Posted by admin on Jan 31, 2017 in |
The aim of this study was to develop oil in water nanoemulsion of nimodipine intended for oral use. Nimodipine is a calcium channel blocker that has poor oral bioavailability (3-30%) due to its low solubility and first- pass metabolism. So, nanoemulsion of nimodipine increase its solubility and enhance its oral bioavailability. Pseudo -ternary phase diagrams were made by using aqueous titration method. Nanoemulsions of pseudo-ternary phase diagrams composed of S mix (mixture of surfactant and co- surfactant), oil and deionized water. These nanoemulsions subjected for thermodynamic stability tests in order to select optimized formulations. Nimodipine nanoemulsions were subjected for characterizations studies in order to select the optimized formula. The characterizations studies explain that the optimized formula NE5 composed of 0.6% of nimodipine, 25% of S mix (2:1) that mean (16.66% tween 20: 8.33% PEG400), 10% of oleic acid and 64.4% of deionized water. The optimized formula NE5 characterized by droplet size (50 – 81.2 nm), polydispersity index (0.01), pH value (6.51), higher zeta potential (- 45.6 mV), drug content...
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Posted by admin on Jan 31, 2017 in |
Halobetasol propionate (HP) is an ultra-potent corticosteroid used in management of severe and recurrent cases of Atopic Dermatitis (AD). The marketed cream formulations are based on synthetic surfactants which often aggravate AD. The present studies investigate biocompatible pluronic lecithin organogel (PLO) of Halobetasol propionate in management of AD. Organogels were prepared by aqueous titration method and preliminary ternary phase studies optimized the ratio of surfactant (phospholipon 90G) to co-surfactant (propylene glycol).The optimized organogel comprised of surfactant and co- surfactant in ratio of 2:1, which exhibited satisfactory morphology and rheology. Systematic analysis by employing statistical models revealed that increasing concentration of lecithin and pluronic enhanced the viscosity of formulation and inhibited drug release. The developed formulation showed enhanced drug retention in skin as compared to marketed HP cream in ex-vivo permeation studies across rodent skin. Increased and deeper layer permeation from the PLO was confirmed by confocal microscopy using a fluorescent marker. Histopathological evaluation of excised skin from treated rats revealed non-irritating nature of the PLO. The present studies indicate...
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Posted by admin on Jan 31, 2017 in |
Objective: The present study was designed to evaluate the anti-diabetic activity of ethanol extract of Praecitrullus fistulosus leaves on streptozotocin induced diabetic rats. Materials and Methods: The anti-diabetic activity of plant leaves was investigated in streptozotocin induced diabetes model. Effect of ethanol extract of Praecitrullus fistulosus (EPF) leaves on normal blood glucose levels and oral glucose tolerance test were studied in normoglycemic rats while antidiabetic effect was evaluated in streptozotocin-induced hyperglycemic rats. EPF (200 and 400 mg/ kg) was administered orally for 21 days. Glibenclamide (5mg/kg, orally for 21 days) was used as reference standard. Results: Administration of the EPF caused significant dose‑dependent reduction in blood glucose in both normoglycemic and hyperglycemic rats and also improved glucose tolerance test. EPF reduced glycosylated hemoglobin, lactate dehydrogenase and creatinine kinase levels in streptozotocin treated animals. The extract also ameliorated oxidative stress Parameters -TBARS, catalase and superoxide dismutase activity and glutathione content. Conclusion: The ethanol extract of Praecitrullus fistulosus (EPF) leaves exhibited antidiabetic activity possibly through increased secretion of insulin and the...
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Posted by admin on Jan 31, 2017 in |
Saponins are the foam producing secondary metabolites of plant. They have been evaluated for a number biological activities like anticancer, anti-inflammatory, hepatoprotective, antimicrobial, antitumor, blood cholesterol lowering properties etc. In the present study we have attempted to check the role of isolated saponins from Asparagus filicinus for its hypolipidemic activity. Saponin rich fraction of Asparagus filicinus was extracted by microwave assisted extraction technique. Phytochemical analysis and characterization was performed using FTIR technique comparing it to the standard spectra of saponins. Preliminary anti hyperlipidemic activity was evaluated using Triton WR 1339 model. This experiment shows significant reduction in total cholesterol, triglycerides, LDL and HDL level in comparison with Atorvastatin standard...
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Posted by admin on Jan 31, 2017 in |
Background: Kapikacchu (Mucuna pruriens (L.) DC.) belonging to the family Fabaceae is commonly known as Velvet bean, Cowitch, Cowhage in English and Kawaanch, Kavach in Hindi. It is mainly distributed in Asia, Africa, Pacific Islands and the United State. Kapikacchu is very famous plant for its aphrodisiac effect. Traditionally it is being used as a potent antiparkinsonian, anti-inflammatory, aphrodisiac and nervine tonic. In market two types of seeds (black and white) are available and are being used simultaneously in the name of Kapikacchu. No data is yet available in context of the comparative pharmacognosy of black and white seeds of Kapikacchu. The aim of present article is to put forward the comparative pharmacognostical analysis of both types of Kapikacchu seeds. Methods: Macroscopic evaluation, microscopic evaluation, physicochemical evaluation, extractive values, phytochemical analysis, T.L.C. study were carried out using both varieties of Kapikacchu seeds and comparative data was obtained. Results: Data pertaining to the above cited evaluations was recorded for both varieties of seeds of Kapikacchu. Conclusion: All the values hence...
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