Posted by admin on Feb 29, 2024 in |
The Cu-Atropine complex may have potential applications in medicinal chemistry, as atropine is used in the treatment of certain medical conditions such as bradycardia and as a pre-anesthetic to decrease salivation. Additionally, the complexation of atropine with copper could potentially enhance its therapeutic effects or alter its pharmacokinetic properties. In the present study, the drug has been modified by complex formation with absolute methanol and concentrated sulphuric acid following standard procedures to increase its potency. IR spectra of Cu- atropine complex has taken. The analytical data indicates that a complex form of the drug, Cu-Atropine, is formed in a 1:1 ratio. To study the interaction between drugs and metal complexes, differential pulse polarography (DPP) has been used. These techniques are simple and cost-effective, making them suitable for qualitative and quantitative determination of active drug compounds. In a pharmacological study, modified atropine showed more potency compared to its parent...
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Posted by admin on Feb 29, 2024 in |
The Indian medicinal plant Boswellia serrata, sometimes known as frankincense in the West, has been used in traditional medicine to heal burns and wounds. The objective of this study was to investigate the capability of B. serrata (Boswegex®) to enhance wound healing by carrying out an in-vitro scratch experiment on human dermal fibroblast cells (HDF). Povidone-Iodine 5% cream was used as a positive control to determine the efficacy of Boswegex®‘s wound healing activity. The cytotoxicity, along with proliferation and migration activities, were evaluated against the human dermal fibroblast cell line HDF using the MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium] assay. Interestingly, Boswegex® was found to stimulate proliferation and migration of HDF cells at given concentrations and enhance the closure rate of the wound area within 24 hours after treatment. Boswegex® was evaluated for its cytotoxicity at different concentrations ranging from 1000 µg/ml to 0.975 µg/ml, which resulted in 7.78±0.06 µg/ml and hence the concentrations of 2µg/ml and 1µg/ml. In the scratch assay, 349.62µM and 234.8 µM migrations of cells were exhibited...
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Posted by admin on Feb 29, 2024 in |
The objective of the research was to compare the efficacy and safety of Olanzapine versus Risperidone as an add-on to Lithium carbonate in patients with bipolar affective disorder. Methods: Prospective, randomized, comparative study conducted in psychiatric Department from Nov 2018 to May 2020. 80 BPAD patients who fulfilled eligibility criteria were randomized (1:1) into two groups of 40 each receiving Olanzapine with Lithium (Group A) or Risperidone with Lithium (Group B) for 12 weeks. Efficacy was measured by reduction in Young Mania Rating Scale (YMRS) score and Hamilton Depression Rating Scale (HAM-D) score at 6th and 12th week. Safety was assessed by monitoring treatment emergent adverse effect. Data analysed using repeated measure ANOVA, Mixed ANOVA, chi-square and descriptive statistics. Results: Olanzapine and Risperidone treated BPAD patients showed significant reduction in YMRS score from baseline to 12th week (p<0.001) but there was no statistically significant interaction between time and groups (p=0.71). Significant reduction in HAM-D score from baseline to 12th week was observed in both Olanzapine and Risperidone group (p<0.001)...
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Posted by admin on Feb 29, 2024 in |
Rheumatoid arthritis is an autoimmune and inflammatory disease, in which immune system attacks healthy cells in your body by mistake, causing inflammation (painful swelling) in the affected parts of the body. Aceclofenac is a phenyl acetic acid derivative and NSAID with anti-inflammatory, analgesic and antipyretic effects. Nanosponges were prepared by the Emulsion solvent diffusion method with varying concentrations of Ethyl cellulose and Poly vinyl alcohol. FTIR and DSC study reports confirmed the absence of incompatibilities between the drug and the excipients. Nine Nanosponge formulations were prepared (F1- F9) and evaluated for particle size, PDI, Production yield, entrapment efficiency, Zeta potential, SEM analysis, in-vitro drug release and kinetic studies. The kinetic data analysis of Nanosponges fit to Higuchi model and follows Zero order kinetics. All the Nanosponge formulations were incorporated into 1% Carbopol gel base to produce drug loaded Nanosponge gel. The drug-loaded Nanosponge gel was evaluated for physical properties, pH, Viscosity, Spreadability, Extrudability, Drug content and in-vitro drug release, in-vitro anti-inflammatory activity, ex-vivo permeation study, kinetic study and stability...
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Posted by admin on Feb 29, 2024 in |
Organic chemist has developed the number of heterocyclic compounds. The heterocyclic compounds have gained more attention in medicinal and organic chemistry because of their numerous biological activities. There are various types of the heterocyclic compound available for several biological activities such as antibacterial activity, anticancer activity, antiepileptic activity, antipsychotic activity, antihypertensive activity, antiproliferative activity. Pyrrole, furan, benzimidazole, thiophenol, thiophene, imidazole and indole compounds became more popular heterocyclic compound due to their biological activities, beta- lactam ring system has important role in the design of different antibiotics as well as in the biological activities. Furthermore the recent advancement that occurred in the scheme of heterocyclic compound caught more attention in many product developments. The present review article focused on the heterocyclic compound, classification, nomenclature, importance of heterocyclic compound, history of heterocyclic compound and recent development in the scheme along with their biological...
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