Posted by admin on Aug 31, 2017 in |
Hyperglycemia is a deleterious consequence of uncontrolled diabetes and an adverse effect of many common therapeutic drugs. Identification of drug-induced hyperglycemia is necessary for reducing morbidity or mortality associated with high blood glucose levels. The aim of the present study was to assess risk of unrecognized drug-induced hyperglycemia in patients admitted to King Abdulaziz Medical City (KAMC) in Riyadh, Saudi Arabia. All cases pertaining to hyperglycemia were identified from medical record archive of a random sample of patients admitted to KAMC, from January 2015 to December 2015. Patients with a previous history of diabetes were excluded from the study. The case/non-case method was employed to find association between identified drugs and hyperglycemia. The hyperglycemia risk was estimated by calculating the reporting odds ratios (ROR). The results reveal about one fifth of study population was admitted primarily due to hyperglycemia. A significant association for hyperglycemia has been shown with corticosteroids, immunosuppressants and anticholinergic agents with ROR = 2.63; 95% CI (1.26-5.51), ROR = 8.38; 95% CI (2.33-30.16) and ROR =...
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Posted by admin on Aug 31, 2017 in |
Global market of generic drug has been propelled by new government initiatives to produce generic drugs and to promote the use of generic drugs; thus the use of generic pharmaceutical products represents over half of the total volume of pharmaceutical products used worldwide. India is the world’s largest exporter of cost effective generic medicines and leading Indian generic companies are generating more than fifty percent revenue from the export business of generic drugs. After the expiry of patent or marketing rights of the patented drug, generic drugs can be marketed. Generic drugs are available at affordable prices with assured quality and therapeutic value. The decision on drug approval is taken only after being assured of its pharmaceutically equivalent and bioequivalent properties. According to an estimate from the World Health Organization (WHO), the percentage of population without adequate access to essential medicines is less than 1% in high-income countries, 24% in middle-income countries, and 39% in low-income countries, due to their high cost. Recently Govt. of India has launched a...
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Posted by admin on Aug 31, 2017 in |
The aim of the study was to prepare Temozolomide loaded solid lipid nanoparticles and evaluating loaded solid lipid nanoparticles. Temozolomide loaded solid lipid nanoparticles were prepared by micro emulsification method using different lipid (stearic acid) concentration keeping drug concentration unchanged, poloxamer 188 and cetyl alcohol as surfactant and co-surfactant. The prepared SLN were characterized for surface morphology by SEM analysis, drug loading and % entrapment efficiency, FTIR, zeta potential and in vitro diffusion studies. The lowest and highest % Entrapment Efficiency was found to be 85.85% and 97.45% for F1 to F5 batches respectively. Release studies were done by using saline phosphate buffer pH 7.4 using dialysis bag diffusion method. Zeta potential was found to be – 20.3 mV and particle size was found to be 119.34. For 8 hrs in vitro drug release found to be 79.16%, 74.45%, 71.42%, 61.36%, and 55.13% respectively. The release data was analysed by different kinetic models and found that the formulations best fit model is peppas and the drug release mechanism was...
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Posted by admin on Aug 31, 2017 in |
Objective: To study prescribing pattern for acute respiratory infections in children attending outpatient department of Paediatrics, J.L.N. Hospital, Ajmer, Rajasthan. Material and Method: The study was carried out retrospectively by analyzing the copies of prescriptions of patients who had visited the O.P.D. of the paediatrics department of J.L.N. Hospital Ajmer. A total of 350 prescriptions having written diagnosis ARI/URTI/common cold were selected for study. Information on demographic profile and treatment were spread over three different age groups (i.e. Neonates: up to one month of age, Infants: 1 month to 1year and Children: 1-14 years). Each prescription then was analyzed as per objectives of study. Results: Male patients were more as compared to females and most of the patients were in the age group of 1-14 years. Antihistaminics were the most frequently prescribed class of drugs (28.52%) followed by antimicrobials (26.35%). Antihistaminics constituted 63.08% of respiratory drugs prescribed. Antimicrobials were prescribed in 86.57% of the prescriptions and Cefpodoxime was the most frequently prescribed antimicrobial agent followed by Amoxicillin-clavulinic acid combination....
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Posted by admin on Aug 31, 2017 in |
Microspheres containing Repaglinide was prepared by emulsion solvent evaporation technique using two types of surfactants Tween 80 (polysorbate 80) and Span 80 (Sorbitanmonooleate 80). The effect of change in the type and surfactant amount on the size and drug release from the microspheres was investigated. The release of Repaglinide from the microspheres exhibit diffusional characteristics and closely follows Higuchi Model and also highly correlated with first-order release model. The in-vitro release study was performed in pH 6.8, phosphate buffer Solution and 0.1N HCl. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. In vivo testing of the microspheres in diabetic albino rats demonstrated significant antidiabetic effect of Repaglinide. Repaglinide loaded microspheres expected to give new choice for safe, economical formulation for effective management of NIDDM. A clear correlation between the types of surfactant on mean diameter of the microspheres was found. When Span 80 was used, the microspheres were smaller in size as compared to those obtained using Tween 80, while there was a...
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