Posted by admin on Mar 31, 2024 in |
Okra (Abelmoschus esculentus (L.) Moench.) is an important nutrient-rich vegetable crop also known as “lady’s finger”, widely grown in the tropics and sub-tropics mainly for its edible pods and is an alloploid. The haploid technique has been used in plant breeding for the improvements of plants and to develop new varieties in a relatively short time. Hence, we have optimized several factors such as plant growth regulators (PGR), sucrose concentration, type of media and culture conditions for callus induction from the anther and ovary of okra (Parbhani Kranti Hybrid). In this research, the effects of the microspore developmental stage, time of bud collection, different combinations of hormones, and culture condition on anther culture were studied. The explants were cultured on various combinations of PGRs i.e., (IAA, 2,4-D, KIN, BAP, IBA and TDZ) and various concentrations. The optimum developmental stage of microspore for callus initiation was achieved from flower buds of okra and its size was about 12 mm long, and showed significantly higher percentage of callus induction. The optimum stage for...
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Posted by admin on Mar 31, 2024 in |
This study focused on the development and evaluation of solid dispersions of Tinidazole, aimed at creating a fast-release tablet formulation. The preparation involved using carriers such as PEG 4000 and HPMC. Solid dispersions were created using both solvent evaporation and fusion methods. The resulting solid dispersions exhibited desirable properties, appearing as fine and free-flowing powders. Interaction studies, including IR spectra analysis, revealed no significant interaction between the drug and the carriers employed. Furthermore, uniform drug content was observed across all prepared solid dispersions. Correlation studies between the percentage of carriers in the dispersions and the dissolution behavior of pure Tinidazole indicated a positive relationship. Dissolution kinetics analysis demonstrated that the release of Tinidazole from all dispersions adhered to first-order kinetics. Notably, PEG 4000 emerged as the most effective carrier, yielding the fastest dissolution rate. The sequence of dissolution rates from various solid dispersions was determined. To extend the evaluation, Tinidazole solid dispersions in a 1:2 drug-to-carrier ratio with PEG 4000 were formulated into capsules. These capsules exhibited significantly enhanced...
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Posted by admin on Mar 31, 2024 in |
Objective: During the reproductive years, diabetes has been associated with menstrual abnormalities, sexual dysfunction and increases infertility rates among females. Strychnos potatorum Linn (S. P. Linn) has been recognized as antidiabetic drug as an Ayurveda medicine. This study was done to estimate whether S. P. Linn can control diabetes and prevent diabetes related complication in the reproductive system of female rats. Method: Experiments were carried out on 36 inbred female rats (150-200 gm) for studying the effect of the indigenous plant product on diabetic animal model. Six animals per cage were housed at room temperature with standard laboratory rodent pellet diet and water was allowed ad libitum. All animals were made diabetic by a single intraperitoneal Streptozotocin (STZ) injection at 40 mg/kg body weight, and then divided into six groups. Fasting blood sugar was estimated at biweekly interval. All the animals were sacrificed after three months. Uterus with fallopian tube and ovary were separated & weighed after sacrificing the animal on day 90. Ovary and vagina was collected for...
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Posted by admin on Mar 31, 2024 in |
Cancer is the uncontrolled growth of abnormal cells in the body. It is the second leading cause of death globally, accounting for an estimated 9.6 million deaths in 2018. Topoisomerases are important cellular targets especially in the treatment of human cancers. They are of two types mainly topoisomerase II alpha and beta. Some of the most powerful anticancer drugs used clinically such as etoposide, teniposide, doxorubicin, daunorubicin, mitoxanrone, Amascarine etc act by causing DNA disorders. Topoisomerase II alpha is the target of action selected in this present study. Doxorubicin, one of the potent anticancer drugs that can be used to treat many cancers by acting on topoisomerase II alpha. Benzimidazole and pyrazole is an organic compound that is heterocyclic in nature. These are important pharmacophores and privileged structures in medicinal chemistry. It possess pharmacological activities such as antimicrobial, antiviral, anticancer, antiinflammatory, analgesic, antifungal, antitubercular, anti-convulsant, ACE-inhibitory etc. This study evaluates the anticancer activity of benzimidazole and pyrazole hybrid derivatives on 4FM9 using docking and molecular dynamic...
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Posted by admin on Mar 31, 2024 in |
Plants have been the major source of drugs in Ayurveda and other ancient system in world. The Ayurveda, Siddha, Unani, Homeopathy systems have evidenced the use of plants for various disorders. Medicinal constituents from plants playa vital role in traditional as well as western medicine. Acalypha indica L. belongs to family Euphorbiaceae and is a common weed found in Asia, including India, Pakistan, Yemen, Srilanka and is well distributed in tropical areas of Africa and South America. Plant has emetic, expectorant, laxative and diuretic property, useful in bronchitis, pneumonia, pulmonary TB, Asthma, leaves are laxative, anti- parasiticide and possess antifungal activities. The plant possesses various pharmacological activities such as anti-inflammatory, antimicrobial, anti-ulcer, analgesic, anti- arthritic, HIV-1 reverse transcriptase inhibitory, antiurolithiatic, cytotoxic, anthelmintic, anticonvulsant, antianxiety, anti-malarial, lipid lowering, anti-venom and kidney protective activity. The present review gives a detailed survey of the literature on its phytochemistry, pharmacognosy, traditional uses and pharmacological...
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