Posted by admin on Oct 31, 2017 in |
The aim of the present article was to examine the protective effect of ferulic acid against liver cholestasis in female rats treated with ethinylestradiol (EE). The daily oral administration of the ferulic acid at a concentration of 40 mg/kg body weight for 15 days to rats treated with EE (100 µg/kg body weight for 5 days) resulted in a significant protection against EE-induced decrease in plasma cholesterol, bile acid, hepatic reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (Gpx), and catalase (CAT) levels as well as against an increase of plasma bilirubin, alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT), malondialdehyde (MDA), 5′- Nucleotidase, interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α). The results clearly suggest that ferulic acid has a powerful prophylactic action in cholestasis induced by...
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Posted by admin on Oct 31, 2017 in |
The present work concern the production of activated carbon of reasonably good properties from cheep sources. The results of preparation of activated carbon from compressed wood sheets residues used in the furniture industry are presented. The preparation method entails the conversion of the wood sheets to a small size pellets and reacting these pellets with the activating agent FeCl3 (3% w/w). The mixture was heated at 300 oC for a period of 3 hours. The product was allowed to cool to room temperature, followed by carbonization at high temperatures with KOH. The effects of carbonization time periods of 3 and 12 hours and the ratios of wood pellets to potassium hydroxide (1:0.5, 1:1, 1:1.5 and 1:2) were investigated in order to determine the best operating conditions. The quality of the activated carbon produced was assessed by different methods such as density, humidity, ash content, iodine adsorption and the ability for methylene blue pigment removal from aqueous solution. The density of product decreases with increasing the carbonizing agent ratio. Humidity...
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Posted by admin on Oct 31, 2017 in |
Infectious diseases are among the most important common diseases worldwide that bring stupendous costs for human community. Medicinal plants are considered a rich source of antimicrobial agents and therefore can be used as antimicrobial remedies because of producing secondary metabolites. This article was designed to review the effective medicinal plants on fungi and fungal disease. In this study, the relevant articles published in Persian and English languages were searched for in the databases Magiran, Iranmedex, Irandoc, PubMed, Scopus, SID, Web of Science, and Science Direct using the search engine Google Scholar. To maximize the comprehensiveness of the search, the general terms antimicrobial, dermatophyte, mycotic, Iran, and anti-Candida as well as their Persian equivalents were used. AND and OR were used for combining searches. Medicinal herbs such as Zataria multiflora, Thymus vulgaris, Thymus kotschyanus, Punicagranatum L., Rosmarinus officinalis L., Matricaria chamomilla L., Urtica dioica L., Mentha piperita L. and Salvia officinalis L., Thymus vulgaris, Salvia officinalis, Eucalyptus globulus, Mentha piperita, Oliveria decumbens, Echinophora Platyloba, Thymus eriocalyx and Thymus X-porlock, Achillea...
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Posted by admin on Oct 31, 2017 in |
Lagerstroemia speciosa is commonly known as crape myrtle belonging to the Lythraceae family. Lagerstroemia speciosa or Banaba is a medicinal tree traditionally used to lower blood sugar in the body. Its high content of corosolic acid makes it an effective anti-diabetic drug. Banaba is also recommended for kidney, bladder problems and hypertension. Leaves of the species have been traditionally used over thousands of years as folkloric treatment by the native Indians and Japanese for illness, ailments particularly for lowering blood sugar levels and weight loss. The flower extracts of the species has some pharmacological properties like antioxidant and anti-microbial activities, whereas fruit extracts reported anti-nociceptive, anti-diarrhea and cytotoxic activities. Research on leaf extracts reveals that anti-bacterial, anti-viral, anti-inflammatory, anti-obesity, anti-fibrotic, anti-diabetic and xanthine oxidase inhibition, diuretic, decongestant activities and roots are applied for treating mouth ulcers. In addition to that bark is used to relieve the abdominal pains. The species also has essential metals like sodium, potassium, iron, zinc and magnesium which were clinically proved. Thus these reviews will...
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Posted by admin on Oct 31, 2017 in |
The aim of the present investigation was to prepare and evaluate novel bioadhesive vaginal microspheres containing Terbinafine (TBH) in order to provide long-term therapeutic activity at the site of infection and prove the same using in vitro anti fungal activity of the same using Candida albicans. Microspheres were prepared by the Solvent extraction technique using sodium hyaluronate and Arlacel A. Microspheres were characterized by SEM, DSC, FTIR, particle size analysis and evaluated for percentage yield, drug loading, encapsulation efficiency and in vitro drug release. FTIR and DSC studies showed that no chemical changes or alterations occurred in the drug and polymers. The sphericity factor indicated that the prepared microspheres were spherical. Formulation (TBHMs) indicated a controlled in vitro drug release and good bioadhesive strength. The in vitro anti fungal activity confirmed for a controlled and prolonged capacity of the prepared novel formulation. The results indicated that this drug delivery system can be explored for controlled intra-vaginal drug...
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