Posted by admin on Jun 30, 2017 in |
The purpose of this research work is to determine whether Metafol-L improves sensory neuropathy in patient with Type 2 diabetes or not. In patients with diabetes mellitus, prolonged hyperglycemia can result in peripheral neuropathy (pain and/or loss of sensation in the extremities). Neuropathy issues may be related to Vitamin B deficiencies; therefore, the supplementation of Vitamin B12, Vitamin B6, and folate (Vitamin B9) may improve diabetic peripheral neuropathy (DPN). Metafol L is a product containing L-methyl folate, pyridoxal 5 phosphate, and methylcobalamine for management of endothelial dysfunction. Metafol-L ingredients counteract endothelial nitric oxide synthase uncoupling and oxidative stress in vascular endothelium and peripheral nerve. Studies of monotherapy with l-methylfolate, methylcobalamine and pyridoxine 5 phosphate suggest that each of these bioavailable B vitamins may reverse the pathophysiology and symptoms of DPN. After approximately six month of treatment, patient undergoes follow up biopsy. At the end of their treatment 79% of patient showed an increase in calf ENFD & 87% of patient show experienced both reduced frequency and integrity of paraethesias...
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Posted by admin on Jun 30, 2017 in |
Pharmaceutical impurities are the organic and inorganic unwanted chemicals which are found in active pharmaceutical ingredient after synthesis or develop during formulation development. These impurities severely affect the safety and efficacy of developed pharmaceutical product. Impurity profiling detects and quantifies the levels of organic and inorganic impurities and thereby helps in better monitoring of quality, stability and safety of pharmaceutical products. Regulatory bodies worldwide are serious towards presence of impurities and impurity profiling has thus become an important step in filling drug dossiers. The ICH guidelines on impurity have clearly defined the levels of toxic impurities and have become benchmark in establishing impurities in pharmaceutical drug products. The present article summarizes the concept of impurity profiling and also presents a case study on impurity profiling of methamphetamine hydrochloride to illustrate its significance. Further a case study is presented on quantification of active pharmaceutical ingredient and impurities in sildenafil citrate purchased via internet and its relative...
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Posted by admin on Jun 30, 2017 in |
To study the analgesic and antipyretic activities of ethanolic extract of Bambusa arundinacea leaves (EEBA) in rats by using models tail immersion test, hot plate test and brewer’s yeast pyrexia model. Methods: The dried powdered leaves were extracted with ethanol and the resultant extract was subjected for phytochemical investigation to identify different phytoconstituents. Analgesic activity of the ethanolic extract of B. arundinacea leaves at a dose of 100mg/kg b.w., p.o. and 200mg/kg b.w., p.o. were evaluated against the standard drug Diclofenac sodium at a dose of 10mg/kg b.w., i.p. by tail immersion test and hot plate test. Antipyretic activity of EEBA (100 mg/kg and 200 mg/kg) was assessed by using brewer’s yeast pyrexia model in rats against the standard drug Paracetamol (150 mg/kg, p.o.). Results: Preliminary phytochemical investigations showed the presence of flavonoids, alkaloids, steroids, carbohydrates, proteins and amino acids, tannins and phenolic compounds as major secondary metabolites. The results showed that in tail immersion and hot plate test, EEBA has shown significant (P < 0.05) increase in the...
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Posted by admin on Jun 30, 2017 in |
Post-operative delirium is transient global disorder showing reduced cognition, altered consciousness and psychomotor activity as well as deranged sleep-wake cycle. For elderly patients undergoing hip surgery, the reported incidence varies from 16% to 62% with average rate of 35%. Pharmacotherapy management of post-operative delirium may entail use of drugs belonging to groups like sedatives, antipsychotics, analgesics and others. The aim of this study was to assess the efficacy and safety of diazepam compared to haloperidol in post-operative delirium. A retrospective analysis of all elderly (>65 years) undergoing hip surgery in our department between 2014 to 2016 was done to identify patients developing post-operative delirium and those treated with Diazepam or with Haloperidol were divided in separate groups. We compared these groups for parameters like duration of postoperative hospital stay, duration of delirium, number of patients showing complications and adverse events. Total 506 patients meeting inclusion criteria were identified. Of these, 188 patients were found to have been diagnosed with post-operative delirium. 55 patients were treated with diazepam (Group A)...
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Posted by admin on Jun 30, 2017 in |
Solanum nigrum is a well known traditional medicinal plant. This study was intended to isolated active compound from the Solanum nigrum leaf. Solanine were isolated and purified from leaves of Solanum nigrum by using acid extraction along with alkaline precipitation methods and results shows that leaves of Solanum nigrum found to good sources of Steroidal glycol-alkaloids together with their structure were evaluated using various spectroscopic data of UV, FTIR, HPLC, NMR as well as MS. Anti-oxidative effects of solanine were tested in the in vitro (DPPH, superoxide anion radical and the hydroxyl radical) furthermore antibacterial activity were analysed against pathogens E. coli, Staphylococcus aureus, Salmonella typhi – A and Pseudomonas aeruginosa and its cytotoxicity effects were tested using Hep-2 and AGS cell...
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