects of Piper nigrum L and its active component, “Piperine,”....
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Posted by admin on Mar 31, 2024 in |
The study focuses on creating and evaluating a specialized bilayer tablet for treating hypertension. It begins with in-depth preformulation analyses of key components like Atenolol, Hydrochlorothiazide, and various excipients. Special emphasis is placed on optimizing the powder blend’s flow properties to facilitate tablet compression. A series of tests on resulting tablets (F1 to F8) assess weight variation, thickness, hardness, friability, disintegration time, and drug content, ensuring they meet required specifications with uniform weight and hardness. Dissolution profiles of all formulations are examined, with Formulation 8 (F8) identified as the most suitable for consistent drug release across both layers. The study investigates drug release mechanisms, finding that both layers adhere to the diffusion-controlled release model, particularly the Higuchi model. Stability tests conducted under elevated temperature and humidity (40°C/75% RH) over three months reveal minimal changes in physical attributes, drug content, and drug release profiles, confirming the tablet’s stability. In conclusion, the study successfully develops an optimized Immediate Release Bilayer Tablet containing Atenolol and Hydrochlorothiazide. This tablet offers controlled and uniform...
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Posted by admin on Mar 31, 2024 in |
This systematic review provides a comprehensive overview of recent advancements in liquid crystalline nanoparticles (LCNs) utilized for transdermal drug delivery systems. Recent literature indicates a surge in research emphasizing lipid carriers derived from glyceryl monooleate and monoolein. The inherent nanostructure of LCNs offers superior solubilization capacity for bioactive molecules and controlled release mechanisms. This study underscores the potential of the cubic phase in LCNs as an innovative avenue for sustainable Transdermal Drug Delivery Systems (TDDS). Recent studies highlight the growing interest in cubosomes and hexosomes. Critical analysis necessitates further exploration into the therapeutic efficacy of Alpha lipoic acid cubosomes for anti-wrinkle applications, and the viability of hexagonal phase nano dispersions for in vivo peptide and siRNA delivery. A bibliometric assessment points out China as the leading contributor to LCN-centric publications. To summarize, LCNs are poised as potent TDDS, warranting future exploration in live skin imaging and immunological evaluations in animal model studiesproperties thus increasing residence time of drug with better patient...
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Posted by admin on Mar 31, 2024 in |
Moringa oleifera leaves, have a high antioxidant content, which is beneficial for overcoming free radicals in the body. The leaves contents have the potential to be developed into a functional drink in the form of effervescent granules. The important aspects influencing the acceptability of granule is the type and ratio of the effervescent agent. In this study, citric acid and sodium bicarbonate were used as effervescent agents because they both provide acceptable texture and mouth feel. This study aimed to develop an effervescent granules formulation of Moringa oleifera leaf extract and to optimize the molar ratio of citricacid and sodium bicarbonate as the effervescent agent. Three formulations using different ratios of citric acid and sodium bicarbonate were selected, namely F1, F2 and F3. These formulations were developed using the wet granulation method. The results showed by effervescent granules of the three formulations exhibited good flow ability and good particle size distribution. The organoleptic and sensory evaluation results showed formulation F3 was the most acceptable in terms of colour, taste,...
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Posted by admin on Mar 31, 2024 in |
Introduction: The analgesia effect of anesthetic drugs namely Ropivacaine, can further be enhanced with adjuvants. For postoperative pain management in infra-umbilical surgeries, Ropivacaine with an adjuvant can be used through a Transversus Abdominis Plane (TAP) block, which is a simple and clinical anatomical landmark procedure, suitable in remote areas without advanced modern technical tools. Aims: Fentanyl and Dexmedetomidine (Dexmed) were used as adjuvant to Ropivacaine, injected in TAP, postoperatively, and were compared in terms of pain relief. Material & Methods: In this randomized comparative study, undertaken from January 2021 to August 2022, 60 patients were randomly divided into two groups of 30 each, Group A- Injection Fentanyl (25 mcg) + Ropivacaine (0.375%) in 20ml dilution and Group B- Injection Dexmed (25 mcg) + Ropivacaine (0.375%) in 20 ml dilution were injected in TAP block on either side. The outcome was studied at 3, 6, 9, 12, and 24 hours, postoperatively. Results: The mean duration of analgesia in patient’s of group B was higher and statistically significant (“p-value”<0.001) than group-A....
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