Posted by admin on Sep 30, 2017 in |
The present research was aimed to formulate erosion based matrix tablets of ketoprofen micro-sponges for spatial-colon targeting. For the optimization, the effects of independent variables like solvent volume and concentration of chitosan were studied on the mean particle size, percent entrapment efficiency (% EE) and in vitro drug release. Scanning Electron Microscopy (SEM) image of the micro-sponge formulation revealed that the surface of the micro-sponge was nearly spherical and porous. Optimized micro-sponge formulation was further formulated into erosion based matrix tablet and evaluated for quality control parameters. In vitro release studies revealed that both the micro-sponge formulation and micro-sponge matrix tablet (MST) had restricted the drug release of ketoprofen in gastric pH followed by gradual release up to 12 hr. The release kinetics data, after fitting into various models revealed that both formulations were best fitted to zero order, indicating controlled release property. The pharmacokinetic evaluation of colon targeted MST in rats revealed the presence of drug in plasma after lag time of 4 hr, tmax of 4 ±...
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Posted by admin on Sep 30, 2017 in |
Background: Influenza and influenza like illness (ILI) is a common respiratory illness among HIV patients. ILI is caused by various respiratory viruses and bacteria other than influenza virus. The symptoms of ILI recover within a few days, but in HIV patients ILI with opportunistic coinfections may lead to serious complications and hospitalization. Objective: To determine the incidence of human rhinovirus (HRV) coinfection with Staphylococcus aureus among HIV patients suffering from flu like illness. Materials and Methods: In this study 92 throat swab samples of flu suspected HIV patients were collected from Department of Immunology, SGPGIMS, Lucknow and ART Centre, RMLIMS, Lucknow, during 2014 – 2015. Samples were cultured on mannitol salt agar (MSA) plates, Staphylococcus aureus were confirmed by the biochemical characterization. The confirmation of HRV was done by RT-PCR. HeLa cell lines were used for isolation of human rhinovirus. Results: The prevalence of HRV was found 17 (18.5%), while S. aureus were isolated from 40 (43.5%) samples. Coinfection of S. aureus was found in 11 HRV positive samples...
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Posted by admin on Sep 30, 2017 in |
Objective: To examine anxiety levels and depression level of women diagnosed with gestational diabetes mellitus (GDM) and to compare these with glucose-tolerant (GT) women at similar stages of pregnancy. Research Design and Methods: Prospective longitudinal study conducted on 50 women with GDM and 50 NGDM women at 24 – 36 weeks of pregnancy. We are depended on Taylor anxiety Scale the Arabic version with reliability and Beck Depression Scale the Arabic version. Results: Women with GDM, compared with GT women, had a higher level of anxiety, depression scales, older, with low income, illiterate, and high BMI. Conclusions: Higher level of anxiety, depression scales, with low income, illiterate, and high BMI most causes of gestational...
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Posted by admin on Sep 30, 2017 in |
The threats and risks of the invalid drugs as expired, counterfeit (cheated drugs), Substandard, spurious, falsely labeled, falsified) .The risks and threats of the invalid drugs are many and wide vary, and the countries are trying to prevent these threats by some efforts as the regulatory institution’s efforts and the recorded expire date on the drug container, but that are not enough to prevent this problem. As well as, the recorded expire date on the drug container can be cheated and not accurate, too. As it depends on the assumption the drug may be valid till this date if the drug is made and stored in an ideal manner, but in the real conditions the drug may expose to different conditions that may effect on its expire date and validity, as the environmental conditions e.g. light and temperature. So, in this research I found some answers about the people and invalid drug, and about the trust in drug use and safety, and I developed an additional, simple, rapid and...
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Posted by admin on Sep 30, 2017 in |
Introduction: Experimental studies have found that acute stress leads to pathophysiological changes in cardiac risk profile and thereby more directly explain a link to cardiovascular disease. The present study was undertaken to evaluate the effect of Emblica officinalis versus placebo on mental stress induced changes in cardiovascular hemodynamic parameters and arterial wave reflection properties in healthy human subjects. Materials & Methods: In this randomized, double-blind, placebo-controlled, crossover study, participants received either two capsules of standardized Emblica officinalis fruit extract 250 mg or placebo daily for 2 weeks, as per prior randomization schedule. Pharmacodynamic parameters were recorded before and after a standardized mental stress test, at baseline and at the end of treatment. After a 2 week washout, participants crossed over to receive the other treatment. Results: A total of 12 volunteers completed the study. Compared to baseline, Emblica officinalis fruit extract produced a statistically significant decrease in Aortic augmentation pressure (from 6.6±2.15 to 4.6±2.02); (p< 0.01) and in Augmentation Index AIx (from 120.1±12.80 to 116.2±12.63); (p< 0.05). There was...
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