THE INTRIGUING BENZIMIDAZOLE: A REVIEWAbstract
Benzimidazole is a heterocyclic aromatic organic compound containing nitrogen. This bicyclic compound is formed by the fusion of benzene with imidazole ring. It is a vital Pharmacophore and privileged structure in medicinal chemistry which exhibits various therapeutic activities like antiulcer, antihypertensive, analgesic, antiviral, antifungal, anticancer and antihistaminic. The disease conditions targeted by these activities are discussed. The present article extensively covers various procedures of synthesis of 2-substituted benzimidazole and its analogs by utilizing different catalysts, solvent conditions, reactants and microwave irradiation with the aim to obtain an inexpensive, eco-friendly, less time-consuming procedure which ensures good yield and quick isolation of the pure product. Ongoing clinical trials of different benzimidazole derivatives exploring additional pharmacological activities are also covered.
V. K. Singh * and A. Parle
Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, Pushpvihar, New Delhi, Delhi, India.
30 July 2018
22 November 2018
30 November 2018
01 April 2019