Posted by admin on Nov 30, 2024 in |
The chick was chosen as a model because it is more readily available than rats or mice and its organogenesis is analogous to that of humans. Rolapitant is a highly potent, powerful antagonist of the neurokinin-1 receptor, featuring a high degree of infiltration to the brain. The study aimed to assess the morphological and histopathological analysis of the brain (cerebral cortex) of growing chick embryos in response to the rolapitant’s effect. Three hundred fertilised white leghorn chicken eggs were utilised, separated into five control groups (C1 to C5) and five experimental groups (E1 to E5), each with thirty eggs. On the fifth day of incubation, eggs from five experimental groups were exposed to different concentrations of rolapitant at 0.00039 mg, 0.0005 mg, 0.00075 mg, 0.001 mg, and 0.00125 mg respectively, whilst five control groups received the same concentration of normal saline. Chick brains were obtained and weighed. The cerebral cortex (brain) was sectioned and stained to examine the histopathological abnormalities. A significant growth retardation and decreased weight of the...
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Posted by admin on Nov 30, 2024 in |
Isatin is magical molecule widely used in drug discovery of many areas like anticancer, anti-inflammatory, antiviral, anti-convulsant, anti-tubercular, antimicrobial, antidiabetic most important it was found effective in COVID-19 as well as on Lumpy Skin Diseases. Isatin can be synthesized by different methods like Sandmeyer method, Gassman synthesis. Isatin was modified by researchers at C2, C3, C5, position and contribute its magic into the medicinal field. In this research article, main focus has been done on design and docking of various derivatives possessing promising biological activity, novel drug design strategies and their respective drug target. It will provides different approaches to design new drug entity along with docking studies to the young researcher to dig new aspect of...
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Posted by admin on Nov 30, 2024 in |
In the 21st century, human lifestyle has been faster than previous. People of this generation require faster results of each and everything which leads to change in lifestyle. Due to this immediatism invention of rapid release dosage forms are immerging in pharmaceutical market, from which Oral wafer is one of the dosage forms which provides rapid release of the drug. These oral wafers can be administered by oro-mucosal route which can be on the tongue, sublingually or buccal route. It disintegrates in saliva within 14 seconds and dissolution of 99% of drug in saliva has obtained within 60 seconds. There was total three challenges in this research. The antibiotic used in this research was BCS class II drug which leads to poor water solubility which may hamper the rapid action. Extremely bitter taste of drug was the second challenge and Incorporation of high dose in oral wafer was the third challenge. These all challenges have been conquered in this...
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Posted by admin on Oct 31, 2024 in |
Avocado (Persea americana) seeds are an excellent source of antioxidants, and phenolic compounds were used to create green synthesis nanoparticles that were then incorporated into formulations for solid herbal tablets. The process of ionic gelation is used to synthesize biopolymer chitosan nanoparticles. The characterization was done by UV and FTIR spectroscopy. FTIR spectroscopy showed that chitosan nanoparticles included many functional groups. Pre- and post-compression experiments were conducted on a herbal tablet formulation made using the direct compression method. Biological activities like antidiabetics, antioxidant, anti-inflammatory, anti-bacterial and anti-fungal studies were carried out using in-vitro method. Anti-diabetic activity resulted in an appreciable percentage inhibition of α-Amylase (99.82%), which is comparable with the standard metformin (86.05%). Antioxidant activity measured using DPPH method demonstrated the scavenging activity of herbal formulations (67.98%) and nanoparticles (58%), surpassing standard ascorbic acid (18%). The herbal formulation exhibited the largest percentage inhibition of anti-inflammatory action (77.79%) as determined by the human red blood cell membrane stabilization technique, and nanoparticles (70.38%) exceeding standard drug diclofenac (43.7%). The tablets that...
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Posted by admin on Oct 31, 2024 in |
Background: Drug-related problems are an ongoing, potentially harmful event that can affect the health of an individual. Various underlying health conditions and multiple drug uses are some of the factors contributing to drug-related problems (DRPs). This study aimed to determineDRPs in common chronic neurological conditions and intervention by clinical pharmacist in a tertiary care hospital, India. Methods: In this prospective study, the data of hospitalised neurological patients during December 2022–February 2023 were enrolled. Electronic medical databases and patient medical charts were used as data sources. Baseline characteristics were correlated with DRPs using Cramer’s V correlation. The DRPs were classified using Pharmaceutical Care Network Europe (PCNE) Version 9.1. Results: A total of 300 patients were enrolled, in which the majority 83% had drug-related problems. The incidence of drug-related problems was found to be 0.27 cases per person per month. The most identified drug-related problem was found in the domain of treatment effectiveness, and the most identified cause belonged to the subdomain of drug use process. Most of the interventions proposed...
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