Posted by admin on Dec 31, 2016 in |
Let G be a simple molecular graph with vertex and edge sets V(G) and E(G), respectively. In 1972, Gutman and Trinajstić introduced the First and Second Zagreb topological indices of molecular graphs. These topological indices are useful in the study of anti-inflammatory activities of certain chemical instances, and in elsewhere. In this present study, compute the First Zagreb index Zg1(G)= and Second Zagreb index Zg2(G)= and the First Zagreb polynomial Zg1(G,x)= and the Second Zagreb polynomial Zg2(G,x)= of V-Phenylenic Nanotubes and...
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Posted by admin on Dec 31, 2016 in |
Antidiabetic potential of leaf and root extracts of Withania somnifera from Nimuch, Lucknow, Mumbai and Karnataka regions of India were evaluated against 3T3F442A fibroblast (3T3 adipocyte) cell line using glucose uptake assay. Leaf extracts from all the four regions were active on the cell line tested. Samples from Mumbai region found to be more active when compared with other regions. Root extracts also gave good glucose promoting activity in the presence of insulin. Nimuch samples were mere active than Mumbai samples. Isolated fractions and standard Withaferin-A and Withanolide-A were active at 20 µg/ml. This concentration was higher than that for crude leaf extract from Mumbai region and crude extracts from Nimuch region. Crude extract of Withania somnifera have good antidiabetic potential indicating the synergistic effect of these extract on glucose uptake of 3T3 fibroblast in presence of...
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Posted by admin on Dec 31, 2016 in |
Let G=(V,E) be molecular graph with vertex set V (G) and edge set E(G) in which the set of vertices and the set of edges of the graph correspond to the atoms of the molecule and chemical bonds, respectively. We denote d(u,v) the distance between u and v i.e the length of the shortest path connecting u and v. The eccentricity of a vertex in V(G) is defined to be Recently, we proposed the fifth atom-bond connectivity index of a simple connected graph G as . In this paper, we present more study of the fifth atom-bond connectivity index and compute this new index of polycyclic aromatic...
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Posted by admin on Dec 31, 2016 in |
Background: Vidang (Embelia ribes Burm. f.) is a very famous plant for its anthelmintic activity. In Ayurveda, it is a first choice of drug for its krimighna action or to kill foreign pathogens. Embeliaro busta auct. Nonroxb., the other species of vidang is adulterated in Embelia ribes Burm. f. Therefore shastrokta or original vidang and its adulterant species were selected for the comparative study. Methods: Both aqueous and alcoholic extracts of fruits of both species of Embelia at 10, 20, 30% concentrations were tested for antimicrobial activity by agar well diffusion method against a range of gram-positive and gram-negative bacteria. Zone of inhibition of extracts were determined, then activity index and IC50 value was calculated. Results: Both ethanol and Aqueous extracts of Embelia ribes Burm. f. and Embeliaro busta auct. Nonroxb. inhibited the growth of all the tested strains of bacteria. Aqueous extract Embelia ribes Burm. f. has more potent action against microorganism Staphylococcus aureus, Escherichia coli, Klebsiellaaerogenes, ZOI (16mm,14mm,19mm respectively), AI(0.64, 0.78, 0.70 resp.), IC50 (1.751, 1.166, 1.641...
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Posted by admin on Dec 31, 2016 in |
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) in addition with Nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs) used in the treatment of HIV-1 infection. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) gained exact place in the treatment of HIV-1 infections. Starting from the HEPT and TIBO derivatives, different classes of compounds have been identified as NNRTIs, that is compounds that are specifically inhibitory to HIV-1 replication and targeted at the HIV-1 reverse transcriptase (RT). Two NNRTIs (nevirapine and delavirdine) have been formally licensed for clinical use and several others are (or have been) in preclinical and: or clinical development [tivirapine (TIBO R-86183), loviride (a-APA R89439), thiocarboxanilide UC-781, HEPT derivative MKC-442, quinoxaline HBY 097, DMP 266 (efavirenz), PETT derivatives (trovirdine, PETT-4, PETT-5) and the dichlorophenylthio (pyridyl) imidazole derivative [S-1153]. Several compounds acting as Reverse transcriptase inhibitors was proved to be highly valuable against HIV-1 replication with minimal toxicity. NNRTIs interact with a specific ‘pocket’ site of HIV-1 RT and thus inhibiting the translocation and further elongation of DNA strand. The major drawbacks...
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