1, 3, 4-OXADIAZOLE AND ITS POTENCY: A REVIEWAbstract
Heterocyclic compounds represent the important structural key in pharmaceutical medicinal chemistry. In literature, five-membered heterocycles are reported to be a core moiety of various pharmaceutical drugs. Oxadiazole or furadiazole is a five-membered heterocyclic nucleus and is considered to be derived from furan by replacement of two methane (-CH=) groups by pyridine type nitrogen. Oxadiazole is a versatile lead compound for designing potent bioactive agents. 1, 3, 4-oxadiazole having verities of potential biological activities can be synthesized by various methods. Hence, nowadays, researchers have developed innovative methods for the synthesis of 1, 3, 4-oxadiazole derivatives and their medicinal applications. The activities include anticancer, antimicrobial, anti-inflammatory, anti-HIV, anti-tubercular, anti-diabetic, antifungal, etc. In this review article, we have summarized various methods for synthesis of derivatives of 1, 3, 4 – oxadiazole nucleus and evaluation of various biological activities. The information in the present article may be useful to many researchers, which leads to the exploration of new therapeutic species for society.
Hasit Vaghani *, Shweta Patel and Sarika Patel
Department of Chemistry, Mehsana Urban Institute of Sciences, Ganpat University, Kherva, Mahesana, Gujarat, India.
19 August 2020
14 May 2021
24 May 2021
01 October 2021