2-AMINO-3-CYANOPYRIDINE: A BIOACTIVE SCAFFOLDAbstract
One of the most fascinating branches of pharmaceutical field is the chemistry of heterocyclic molecules. Heterocyclic compounds are widely distributed in nature and have biological and industrial significance. Already most of the drugs available in the market are heterocyclic in nature. Cyanopyridine, a structural motif is a cause of concern for biologist and chemist in last twenty years. Specifically 2-amino-3-cyanopyridine scaffolds demand importance due to their diverse biological activity like antiviral, antibacterial, and fungicidal activities, novel IKK-β inhibitors, A2A adenosine receptor antagonists, potent inhibitor of HIV-1 integrase. Due to high reactivity of this scaffold, it has been found as reactive chemical intermediates in organic synthesis like, commercial production of nicotinamide, and pharmaceuticals such as Ridogrel and Pirenzepine. In this short review we have focused on the recent development in synthesis of 2-amino-3-cyanopyridine derivatives and all possible pharmacology reported for this compound. This review may helpful for medicinal chemist in research regarding 2-amino-3-cyanopyridine in future.
Kuntal Manna, Partha Sakha Ghosh*, Manik Das, Udayan Banik and Ashish Das
Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Agartala, Tripura (West), India
08 December, 2013
11 January, 2014
09 April, 2014
01, June 2014