3D PRINTING IN PHARMACEUTICALS A COMPREHENSIVE REVIEW ON A NOVEL EMERGING TECHNOLOGYAbstract
Three-dimensional printing (3DP) is an emerging technology that allows the fabrication of tailor-made drugs, devices, and organs that meet an individual patient’s requirement. Thus, it has enormous potential to bring about a significant transformation in the pharmaceutical and healthcare sector. 3DP involves the production of structures with desired design by deposition of printing material in a layer-by-layer fashion. It permits on-demand fabrication of structures with high productivity economically. Currently, it is employed in a wide range of healthcare services such as drug formulations, medical devices, anatomical models, tissue engineering and regenerative medicine, engineered tissue models, and dentistry. The primary objective of this review to describe various approaches in personalized medicine, progress in dosage forms and devices, 3DP techniques, use of polymers in 3DP and adaptation of 3DP in pharmaceutical industries. We further describe recent approaches in the fabrication of conventional drug formulations and novel drug delivery systems and compare the 3DP with 3D bioprinting. Lastly, we discuss the limitations, regulatory aspects, and future trends of 3DP technology in the healthcare setup.
B. Devang Patel, Bhaumik Patel and H. Rutesh Dave *
Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, USA.
12 July 2021
25 October 2021
27 March 2022
01 May 2022