Posted by admin on Dec 31, 2023 in |
Pharmacological research is a complex and challenging field that seeks to understand the effects of drugs on living organisms. In-vivo and ex-vivo methods are two of the most essential tools used in pharmacological research, each with its own advantages and disadvantages. In-vivo methods involve testing drugs in living organisms, typically animals. This type of research can provide valuable information about the effects of drugs on the entire organism, including its metabolism, distribution, and elimination. However, in-vivo research can be expensive, time-consuming, and ethically challenging. Ex-vivo methods involve testing drugs on isolated tissues or cells. This type of research can provide more detailed information about the mechanisms of action of drugs, but it needs to consider the drug’s effects on the entire organism. The use of in-vivo and Ex-vivo methods together can provide a complete understanding of the effects of drugs. In-vivo methods can be used to identify potential new drugs, while ex-vivo methods can be used to study the mechanisms of action of drugs and to optimize their dosage...
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Posted by admin on Dec 31, 2023 in |
The flavonoid compound quercetin is widely acknowledged for its diverse biological properties including anti-inflammatory, antioxidant, anti-bacterial, anti-ageing, anticancer however the constraints like poor solubility, low bioavailability, lack of stability and decreased permeability limits its pharmacological applications. Hydrogel assisted delivery systems especially for transdermal delivery of phytochemicals like quercetin is being suggested but least explored for its efficacy as an anti-inflammatory system. A PVA – alginate system was synthesized with quercetin and was explored for its effect as a potent anti-inflammatory system. The synthesized hydrogel was found to exhibit 56% loading efficiency and shown a sustained release over time as determined using HPLC analysis. The hydrogel system exhibited appreciable inhibition of total COX, 5 LOX, iNOS activity, Nitrate levels and MPO activity in RAW macrophage cells when compared with LPS alone treated groups affirming anti-inflammatory potential which can find applications in development of therapeutic regimens which will emphasize an economical, highly effective and risk-free plant drug with minimum side...
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Posted by admin on Dec 31, 2023 in |
The present study evaluated the Anthelmintic activity of Ficus benghalensis bark extract against Indian earthworm Pheretima posthuma and compared it with the standard drug Albendazole. The results showed that the extract exhibited significant Anthelmintic activity, as evidenced by the time of paralysis and time of death of worms. The extract also contained various phytochemical constituents, including Phenolics, Terpenoids and Miscellaneous constituents. The findings of this study suggest that Ficus benghalensis bark extract may be a potential natural Anthelmintic agent. This activity was concentration dependent. As the concentration increases the extract produce maximal effect. Higher concentrations of ethanolic bark extract of Ficus benghalensis produce a paralytic effect much earlier and time taken for death was shorter. It shows maximum efficacy at 75 mg/ml concentration than the standard drug. Further studies are recommended to isolate and identify the active principles responsible for its activity. This could lead to the development of new drugs for the treatment of worm infections. The study provides valuable information on the medicinal properties of Ficus benghalensis...
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Posted by admin on Dec 31, 2023 in |
The herbal drugs derived from plant sources are used in traditional pharmacopeia and also act as precursor in lab to synthesize medicines at large scale. Acanthaceae is a large family comprising of various medicinally valuable species. In traditional use, the leaves of this family are commonly recognized to alleviate the poisonous bites of reptiles and insects and whole plants for the treatment of external wounds and ulcers. The pharmacological effects evaluated from various species of this family are antibacterial, antifungal, antipyretic, hepatoprotective, anti-inflammatory, cytotoxic, antioxidant, anti-platelet aggression and insecticidal activities. The phytochemicals reported from this family are mainly flavonoids, alkaloids, lignans, benzonoids, fatty acids, terpenoids, tannins and a few triterpenoid saponins. In the present study two genera namely Blepharis and Lepidagathis of the family Acanthaceae were selected with the focus on their traditional use, chemical constituents, and pharmacological activities. Various pharmacological experiments have verified their practice in traditional use and species of both the genera emerged as good source of herbal medicines. However, uncharacterized crude extract was employed in...
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Posted by admin on Dec 31, 2023 in |
Introduction: Urolithiasis is one of the most common urologic diseases worldwide, with an estimated prevalence ranging from 1% to 13% across the globe. It’s increasing prevalence can be attributed to the westernization of lifestyle habits. The homoeopathic system of medicine offers a positive scope in the management of urolithiasis with hyperuricemia, prevent to undergo in surgical interventions and also prevents recurrence. Case Summary: The presented case involved a patient experiencing continuous severe pain in the right renal region for the past ten days, along with elevated uric acid levels. Bryophyllum pinnatum mother tincture was prescribed based on the acute presentation, followed by Lycopodium clavatum considering the chronic totality. This treatment approach resulted in a significant improvement in the patient’s presenting complaints. Objectively, the treatment led to a gradual decrease in serum uric acid levels, elimination the kidney calculus as observed in ultrasonography and reduced propensity for recurrent renal calculus formation. Additionally, the liver’s echo texture remained normal throughout the treatment. The modified Naranjo Criteria score (MONARCH) post treatment was...
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