Posted by admin on Jan 31, 2017 in |
The extracts of Spinacia oleracia leaves studied for Phytochemical screening and different extract of Spinacia oleracea leaves was studied for immunomodulatory activity. The immunomodulatory effect was evaluated by delayed type hypersensitivity response using SRBCs. The n-hexane, dichloromethane, methanolic and aqueous extract of Spinacia oleracea leaves was studies for DTH response. The dichloromethane extract of Spinacia oleracea leaves extract showed significant increase in the hypersensitivity response, indicating its effect on cell mediated immunity. From the above result, it was concluded that the preliminary Phytochemical analysis revealed that different active constituent present in different extracts such as carbohydrates, proteins, amino acids, fat, oils, steroids, terpenoids, glycosides, alkaloids, tannins and other phenolics compounds and the dichloromethane extract of Spinacia oleracea has a significant effect on cell mediated...
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Posted by admin on Jan 31, 2017 in |
An HPLC method was developed with the aim of quantifying the levels of Methyl Vinyl Ketone (MVK), a Potential Genotoxic Impurity (PGI), in Ivabradine HCl. A limit level concentration of 0.5 ppm for MVK was calculated by applying the concept of Threshold of Toxicological Concern (TTC). The developed HPLC method employs a Phenyl analytical column (150 mm х 4.6 mm, 3.5 μ), 5-μL injection volume, mobile phase of buffer (pH 2.5)-acetonitrile [gradient elution], a column temperature of 50°C and a flow rate of 1.0 mL/min. The retention time of MVK obtained was approximately 4.0 minutes in a program with run time of 22 minutes. The Limit of Detection was 0.06 ppm and Limit of Quantitation was 0.2 ppm. The method proved to be sensitive, linear, accurate and precise in the specified range (LOQ to 150 % of limit level concentration). The validated method was applied for identification and quantification of MVK in different batches of the...
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Posted by admin on Jan 31, 2017 in |
It is the most important part of pharmaceutical dosage forms; transdermal drug delivery system (TDDS) established itself as an integral part of novel drug delivery systems. On the application of Transdermal patches, the delivery of the drug across dermis gives the systemic effect. TDDS is costly alternative to conventional formulation. It is also important due to its unique advantage. Controlled absorption, more uniform plasma levels, improved bioavailability, reduced side effects, painless and simple application and flexibility of terminating drug administration by simply removing the patch from the skin are some of the potential advantages of transdermal drug delivery. Development of controlled release transdermal dosage form is a complex process involving extensive efforts. This review article describes the methods of preparation of different types of transdermal patches. In addition, the various methods of evaluation of transdermal dosage form and advance development in TDDS have also been...
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Posted by admin on Jan 31, 2017 in |
Metformin, an AMPK activator, acts as an oral hypoglycaemic agent. It reduces the risk of cancer during the treatment of diabetes and diabetes associated cancers. The effect of metformin on different type of cancers is explained on the pathway of AMPK activation involving hepatic fatty acid oxidation, inhibition of triglyceride and cholesterol synthesis and also modulation of insulin secretion. There is evidence of reduced risk on cancer incidence and mortality in diabetic patients 13. The inverse association was significant for pancreatic and hepatocellular cancer and non-significant for colon, breast and prostate cancer. Metformin associated with a decreased risk of cancer incidence compared with other treatment among diabetic patients. The main process for reducing cancer risk in diabetic patients is the lowering of the uptake and utilisation of nutrients into the biomass needed to produce a new cell from an active proliferating cell. Many observational studies in favour of Metformin as an antineoplatic agent reported but the confirmed report may be forwarded in the near...
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Posted by admin on Jan 31, 2017 in |
Aerosol drug delivery systems are much more importance in present days and have much advantage over other route of administration. Meter dose inhaler was used to deliver asthma medication in easy way and reliable multi dose preparation. The importance of the MDIs device play important role in determining drug delivery to the lungs. The word validation means,” Impose of validation or action of proving its effectiveness”. The most used inhalation is the metered-dose inhaler(MDI), which operates by delivering from a pressurized container using a liquefied gas propellant. Inhalation is the accessible way to deliver drugs to respiratory track and used in treatment of disease like ASTHMA.A manufacturer can assure that the design of the device, processes, process controls and packaging that all manufactured units will have to meet specifications and have uniform and consequent quality. Validation is defined as the collection and checking of data, from the process design stage throughout commercial production, which provides scientific evidence that a process is capable of consistently delivering quality...
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