A COMPERATIVE STUDY OF VANADIUM PENTOXIDE AND CHROMIUM OXIDE IN STREPTOZOTOCIN INDUCED DIABETES IN ALBINO RATSAbstract
Objectives: The present study was conducted to evaluate and compare the effect of vanadium pentoxide and chromium oxide in normal and streptozotocin induced diabetic albino rats. Methods: Diabetes was experimentally induced by injecting intraperitoneally with a single dose of 60mg/kg. The animals were considered as diabetic, if their blood glucose values were above 300 mg/dl on the 10th day after injection. The blood glucose estimation was done by glucose oxidase method. Glibenclamide was taken as standard drug. The one-way ANOVA followed by Dunnett’s ‘t’ test was used for statistical analysis. Results: The blood glucose levels were found to be significantly (p<0.05) decreased in vanadium pentoxide and chromium oxide treated groups. Conclusion: This study suggests that vanadium pentoxide and chromium oxide have antidiabetic effect in a dose dependent manner.
Pradumna Pathak* and Mangala Lahkar
Department of Pharmacology, Fakhruddin Ali Ahmed Medical College and Hospital, Barpeta, Assam, India
22 April, 2015
03 June, 2015
28 August, 2015
01 November, 2015