Posted by admin on Mar 31, 2017 in |
Adverse drug reactions in the form of toxic epidermal necrolysis is a rare but potentially fatal disorder. The pathophysiology of such reactions are not properly understood. There are many drugs which are very often implicated for causing such severe reactions. Allopurinol is a common drug used in chronic gout but also notorious for causing Steven – Johnson syndrome and rarely toxic epidermal necrolysis. Very often such reactions may cause severe morbidity and even mortality. Here, we describe a case of fatal toxic epidermal necrolysis caused probably due to allopurinol use in a 62 year old male. The event required immeditae reporting as it lead to the death of the patient. Immediate treatment is essential for combating such reactions and caution should be practised while prescribing such drugs. Moreover intense reporting of such cases will help us in understanding the pattern of such reactions and take necessary and timely...
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Posted by admin on Mar 31, 2017 in |
In order to improve the water-solubility of curcumin, the complex between curcumin and hyperbranched poly(amide-ester) was formed by dispering the solid curcumin in hyperbranched poly(amide-ester) aqueous solution. The interaction process was characterized by UV-vis absorption spectroscopy, Fluorescence quenching method, Fourier transformation-infrared spectroscopy, thermogravimetric analysis. Fluorescence quenching ananlysis reveal that the fluorescence quenching of curcumin is due to the formation of ground state complex between curcumin and hyperbranched poly(amide-ester) and the binding constant was 3.98×105L·mol-1. The other analysis also can prove the formation of complex between curcumin and HBPAE. The solubility of curcumin in aqueous solution was greatly increased more than 1000-fold at the presence of hyperbranched...
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Posted by admin on Mar 1, 2017 in |
Mn(II) complexes with four semicarbazide and thiosemicarbazide based ligands such as 2-formyl pyridine semicarbazone (L1), 2-formyl pyridine thiosemicarbazone (L2), 5-methyl 2-formyl pyridine semicarbazone (L3) and 5-methyl 2-formyl pyridine thiosemicarbazone (L4) have been synthesized and characterized. All the ligands were characterized by elemental analyses, IR, 1HNMR and mass spectral studies. The complexes were characterized by using various physicochemical techniques such as elemental analysis, molar conductance, magnetic susceptibility measurements and spectral studies such as IR, UV-visible and EPR. The complexes were found to have general compositions Mn(L)2X2 [where L = L1, L2, L3 & L4, X = Cl–, NO3–]. The molar conductance data of chloro and nitrato complexes of L1, L2, L3 and L4 suggest nonelectrolytic nature of the complexes. Therefore they may be formulated as [Mn(L)2X2].Complexes show magnetic moment corresponding to five unpaired electrons. On the basis of IR electronic and EPR spectral data distorted octahedral geometry of complexes has been...
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Posted by admin on Feb 28, 2017 in |
Background: Diabetes poses a burden on the limited health care delivery system. Current pharmacological anti-diabetic agents cause undesirable side effects and are very expensive. Herbal remedies offer the potential for alternative treatment strategies. This study was therefore conducted in an effort to formulate a poly herbal medicine for management of diabetes. Methods: A stenophylla root bark was extracted with aqueous ethanol (70%) and quantitative analysis for total phenolic content, total alkaloids and flavonoids was carried out on the dried extract. The hypoglycaemic effects of aqueous A. stenophylla root bark extract, powdered Zingiber officinale and powdered Citrus Limon peels was determined on alloxan-induced diabetic rats singly and in combinations over 14 days. Glibenclamide administered at 0.2 mg/kg b. wt was used as the positive control. Results: All the plants decreased plasma glucose levels in a dose-dependent manner. The glucose levels of diabetic rats treated with all the plants combined showed the greatest reduction (59.2%). A. stenophylla and Z. officinale showed a glucose level reduction of 47.7%, A. stenophylla and C....
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Posted by admin on Feb 28, 2017 in |
Structural and thermal properties of silver/poly(vinyl alcohol) (Ag/PVA) nanocomposites has been investigated as a function of Argon ion beam fluence. The XRD patterns (X-ray diffraction) showed the formation of the Ag/PVA in polymer structure and phase analysis with different sizes as a function of either ion beam fluence or Ag+ ion molar concentrations. The kinetic parameters for the thermal stability of Ag/PVA were evaluated applying Thermal Gravimetric Analysis (TGA), the decomposition temperature increase from 302 0C for pure PVA to 345 0C for irradiated Ag nanofillers /PVA with ion beam fluence 3.0 x 1018 ions.cm-2 at 0.8 % AgNO3 concentration . Fourier transform infrared spectroscopy (FT-IR) exhibits the creation of polar groups on the surface which are responsible for surface wettability improvement. From the above, this procedure is simple and useful for large scale synthesis and which make this material as a candidate medical devices and for drug delivery...
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