Posted by admin on Jul 31, 2017 in |
Members of the tribe Anthemideae (Asteraceae) attract considerable medicinal attention worldwide and are used for the treatment of many infectious and degenerative diseases in humans due to their biologically active compounds. The aim of this study was to evaluate the antioxidant property of total phenolic compounds (TPC) and flavonoids (TF) in the capitula of 41 representatives and endemic taxa belonging to seven genera (Achillea, Anthemis, Artemisia, Glebionis, Matricaria, Tanacetum and Tripleurospermum) native to Turkey. The results of the experiments showed that the phenolics of the taxa were significantly correlated and associated with their antioxidant capacity values. Our findings will be useful to researchers and others who are interested in the antioxidant potentials of the herbs as dietary supplements. This is the first report to describe the phenolic compound and antioxidant capacity values of capitula only in selected taxa of...
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Posted by admin on Jul 31, 2017 in |
A simple, precise and accurate RP-HPLC method was developed for the determination of Plerixafor in bulk and pharmaceutical dosage forms. The estimation was carried out on Xterra RP 18 (4.6 x 250mm, 5µm) column using a mixture of Methanol: Water (50:50% v/v) as the mobile phase at a flow rate of 0.8ml/min, the detection was carried out at 215nm. The method was validated for linearity, accuracy, precision, specificity, limit of detection and limit of quantification and robustness as per ICH norms. The retention time of the Plerixafor was 5.481 min. The method produce linear responses in the concentration range of 10-50mg/ml with correlation coefficient (r2) of 0.999. The proposed method is useful for the estimation of plerixafor in its pure and injection dosage...
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Posted by admin on Jul 31, 2017 in |
Heparin-induced thrombocytopenia (HIT), a devastating immune mediated adverse drug reaction, is triggered by the development of antibodies that stimulates the platelet activation in presence of heparin. Bleeding is infrequent in HIT patients regardless of thrombocytopenia; however, HIT is strongly associated with thromboembolic complications involving both venous and arterial systems. Numerous novel oral anticoagulants exist that may be beneficial for HIT, principally in cases refractory to standard therapies. However, these agents have not been fully evaluated for treatment of patients with HIT and hence none have FDA approval for use in HIT. Diagnosis of HIT is a bit challenging because of the routine use of heparin in hospitalized patients, which is one of the common consequences of thrombocytopenia. Numerous laboratory tests are available to confirm the diagnosis of HIT, but its clinical suspension remains crucial to the early cessation of heparin and initiation of alternative therapy. Treatment includes the initiation of alternative anticoagulants resulting in the reduced prevalence of...
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Posted by admin on Jul 31, 2017 in |
The tradition of home treatment is found in all cultures throughout the world whether in developed or developing countries. Few herbal drugs commonly appear in the home use as a medicine. One such drug is Zanjabeel, it is the rhizome of Zingiber officinale Rosc. It is a popular culinary spice that was used as an important medicine by ancient Unani physicians. It is a very important drug of house hold medicine kit used mainly as antiflatulant, digestive, anti cough and other indications mentioned in traditional Unani text. Beside its traditional uses its new indications are as an, ant-emetic, hypocholesterolaemic antioxidant, antimicrobial, cardioprotective etc. Unani medicine has provided lot of information regarding this drug. Fresh look on the indications of Zanjabeel is needed in the light of current research performed on it and further scope of research can also be explored with the help of traditional knowledge exist in Unani medicine. This review is an attempt in this direction, so that Zanjabeel can become more beneficial to ailing people and...
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Posted by admin on Jul 31, 2017 in |
Transition metal doped zinc oxide particles were synthesized in aqueous phase adopting a low cost, easy and environmental friendly route. The precursors used in the preparation of Co doped ZnO (Zn0.95Co0.05O) and ZnO (Zn0.9oCo0.1O) by wet process are zinc acetate dehydrates cobalt chloride, sodium hydroxide, di-ethylene glycol and double distilled water. The doped ZnO particles were characterized by using scanning electron microscope (SEM), energy dispersive X-ray (EDX), Fourier transforms infrared spectroscopy (FTIR). The study constitutes the basis for developing versatile applications of transition metal doped ZnO...
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