Posted by admin on Jun 30, 2017 in |
Vascular malformations are one of the most common lesions of the oral cavity. The lesion may be a congenital malformation observed in neonates or arteriovenous malformation observed in adults. The treatment of these lesions includes surgical excision, cryotherapy, selective embolization and treatment with intralesional sclerosing agents. We present two cases of benign oral vascular lesions treated with intralesional injection of 30mg/ml sodium tetradecyl sulfate. One lesion virtually disappeared after one session of sclerotherapy, leaving a fibrotic lesion. No side effects were observed. The other lesion resulted in a severe inflammatory response including pain, swelling and surface ulceration up to more than 2 weeks. Sclerotherapy with sodium tetradecyl sulfate is effective in treating smaller benign oral vascular lesions, and the use of the sodium tetradecyl sulfate provides alternative or support for surgical methods. Larger lesions in critical anatomical areas may not be the best choice for treatment with Sclerosing agents. This paper presents the success and failure of vascular lesions treated with sclerosing...
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Posted by admin on Jun 30, 2017 in |
Biomarker is a measurable indicator of the severity or presence of some disease state. It is introduced into an organism as a means to examine organ function or other aspects of health. Biomarkers play a major role in medicinal biology. They help in early diagnosis, disease prevention, drug target identification, drug response etc. Several biomarkers have been identified for many diseases such as cancer, cardiac diseases, nutritional epidemiology, etc. Biomarkers play a significant role in cancer prognosis, diagnosis and treatment. With discovery efforts on-going the next phase towards conversion will involve validation. This includes the steps needed to manage the new treatment model from treating clinical symptoms to targeting genomic pathways. Cardiac biomarkers are substances that are released into the blood when the heart is damaged or stressed. Measurements of these biomarkers are used to help diagnose acute coronary syndrome (ACS) and cardiac ischemia, conditions associated with insufficient blood flow to the heart. Diet is of key importance in affecting the risk of most chronic diseases in man. The...
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Posted by admin on Jun 30, 2017 in |
Ziprasidone HCl is a newly introduced atypical antipsychotic drug. It has its own unique multi receptor binding affinity. This makes it a unique special choice of antipsychotic agent. It mainly acts as antagonist of D2 dopamine receptors as and 5HT2A (serotonin, 5HT, 5-hydroxytryptamine) receptors. It is pinkish brown colored powder having very low solubility in water (21.12 mg/L). The main purpose of this study is to enhance the solubility of Ziprasidone HCl using lyophilisation technique. The β-Cyclodextrine and Hydroxy Propyl- β-Cyclodextrine were used as the water soluble carriers for increasing the solubility of Ziprasidone. All the inclusion complexes prepared by lyophilisation technique showed remarkable increase in the solubility compared to the pure Ziprasidone HCl. The saturation solubility analysis demonstrated highest increase in the solubility of drug after complexation with HP-β-CD by lyophilisation technique. The inclusion complexes were characterized using DSC and XRD technique. During in vitro study result obtained that the lyophilized complexes with HPβ-CD showed 100% drug release within 10 min were as the lyophilized complexes with β–...
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Posted by admin on Jun 30, 2017 in |
Cancer is a major public health burden in both developed and developing countries. It is an abnormal growth of cells in body that can lead to death and globally the numbers of cancer patients are increasing day by day. There are several medicines available in the market to treat the various types of cancer but no drug is found to be fully effective and safe. Herbal medicines have a vital role in the prevention and treatment of cancer. With advanced knowledge of molecular science and refinement in isolation and structure elucidation techniques, various anticancer herbs has been identified, which execute their therapeutic effect by inhibiting cancer-activating enzymes and hormones, stimulating DNA repair mechanism, promoting production of protective enzymes, inducing antioxidant action and enhancing immunity of the body. Plants have been used for treating diseases since time immemorial. More than 50% of modern drugs in clinical use are of natural products. In the present review, an attempt has been made to study the plants that have been used in the...
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Posted by admin on Jun 30, 2017 in |
Curcumin has been shown to inhibit the activation of nuclear factor-κB (NF-κB), which is closely linked to chemo-resistance, in multiple myeloma cells. Malignant cells of this kind typically develop progressive multidrug resistance. Our aim was to investigate new possibilities for overcoming this resistance by suppressing cell signaling pathways. MTT-dye reduction assay was used to evaluate the cytotoxic activity of degrasyn, curcumin and Arsenic (ATO) on U-266, RPMI-8226 cell lines. Carfilzomib served as reference drug. Western blot analysis was performed. In RPMI-8226 cells evident activation of caspase 3 by ATO was seen. PARP cleavage was detected after degrasyn treatment. Curcumin led to PARP degradation as well. Caspase 9 was found to be activated by ATO, degrasyn and Carfilzomib. LC3b (autophagy hallmark) level was increased after exposure to ATO, curcumin and degrasyn. In U-266 cells significant LC3b increase was recorded after carfilzomib treatment. Procaspase 9 was cleaved after curcumin usage. Degrasyn activated procaspase 3. Elisa test was performed. All substances showed inhibition of NF-κB p65 fraction in both U-266 and RPMI-8226...
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