Posted by admin on Feb 29, 2024 in |
Changes in drug prescribing-pattern in different groups of population and age-related pathophysiological changes may result in altered response of drugs and need proper monitoring to avoid adverse consequences. Polypharmacy is very common in elderly which further increases risk for unwanted effects. Moreover, physicians should be more familiar with the common problems and diseases occurring amongst elderly population and the drugs safe for this age group. Present study has been done to know the pattern of diseases occurring amongst elderly and commonly prescribed drugs for this population. Study-design was cross-sectional and it included private medical practitioners at Lucknow. Patients above 60 years of age attending these physicians were interviewed personally using a questionnaire. Thus, this study describes pattern of medication consumption by elderly patients among community dwelling in urban and rural areas of Lucknow. Out of 112 subjects interviewed, 51.5% elderly were prescribed three or more medications. Overall consumption varied from 1 to 10 different medications per day. Out of all medications prescribed; antihypertensives ranked first followed by analgesics, sedative-hypnotics,...
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Posted by admin on Feb 29, 2024 in |
The advancement of drug therapy has undoubtedly elevated patient care standards. However, it has also given rise to an increase in Drug-Related Problems (DRPs), which can significantly disrupt health outcomes. In an 18-month prospective observational study involving 2,000 patients, we meticulously assessed DRPs using the Hepler and Strand classification system. These DRPs encompassed a range of issues, including adverse drug reactions (ADRs), untreated medical indications, non-compliance with prescribed regimens, improper drug selection, and more. Our data collection adhered to a well-validated and pre-tested format. Among 2,000 patients, 106 (5.3%) experienced 117 DRPs, averaging 1.1 per patient. Adverse drug reactions (ADRs) accounted for 47.01% of cases, non-compliance 35.89%, and drug use without indication 11.32%. ADR incidence was 2.75%, primarily affecting the Gastrointestinal (GIT) system. Antibiotics were frequently associated with ADRs in various drug classes. Vigilant monitoring, robust reporting mechanisms, and patient education are pivotal strategies in the prevention of drug-related issues. Pharmacovigilance, the systematic monitoring and evaluation of drug safety and efficacy, plays a fundamental role in ensuring the delivery...
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Posted by admin on Feb 29, 2024 in |
The creation of reliable bioanalytical LC-MS (liquid chromatography-mass spectroscopy) methods is crucial for the discovery, development, and eventual marketing approval of new drugs. A brand-new medication called siponimod was developed to treat Multiple Sclerosis (MS). This medication is a sphingosine-1-phosphate (S1P) receptor modulator and is hypothesised to contribute to the reduction of MS-related inflammation of the central nervous system. Since the last several decades, the usage of ant sclerosis agents has grown dramatically, however there is currently no bio analytical approach available for quantifying siponimod in biological matrix investigations employing LC-MS/MS. To create a novel, quick, and accurate LC-MS/MS approach for simultaneously measuring siponimod in rat plasma utilising the liquid-liquid extraction method (LLE) and deuterated siponimod (SId6). Method: Chromatographic separation was performed in isocratic mode using acetonitrile and OPA buffer at a flow rate of 1 ml/min on a reverse phase Phenyl C18 (150 mm x 4.6 mm, 3.5 m) column. Utilising a positive-mode electrospray ion interface and multiple reaction monitoring (MRM) procedures, quantification was accomplished. Over the concentration...
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Posted by admin on Feb 29, 2024 in |
The plant Opilia celtidifolia, often known as ironwood or Opilia, is indigenous to many parts of Africa. It has a long history of traditional use in African herbal medicine, and its purported therapeutic benefits have attracted interest. An overview of Opilia celtidifolia’s cultivation, the portions used, and the identification of its chemical components are given in this abstract. The savannahs, dry woods, and semi-arid regions of African nations, including Nigeria, Ghana, and Senegal, are the main habitats for Opilia celtidifolia. Information on its controlled cultivation for therapeutic or commercial purposes is still scarce, nevertheless. Various parts of Opilia celtidifolia, including the leaves, roots, stem bark, and seeds, have been traditionally employed for medicinal purposes. Each part serves specific therapeutic applications, such as the use of roots for wound healing and leaves for various conditions. Opilia celtidifolia contains a diverse array of chemical constituents, including alkaloids, flavonoids, polyphenols, and other bioactive compounds. Opilia celtidifolia is a plant with a rich history in African traditional medicine. It is believed to possess...
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Posted by admin on Feb 29, 2024 in |
Rheumatoid arthritis (RA) is a chronic progressive inflammatory autoimmune ailment with multifactorial etiology. The human gut is a massive intricate ecosystem where microbiota, nutrients, and host cells interact extensively to uphold gut homeostasis. Gut microbiota acts as a modulator of immunity and dysbiosis has detrimental effects on health by triggering a persistent inflammatory response that may eventually result in disease. Probiotics are live microorganisms that can normalize gut microbiota and boost the host’s health when administered in adequate amounts. Recent research has demonstrated that probiotics have important roles in the makeup of the gut microbiota, which can prevent pathogenic bacteria from colonizing the intestine, support the host in developing a strong intestinal mucosa defensive barrier, and reinforce the host immune system. Probiotics have positive effects on health, including immune system regulation and anti-inflammatory activity by preventing the release of pro-inflammatory cytokines like TNF-. Probiotics may affect NF-kB, proteasome activity, Toll-like receptors, as well as their regulators and stimuli, at various sites along the MAPK pathway. Because of the close...
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