Posted by admin on Jan 31, 2024 in |
Oral administration is the preferred route of drug administration owing to its convenience, patient compliance, and cost-effectiveness. The study aspired to augment the solubility and dissolution rate of Rosuvastatin calcium (RST) by using the solid dispersion (SD) technique with various generations of hydrophilic polymers. Hot melt and solvent evaporation methods were employed to prepare SD using various hydrophilic carriers such as Urea, PEG-6000, Poloxamer-F127 and β-cyclodextrin (β-CD). The prepared SD was evaluated and the optimized formulation was subjected to tablet formulation by direct compression method and a quality control test was performed. After screening all the hydrophilic polymers, SD was prepared by using β-CD shows a remarkable increase in solubility and dissolution. Among the ratios 1:1, 1:5 and 1:7, SD with 1:5 showed increased solubility and maximum drug release and shows good surface characteristics were identified by SEM analysis. Finally, the prepared core tablet CF2 was found to have better dissolution efficiency of 96.34% drug release at 60mins, when compared with CF1 (81.46%) and the Marketed tablet (85.44%). The...
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Posted by admin on Jan 31, 2024 in |
Now a day’s food materials are packaged and wrapped in paper that is the dangerous practice of wrapping, covering or processing foods with newspaper and printed recycled paper materials remains commonplace worldwide, as seen in the plethora of photographs in advertisements online or in magazines showing newspaper wrapped foods. The health hazard of ink contamination to foods and long-term contact with complex chemicals should always be considered because of the potentially diverse array of biological and toxicological effects. Polycyclic aromatic hydrocarbons inhibit the function of thyroid, adrenal and male reproductive system, like secreted hormonal imbalance due to this several disorders occurs in human body. However, proposed studies will be helpful to human health especially to thyroid, adrenal and male reproductive system deficiency caused by polycyclic aromatic hydrocarbons because we have avoided ink-based newspaper wrapped food materials to minimize the endocrine glands diseases. We will initiate systematic campaigns for generating awareness among all the stakeholders to discourage the use of newspapers for packing, serving and storing food items. Therefore, this...
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Posted by admin on Jan 31, 2024 in |
Cannabis sativa L. is an annual herbal plant of the family Cannabinaceae and abundant in nature. It is known locally as igbo, taba, blaze, joint, pot, dope, ganja, sensi, kpoli, weed, and morocco on the streets of Nigeria, and used as a medicinal plant for many centuries in many different parts of the world. Although native to Central Asia, Cannabis is now grown globally. Cannabis is the most abused plant worldwide, used for medical and recreational purposes. Recent studies have shown its efficacy in several disease conditions, including pain, sleeplessness, depression, and intractable epilepsy. The use, handling and cultivation of Cannabis sativa in Nigeria is illegal and backed by several laws. Despite the availability of these regulations and legislation, Nigeria is currently dealing with a drug abuse issue. After alcohol, cannabis is the most often used illicit/illegal substance in Nigeria, with a 10.8% estimated prevalence use rate. Cannabis use in Nigeria has no class distinction as it is used by both the rich and the poor, with Nigeria currently...
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Posted by admin on Jan 31, 2024 in |
Background: Melasma is a frequent hyper pigmentary disorder characterized by the presence of brown to grey patches on the face. For melasma management, various modalities available that includes kojic acid, azelaic acid, Kligman’s regimen, peels like glycolic acid, trichloroacetic acid (TCA), jessner’s etc are in use but unsatisfactory results, recently tranexamic acid (TA) has added to treatment armamentarium for resistant melasma. Objective: To know the efficacy of oral tranexamic acid with glycolic acid 35% peel verses oral tranexamic acid with modified jessner’s peel in treating melasma. Materials and Methods: Present study includes 60 patients with melasma, divided into group A and group B. Group A treated with glycolic acid peel and oral TA and group B treated with modified jessners peel with oral TA. Severity of melasma was assessed after 4th, 8th and 12th weeks after combination treatment using mMASI score. Results: Present study mean age affected 43.2+/-5.4 years, predominantly affected were females (75%). There is a significant difference in the severity of melasma between both groups at the...
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Posted by admin on Jan 31, 2024 in |
The population is currently under threat from a new global health emergency called COVID-19 (Coronavirus Disease-2019). The World Health Organization has classified the virus epidemic as a public health emergency of international concern since December 2019, when COVID-19 first surfaced at a seafood market in Wuhan, South China, and spread quickly throughout the world (WHO). In order to inform potential COVID-19 patients about COVID-19 prevention, diagnosis, treatments, and prevention, we have summarized the most recent clinical characteristic data below. We gathered information for this evaluation from a number of research reports, WHO recommendations, and other articles. It is crucial to remind readers that new information on clinical traits, diagnoses, treatment plans, and outcomes for COVID-19 is updated almost hourly. The ailment has affected people to varied degrees all across the world. The patient displays a variety of symptoms, most frequently a fever, cough, sore throat, shortness of breath, exhaustion and malaise. The condition is treated with general care, symptomatic care, antiviral medication, oxygen therapy and the immune system. To...
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