Posted by admin on Jan 31, 2024 in |
Various bioactive aromatic compounds containing the indole nucleus showed clinical and biological applications. It has the unique property of mimicking different structures of proteins and binding to enzymes in a reversible manner. Indole scaffold has been found in many of the important synthetic drug molecules which gave a valuable idea for treatment and binds with high affinity to the multiple receptors helpful in developing new useful derivatives. Indole derivatives possess various biological activities, i.e., antiviral, antifungal, antidiabetic, anti-inflammatory, anticancer, antifertility, anti-HIV, antioxidant, antimicrobial, antitubercular, anticonvulsant, antimalarial, anticholinesterase activities, etc. which created interest among researchers to synthesize a variety of indole derivatives. This review focussed on recent developments of indole derivatives having different pharmacological profiles as well as different perspectives on how this indole moiety as a privileged structure may be exploited in the...
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Posted by admin on Jan 31, 2024 in |
This study aims to evaluate the impact of a personalized DASH diet and lifestyle modifications on blood pressure levels in individuals diagnosed with stage-1 hypertension. An observational study with purposive sampling was carried out over one-year duration, specifically from April 2022 to March 2023. Data was gathered through a self-structured interview schedule questionnaire and subjected to descriptive statistical analysis. The study subjects were provided with interventions targeting lifestyle modifications and implementation of a customized DASH diet. Post-intervention changes were recorded during the follow-up 2. The paired t-test was employed to determine the significant differences in systolic and diastolic blood pressure. A total of 300 individuals diagnosed with stage-1 hypertension participated in the study, with a mean age of 47.19 (SD: 12.68). The study population consisted of 63% females (n=189) and 37% males (n=111). Results of the study revealed a significant decrease in both systolic (P<0.001) and diastolic (P<0.001) blood pressure levels among the participants who underwent a customized DASH diet and incorporated lifestyle changes into their daily routines. Furthermore,...
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Posted by admin on Jan 31, 2024 in |
The present research aims to develop a transdermal Cubosomal gel formulation of Indomethacin, which would attenuate the gastrointestinal toxicities associated with oral administration and also aimed to encapsulate high drug pay load in Cubosomes for improved therapeutic efficiency. Indomethacin is an NSAID commonly recommended for the relief of pain and inflammation. Indomethacin was formulated as Cubosome to avoid the gastric irritaion. Top- down techniques were used for the preparation of cubosomes. Different formulations (F1-F6) were prepared and optimized for better performance in terms of drug content, SEM analysis, Zeta potential, entrapment efficiency and drug release. Then it is formulated into gel using carbopol as gel base. The physical parameters like appearance, pH, viscosity, spreadability, extrudability, ex-vivo drug release and in-vitro skin irritation test using HET- CAM were also evaluated. The cubosomal gel formulation (F5) was found to be clear without any aggregate indicating excellent homogeneity. The ex-vivo drug release study shows that the formulation (F5) has a good release rate. The kinetic study of the optimized formulation (F5) was...
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Posted by admin on Jan 31, 2024 in |
Traditional medicine has been aware about and made use of “medicinal herbs,” for millennia. Numerous chemical compounds are produced by plants to serve a variety of purposes, including defence and protection against diseases and disorders. Type 1 diabetes mellitus (T1DM) and Type 2 diabetes mellitus (T2DM) are prevalent forms of DM, characterised by deficient insulin secretion (in T1DM) or impaired insulin action (in T2DM). Type 1 diabetes mellitus (T1DM) is typically identified in the paediatric and adolescent population, whereas type 2 diabetes mellitus (T2DM) is more prevalent among middle-aged and elderly individuals. The latter group often exhibits chronically elevated blood glucose levels due to lifestyle and dietary choices that are deemed detrimental to health. The black plum, or Eugenia jambolana Lam. (syn) Syzigium cumini (L.) skeels, is a medicinal plant widely used in various alternative Indian medical systems such as Ayurveda, Unani, and Homoeopathy. The utilisation of this plant has demonstrated efficacy in managing diabetes mellitus, mitigating inflammation, healing ulcers, and alleviating symptoms of diarrhoea. Preclinical studies have demonstrated...
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Posted by admin on Jan 31, 2024 in |
Background: Betel nut and different variants of tobacco and smoking is hazardous causing oral and or pharyngeal squamous cell carcinomas (SCC). In Assam, “Tamol”, a raw, unprocessed betel nut is mixed with lime and betel leafis an alarming factor for oral and oropharyngeal SCC. Aim: To assess the patterns of tobacco, betel nuts and smoking causing variations in morphological differentiation of oral and oropharyngeal SCC. Methods: Morphological variations of 40 oral and oropharyngeal SCC’s were studied. A self answered predesigned questionnaire was used regarding the patterns and years of abuse of tobacco, betel nuts and smoking. Results: 90% of cases show tobacco prevalence, 90% show betel nut prevalence in the form of raw betel nut (58.3%), dried betel nut (27.8%) and betel nut in the form of panmasala/gutkha (13.9%). 50 % show smoking prevalence in the form of beed is (80%), cigarettes (10%) and weeds (10%) respectively. Among 22 cases of well differentiated SCC, 86.3%, 90.9% and 36.3% consumed tobacco, betel nuts and smoke respectively for at least 10...
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