Posted by admin on Feb 29, 2024 in |
Medication Adherence is defined as “the extent to which a person’s behavior in taking medication, lifestyle management, diet, corresponding with an agreed recommendation from a healthcare provider”. Hypertension also called high blood pressure is defined as persistency with an elevation in systolic blood pressure ≥140 mmHg and /or diastolic pressure ≥ 90 mmHg. A cross-sectional study was carried out in order to measure medication adherence, Morisky Green Levine-Medication Adherence Questionnaire developed by Donald Morisky was used to assess medication adherence assessment, which consists of 4 questions (items) whose wording questions are formulated to avoid answering ‘yes’ or ‘no’ and three levels of medication adherence: high, medium, and low were measured based on the scores 0, 1-2,3-4 respectively. The study carried out an evaluation of medication adherence among hypertensive patients. Among 245 respondents, 5.7% were found to be highly adherent, 37.6% were found to be medium adherent and 56.7% were found to be low adherent. A significant association between a family history of hypertension, diabetes, and smoking behavior was observed....
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Posted by admin on Feb 29, 2024 in |
C. splendens is a medicinal plant used for various ailments within the West-African Community. This study sought to investigate the pharmacognostic characteristics, mycobactericidal, and mutagenic activities of the hydro-ethanolic leaves extract C. splendens. The organoleptic, microscopic, macroscopic and physicochemical characteristics were investigated according to WHO, 2011 quality control methods for herbal materials. The mycobactericidal and mutagenic activities were investigated by the agar well diffusion assay and the Ames test (Muta-ChromoPlateTM) respectively. Present in C. splendens are tannins, flavonoids, glycosides, saponins, steroids and alkaloids which are comparable to published literature. The leaves of had anomocytic stomata, and starch granules, while calcium oxalate crystals were visibly absent. The 50% ethanol extract of C. splendens was not active against M. smegmatis at the highest concentration of 100 mg/mL. C. splendens was also non-mutagenic. Though the extract exhibited no mycobactericidal activity at the highest tested concentration, the documented pharmacognostic characteristics can be used for the purposes of authentication. Also, the non-mutagenic potential indicates a lack of toxicity in that...
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Posted by admin on Feb 29, 2024 in |
Trace elements are the dietary factors required by the body in small quantities for normal functioning of the body. The body’s functional skill is negatively impacted by a diet with insufficient trace elements, which lowers the body’s immune function. They are involved in catalyzing different enzymatic reactions. The permissible range of selenium is very narrow. Low levels of selenium have been reported in patients suffering from both acute and chronic kidney diseases. Reduced levels of selenium have also been reported in diabetic patients, while excess levels of selenium have been linked with inflammation and increased oxidative stress. Selenium at optimum amounts decreases oxidative stress by functioning as a cofactor of glutathione peroxidases and thioredoxin reductases. Insufficient intake of chromium leads to reduced insulin activity, hinder protein synthesis thereby leading to Type 2 diabetes mellitus. Chromium have been reported to boost enzyme activity and play crucial role in carbohydrate metabolism, increase sugar metabolism by initiation of insulin. This review aims to encompass the mechanism of action in prevention of diabetes...
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Posted by admin on Feb 29, 2024 in |
Aspartame is the most common artificial sweetener which is known to induce oxidative stress. Our goal was to determine whether Boeravinone B and Chebulinic acid protect HepG2 cells against Asp-induced oxidative stress in HepG2 on a multifarious level. In this investigation we have addressed ameliorative role of BB and CA in due course of Asp exposure by evaluating biochemical and molecular parameters. We found that Aspartame induced oxidative stress in HepG2 cells through elevation of ROS and RNS which was further attenuated by BB and CA. Associated levels of SOD, CAT, GPx, Protein carbonyls, Lipid peroxides and Caspase 3/7 in Asp treated cells were found to be risen but BB and CA supplementation restored these back to normal. It was revealed from fluorescence microscopy as well as flow cytometric analysis that BB and CA reversed the proportion of apoptotic, necrotic as well as autophagic cells which was found to be triggered during Asp exposure. mRNA expression of marker genes associated with Apoptosis, Necrosis and Autophagy was observed to be...
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Posted by admin on Feb 29, 2024 in |
Camellia sinensis has been used since several decades owing to its numerous health benefits. The purpose of this study is to investigate the developments in new varieties of Camellia sinensis. This new variety of tea possesses striking, purple-colored leaves, and hence, it is more commonly referred to as purple tea. This study analyzes the detailed mechanism of color change. An over-expression of genes in C. sinensis leads to an increase in the proportion of its anthocyanin content which is responsible for its color change. The genes accountable are CsAN1 (R2R3-MYB transcription factor), CsGL3 and CsEGL3 (bHLH transcription factor) and CsTTG1 (WD repeat protein). This feature stimulated us to review purple tea. The review article discusses its history, taxonomy, geography, process of cultivation and collection with the appropriate harvesting seasons, macroscopic and microscopic characteristics, and its extraction processes. The constituents obtained from Camellia sinensis and the chemical structures of its phytoconstituents were also discussed. The therapeutic properties like anti-diabetic, anti-allergic, anti-pyretic, anti-inflammatory, anti-oxidant anti-aging and anti-parasitic associated with C. sinensis...
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