A COMPARATIVE INTERVENTIONAL STUDY ON EFFECTS OF CALCIUM CITRATE AND ISOFLAVONES ON LOW BONE MINERAL DENSITY IN PERIMENOPAUSAL WOMEN
AbstractPerimenopause is a transitional stage in a woman’s life, typically occurring in her 40s, leading up to menopause. During this time, hormonal changes, particularly a decline in estrogen levels, can have a significant impact on bone health. Calcium citrate is a commonly used calcium supplement that is known to promote bone health. Isoflavones are a type of phytoestrogen found in plants, particularlyin soybeans and soy products. The study aimed to compare the effects of calcium citrate and isoflavones on BMD in perimenopausal women with low BMD. 60 perimenopausal women with low BMD, aged 40-55 years, who were divided into two groups: Group A received Calcium citrate supplementation, while Group B received Calcium citrate+Isoflavones supplementation. BMD was measured at baseline and after 3 months using Dual-Energy X-ray Absorptiometry (DEXA). After 3 months, both groups showed improvements in BMD compared to baseline (p <0.05). The increase in BMD was greater in Group B (Calcium citrate + Isoflavones) compared to Group A (Calcium citrate) (p<0.05) Results revealed that the combination of calcium citrate with isoflavones showed a significant improvement in bone density and calcium absorption compared to calcium citrate alone.
Article Information
28
1717-1723
855 KB
50
English
IJPSR
Shaiju S. Dharan *, R. S. Adithyan, J. A. Amrutha and Dinesh Devika
Department of Pharmacy Practice, Ezhuthachan College of Pharmaceutical Sciences, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Trivandrum, Kerala, India.
shaijusdharan@gmail.com
20 January 2025
09 April 2025
23 April 2025
10.13040/IJPSR.0975-8232.16(6).1717-23
01 June 2025
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