Posted by admin on Dec 31, 2023 in |
Dry eye disease (DED) is one of the most common conditions in today’s digitalized society. DED is associated with decreased tear production, an unstable tear film, and ocular inflammation. Due to the COVID-19 pandemic, the use of digital screens (computers, laptops or smartphones) for work, study or entertainment has increased. As a result, the constant use of digital screens affects the eyes and makes everyone, including youth in the modern era, more susceptible to dry eye disease (DED). Alterations in mucin production are considered one of the most important causes contributing to dry eye disease. MUC5AC, a gel-forming mucin, acts as a surface active agent on the ocular surface and facilitates an evenly distributed tear film that moisturizes the conjunctival epithelium. The prolonged use of artificial tears and other allopathic medications results in specific adverse effects. Therefore, dietary nutrient intake and nutraceutical supplementation with active ingredients can be considered a safe and effective therapy for the treatment of dry eye disease. In conclusion, this review focused on some nutrients...
Read More
Posted by admin on Dec 31, 2023 in |
Objective: The present study was designed for the synthesis, characterization, biological evaluation, and MTT assay of some novel thiadiazole derivatives as anti-tubercular agents targeting decaprenylphosphoryl beta-d-ribose2’ epimerase-1(DPRE1). Methods: The molecular docking study for titled compounds was performed from Autodock 4.2. Software http://autodock.scripps.edu/, pdb file was generated by chem3D.pro software tool. The binding pose for the significant compounds was visualized by Biovia, the Discovery studio visualizer. The selected molecules were synthesized and recrystallized several times to reach the expected purity. All the purified compounds were characterized by various spectral analytical techniques and evaluated for anti-mycobacterial activity against tuberculosis H37RV strain by Microplate Alamar Blue Assay (MABA) method and cell line studies. Results: The experimental results showed that the Compounds SDK3 and SDK5 have an anti-tubercular activity in the Concentration of 3.12µg/mL. Cell line studies for proprietary compounds have been carried out by MTT assay using HEK (Human embryonic kidney cells) method. It also correlated with the highest docking score. Conclusion: The development of the SDK3 and SDK5 structures will produce...
Read More
Posted by admin on Dec 31, 2023 in |
Millions of people throughout the world suffer with epilepsy, a neurological illness that frequently results in seizures. Epilepsy has been treated using both allopathic and ayurvedic medicinal methods. Antiepileptic medications (AEDs) are used by allopathic medicine, commonly referred to as contemporary medicine, to manage seizures. Several AEDs have been created recently in allopathic medicine, such as Brivaracetam and Perampanel, which have better effectiveness and safety than earlier AEDs. Background: Approximately 1% of the global population suffers from epilepsy, a neurological illness marked by recurring seizures. Epilepsy is a difficult condition to manage despite improvements in medical technology, with up to 30% of patients still experiencing seizures while receiving antiepileptic medication (AEDs). Conclusion: Epilepsy is increasingly being treated with both allopathic and ayurvedic therapy. There are several ongoing clinical trials for the treatment of epilepsy using both allopathic and ayurvedic drugs. Because it is more practical for their busy lifestyles, has a quick mechanism of action, and is readily accessible, allopathy therapy is preferred by many...
Read More
Posted by admin on Dec 31, 2023 in |
Triphala churna is a poly-herbal preparation that has anantiquity of usage in the conventional Indian medical system. It is rich in antioxidants and has excellent therapeutic efficacy. According to ayurveda, the churna is made using the raw ingredients Amalaki (Indian Gooseberry), Haritaki (Indian Hog Plum), and Bibhitaki (Vibheetaki) in an equal proportion (1:1:1). The present investigation purpose was to establish the Triphala’s antimicrobial effect on different types of bacterial stains and its antioxidant effects. Numerous cross checks examinations have been conducted, such as phytochemical detection, physico-chemical analysis, pharmaceutical analysis, to evaluate herbs’ quality attributes, including formulations’ assurance and effectiveness. A comparison of the antioxidant and antibacterial capabilities of polyherbal drug’s aqueous and ethanolic extract follows. Antioxidant activity of Triphala churna was established by FRAP assay and 2,2-diphenyl-1-picrylhydrazyl free radical scavenging methods. By using broth dilution, antibacterial potential was assessed. Triphala reported the presence of valuable bioactive components, including phenols, alkaloids, and flavonoids, which may be in charge of certain biochemical activities, was found, according to the results. Ascorbic acid-like...
Read More
Posted by admin on Dec 31, 2023 in |
Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that affects the major oil gland-containing areas, such as the face, back, and trunk. It involves increased sebum production and hair follicles abnormally desquamate as a result of rising androgen levels that coincide with puberty. It is generally characterized by, the formation of seborrhea, comedones, inflammatory papules, pastures, nodules, and lesions. Propionibacterium acnes and Staphylococcus epidermidis have been identified as bacteria that cause acne inflammation by generating pus. Staphylococcus aureus contributes to causing inflammation in acne. Herbal formulations have growing demand in the world market So, the current research focuses on developing and assessing a herbal face wash against the acne vulgaris and its etiologic agent. The ethanolic extract of Turmeric (rhizomes), Neem (leaves), Black pepper (fruit) and Nutmeg (fruit) was prepared by using a maceration process and formulated into a topical gel. The plants have been used in the formulation the having good anti-microbial, anti-oxidant and anti-inflammatory activity. The gel was formulated with different concentrations of the...
Read More
