Posted by admin on Jul 31, 2017 in |
Objective: Enhancement of oral bioavailability of poorly water soluble drugs is the most challenging aspects of drug development. It is very important to find appropriate formulation approaches to improve the aqueous solubility and bioavailability of poorly aqueous soluble drugs. Ezetimibe is a new lipid lowering agent in the management of hyper-cholesterolemia. The drug is water-insoluble, lipophilic, and highly permeable. Therefore, bioavailability of ezetimibe may be improved by increasing its solubility. Method: The aim of the present study was to improve the solubility and dissolution rate of Ezetimibe by preparing microspheres by spray drying technique using HP β-cyclodextrin. Ezetimibe microspheres containing different ratios of HP- β-cyclodextrin were produced by using Propanol and water (50:50) as a solvent system. The prepared formulations containing different ratios of Ezetimibe and HP β-cyclodextrinwere evaluated for solubility and in-vitro dissolution. The prepared formulations were characterized by differential scanning calorimetry (DSC), X-ray diffraction spectroscopy (XRD), fourier transform infra-red spectroscopy (FTIR) and scanning electron microscopy (SEM). Dissolution profile of the prepared spray dried microspheres was compared with...
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Posted by admin on Jul 31, 2017 in |
Synthesis of new organometallic Schiff bases complexes with general formula [ML)xH2O] [where M = Mn(II), Ni(II), Cu(II) Pd(II) and Pt(II), L=2,2′-{(1R,1′S)-1,1’Ferrocen-2,4-dien-1-yl-2,2′-diyl bis [(Z)methyl-ylidenenitrilo]}bis(3-iodophenol)] have been prepared and characterized by elemental analysis, magnetic susceptibility, Conductivity IR, UV-Visible, Mass spectra and TGA/DTA. Organometallic Schiff base is tetradentate and co-ordination through nitrogen of azomethine (>C=N-) and oxygen of Hydroxyl group. The complexes have octahedral geometry with six coordination number. Electronic spectra of the complexes were recorded and its parameters like Nephelauxetic effect (β), bonding parameter (b1/2) and Sinha’s parameter (δ %) are calculated. TGA and DTA results of [Pt (C24H16 FeI2N2O2).2H2O] and [Pd (C24H16 FeI2N2O2).2H2O] are reported, Complexes were losing weight due to exothermic and endothermic process. The mass spectra of prepared ligand (C24H18 FeI2 N2O2) and its complex such as [Mn (C24H16FeI2N2O2).2H2O] were used to compare their stoichiometric composition and it found that near about equal to the theoretical mass of the complex and prepared ligand. Synthesis of nanoparticles of OMNPs (organometallic Nanoparticles) of Cu(II) Complex with SEM and EDX were...
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Posted by admin on Jul 31, 2017 in |
Eessential oils are known to possess antimicrobial activity. This review article explains the antimicrobial reaction, application, effects, and characteristics of cinnamaldehyde. Amongst the different essential oils, Cinnamaldehyde is observed to be the most effective antimicrobial agent. The current studies on cinnamaldehyde in the field of microbiology have been highlighted. This review explains the different methods, those are used for antimicrobial evaluation. Additionally, the anti-physiologic effect of antimicrobial agents using microbial respiration rate is also...
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Posted by admin on Jul 31, 2017 in |
Hypothyroidism is a common disorder of endocrine system in which the thyroid gland does not produce enough thyroid hormone. The most common cause of hypothyroidism is inflammation of the thyroid gland, which damages the gland’s cells. It can affect growth, cellular processes and many other body functions. As more damage accumulates, the risk of Hypothyroidism increases. In order to make an impact on Hypothyroidism, we must understand the molecular processes and structure-function relationships of TSH permitted better understanding of the role of specific protein and carbohydrate domains in the synthesis, bioactivity, and clearance of this hormone. Thyroid hormone receptor alfa-1 (THRA1) is an endocrine nuclear receptor that mediates the transcriptional effects of thyroid hormone (triiodothyronine, T3). It acts as an agonist i.e. it stimulates the production of thyroid hormone by triggering a response in the cell, which is selected as target protein. The primary goal of the project was to unearth natural chemical compounds that can be used as an agonist (increase thyroid hormone level in patients) for the...
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Posted by admin on Jul 31, 2017 in |
A new series of Cu(II), Zn(II) and Co(II) complexes have been synthesized from 6-Methoxy-3-phenyliminomethyl-chromen-4-one, a Schiff base derived from 6-Methoxy-4-oxo-4H-chromene-3-carbaldehyde and aniline. The nature of bonding and the structure of the complexes have been deduced from IR, UV, 1H NMR spectroscopy. The biological activity of the ligand and metal complexes have been examined against both gram-positive as well as gram-negative bacteria by the Agar well method using DMSO as solvent and Gentamicin as standard drug. The zone of inhibition values and MIC were measured at 37 ºC for 24 h. Antimicrobial screening tests displayed better results for the metal complexes as compared to the...
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