IN- SILICO ANALYSIS OF MOST SUITABLE DRUG FOR PATHOGENIC BACTERIA CAUSING PERIODONTITIS
AbstractThe human oral cavity is a complex biological system in which members of a microbial community interact with themselves as well as with different host structures and components Neisseria sp., Haemophilus influenzae and Campylobacter jejuni cause periodontitis . The pathogenesis of this dental infection is a multi factorial process that results in a serious degenerative disease of the periodontium. Researches have resulted in the identification of important virulence factors. These researches have provided a narrow picture of the steps of this complex process. In contrast, a wider picture could be abstained with the application of tools such as bioinformatics and proteomics. These tools provide factors and process leading to the pathogenesis and treatment. In the present study Ferric binding protein is taken as a case study molecule to understand high reactive responses of various drugs administered for the oral periodontitis. The drugs are being compared with the Fbp. The Fbp interacted with doxycycline, flurbiprofen and chlorhexidine using docking methods.
Article Information
34
2942-2946
731
1125
English
Ijpsr
Vijayakumar Madhumathi* & Suburamaniyan Vijayakumar
Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Thanjavur, Tamil Nadu, India
16 July, 2011
21 August, 2011
30 October, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(11).2942-46
01 November, 2011
Download