THERAPEUTIC SIGNIFICANCE OF INDOLE SCAFFOLD IN MEDICINAL CHEMISTRY
AbstractDiscovery of New Chemical Entities (NCEs) is the result of a series of high throughput screening process after the successful design and synthesis scheme. The indole nucleus is an important heterocyclic compound containing nitrogen, and it has been a source of vital therapeutic agents. It is noteworthy in recent advances of synthetic, medicinal chemistry; the last decade has been witnessed with a multitude of reports on several indole derivatives corroborating these chemical entities to be an eminent target for the discovery of new drugs. Global research investigations published has outstanding impact attention for the scientists working on indole derivatives which transformed into various commercially approved indole candidate in the commercial market and there are several in the pipeline. This review highlighted recent achievements of indole lead molecules in biological, chemical, and pharmacological activity having diverse perspectives on how this indole moiety as a privileged structure may be browbeaten for elucidating salubrious biological activities.
Article Information
15
5441-5460
964
2184
English
IJPSR
K. Hussain, M. J. Alam, A. Hussain and N. A. Siddique *
Bioactive Natural Compound, Laboratory (BNCL), Department of Pharmacognosy and Phytochemistry, Glocal School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh, India.
siddique.nadeem567@gmail.com
11 February 2020
27 April 2020
08 May 2020
10.13040/IJPSR.0975-8232.11(11).5441-60
01 November 2020
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