Posted by admin on Dec 31, 2023 in |
Biopharmaceutical technologies used to create biodegradable materials from biological agents fall within a broad spectrum. The production of bioproducts has grown cleaner and more dependable with the adoption of novel biotechnological approaches. The original study objective was to investigate the legal difficulties surrounding the purchase and sale of biological as well as pharmaceutical products. The production, advancement, and application of biosimilars in medical care are all governed by a legal regime. Guidelines are collections of requirements that producers must adhere to guarantee the efficacy and effectiveness of pharmaceuticals as well as the highest possible consumer security against newly produced goods. Control of biopharmaceuticals entails a comprehensive strategic plan to guarantee superior levels of security and performance. The research concentrates mainly on the trade in and out of drugs from Switzerland, Brazil, and India. International drug manufacturers are now given a stronger legal base on which to introduce novel drugs to the marketplace. This licensing process for new pharmaceuticals can take a year or longer because the healthcare regulatory structure...
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Posted by admin on Dec 31, 2023 in |
Cerium oxide nanoparticles, also known as Nanoceria, have attracted a lot of attention due to their remarkable catalytic activities, which result from a rapid and efficient modification of the oxidized state between Ce4+ and Ce3+. The cerium atom may quickly and dramatically change its electrical arrangement to better suit its immediate surroundings. It also has oxygen vacancies, or flaws, in the lattice structure, which result from the loss of oxygen and/or its electrons during redox processes, alternating between CeO2 and CeO2 x. Being a mature engineered nanoparticle with a variety of industrial applications, it was recently discovered to have multi-enzyme, including reactive oxygen species oxidase, catalase, and oxidase, mimetic properties that produce a variety of biological effects, including being potentially anti – oxidants towards almost all toxic and harmful intracellular reactive oxygen species. In biological domains such as bioanalysis, biomedicine, drug carriers, and bioscaffolding, nanoceria has emerged as an intriguing and valuable material. This review paper gives a thorough overview to nanoceria nanoparticles and their manufacture, multi-enzyme-like activity, prospective...
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Posted by admin on Dec 31, 2023 in |
Background: Sodium fluoride (NaF) is an inorganic fluoride salt used for the treatment of dental caries topically. It is also used in water fluoridation to prevent tooth decay. It has been reported to be associated with a lot of harmful effects, including neurotoxic effects. The aim of our study was to evaluate the chronic effects of NaF on the models of cognition in adult mice. Methods: Forty mice were randomly divided into four equal groups. NaF was administered dissolved in drinking water. The control group was Group I and received distilled water. Oral NaF at doses of 10mg/L, 20mg/L and 30mg/L respectively was given to Group II, Group III, Group IV. The influence of fluoride exposure on cognition was assessed using forced alternation test and spontaneous alternation test using Y-Maze. Evaluation was done at baseline, at the end of one month, two months and three months of NaF administration. Statistical analysis was done with the help of the Wilcoxon Signed Rank Test (within the group), Kruskal Wallis Test (between-group)...
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Posted by admin on Dec 31, 2023 in |
The bio-active compounds present in Terminalia arjuna (Roxb. ExDC) have anti-oxidant, anti-proliferative, anti-obesity, anti-hyperglycemic, and lipid-lowering activity. In addition, it has cardioprotective, hepatoprotective, and renoprotective properties. The study evaluated in-vivo toxicity profile of the methanolic extract of Terminalia arjuna (META) bark on male albino Wistar rats before undertaking further investigation on the use of this extract as a potential therapeutic agent against such conditions. Animals were administered with 300 and 2000 mg/Kg b.w./day of META bark for 14 days; and 250, 500, and 1000 mg/Kg b.w./day of META bark for 28 days for acute and sub-acute toxicity respectively. The outcome of the acute toxicity study revealed no signs of mortality or general behavioral alteration in treatment groups in comparison to the control group. The sub-acute toxicity study revealed, there is no significant influence (p<0.05) of META bark in food consumption and percentage weight gain in the animals. No significant changes (p<0.05) in hematological parameters as well as in biochemical parameters were observed. Histopathological examination showed normal cellular architecture of...
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Posted by admin on Dec 31, 2023 in |
A quick and affordable analytical method validation for the determination of Ascomycin content in Tacrolimus API by HPLC UV-detector was developed with respect to the accuracy, precision, linearity, selectivity, robustness, limit of quantification, limit of detection, according to ICH guidelines. The extraction of samples was performed using HPLC –LC Solutions Chemstation system manufactured by WATERS by using X-TERRA, C18 (4.6 x 150mm, 3.0μm) in the Presence of mobile phases A&B composed of 6 ml orthophosphoric acid and Acetonitrile: Tert-butyl Methyl Ether (81:19) in the ratio of 4: 1 and 1: 4. The estimated samples were then analysed using an UV visible code 2487 manufactured by Waters. With a linear calibration curve spanning from the mean recovery of method precision and system precision 140765 and 142973 and %of relative standard density is found to be 0.30% and 0.87%. With retention time of Ascomycin 29.5mins and Tacrolimus 33.4 min. Column oven temperature of 60 0C at a flow rate of 1.5mL/min and wavelength is found at 220 nm the total run...
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