1, 2, 4-TRIAZOLES: AS BIOLOGICALLY IMPORTANT AGENTSAbstract
The chemistry of heterocyclic compounds containing five membered 1, 2, 4-triazole nucleus has been an intresting field of study for past few decades. The five membered 1, 2, 4-triazole ring exists in two tautomeric forms i.e., 1H-1, 2, 4-triazole, 4H-1, 2, 4-triazole collectively known as s-triazoles. The s-triazole derivatives possess extensive spectrum of biological activities such as antibacterial, antifungal, antitubercular, anxiolytic, anticonvulsant, anti-inflammatory, analgesic, anticancer, antioxidant activities. The present review provides a broad view of pharmacological activity of compounds bearing 1, 2, 4-triazole nucleus. It can be useful for medicinal chemists to design and develop novel compounds consisting 1, 2, 4-triazole nucleus to get better agents in terms of efficacy and safety.
D. Kumudha*, R. R. Reddy and T. Kalavathi
Assistant Professor, Arya College of Pharmacy, Kandi, Sangareddy, Medak- 85, Andra Pradesh, India
02 August, 2012
20 September, 2012
10 November, 2012
01 December, 2012